Based on a comprehensive investigation of the employment status of architectural design graduates at a certain university,this paper analyzes the correctness of the talent development direction of architectural design...Based on a comprehensive investigation of the employment status of architectural design graduates at a certain university,this paper analyzes the correctness of the talent development direction of architectural design in hopes of pro-viding a valuable reference for further teaching reform and strengthening school-enterprise collaboration.The research re-sults show that architectural design is the main choice of graduates,accounting for as high as 63%,and traditional architec-tural design skills continue to be in demand in the market.Employment in fields such as interior design,BIM design,and green architecture is also included.The distribution of job positions for graduates is mainly in the areas of scheme design assistants and construction drawing design,requiring software operation,communication,scheme design,and construction drawing skills.This paper also proposes talent development measures such as optimizing the curriculum,strengthening faculty construction,and deepening school-enterprise collaboration,in order to improve the quality of talent development and the competitiveness of graduates.展开更多
Nitrate(NO_(3)^(-)) uptake involves a finely regulated and complex multilevel response system.Elucidating the molecular mechanism of nitrate uptake may lead to improving the growth and productivity of plants in the pr...Nitrate(NO_(3)^(-)) uptake involves a finely regulated and complex multilevel response system.Elucidating the molecular mechanism of nitrate uptake may lead to improving the growth and productivity of plants in the presence of dynamic variation in nitrate concentration.In this study,we identified three lateral organ boundaries domain(LBD)transcription factors,OsLBD37,OsLBD38,and OsLBD39,as regulators of nitrate uptake in response to nitrogen(N)availability.OsLBD37,OsLBD38,and OsLBD39 were induced by ammonium and glutamine in rice roots.Individual or collective knockout of OsLBD37,OsLBD38,and OsLBD39 led to increased concentrations of nitrate and increased expression of OsNRT2.1,OsNRT2.2,and OsNRT2.3respectively under high-N conditions,whereas overexpression of each of these three LBD genes produced opposite effects where N accumulation was reduced.Dual-luciferase reporter assay further confirmed that OsLBD37,OsLBD38,and OsLBD39 possessed transcription inhibitory activities in rice protoplast cells,downregulating the expression of OsNRT2.1/OsNRT2.2/OsNRT2.3.Yeast two-hybrid and bimolecular fluorescence complementation assays showed that OsLBD37 interacted with OsLBD37,OsLBD38,and OsLBD39in the nucleus.Together,these results show that OsLBD37,OsLBD38,and OsLBD39 collaborate to inhibit the expression of OsNRT2.1/OsNRT2.2/OsNRT2.3 transporters under N-sufficient conditions,thereby helping rice plants avoid excessive nitrate accumulation that may affect their growth.展开更多
Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological activities.To clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were desi...Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological activities.To clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were designed and synthesized by conjugation with 7-nitrobenzo-2-oxa-1,3-diazole(NBD)fluorophore.Among them,5c exhibited similar anti-proliferative activity with UA against HCT116 cells(half maximal inhibitory concentration(IC_(50))=9.21±0.50μmol/L).Cell imaging experiment indicated that 5c was rapidly taken up in HCT116 cells in a dose and time-dependent manner.Then,5c was found to localize in endoplasmic reticulum(ER),lysosomes,and mitochondria,but not in nucleus of HCT116 cells by confocal microscopy studies.Preliminary MOA proved that UA induced autophagy with a unique intracellular distribution mechanism involving ER and lysosome.In all,our work provides new clues for revealing the molecular mechanism of UA as an antitumor agent.展开更多
CuFe-SSZ-13 catalyst showed excellent performance in the selective catalytic reduction of NO_x with NH_3(NH_3-SCR) for diesel engine exhaust purification. To investigate the effect of preparation methods on NH_3-SCR p...CuFe-SSZ-13 catalyst showed excellent performance in the selective catalytic reduction of NO_x with NH_3(NH_3-SCR) for diesel engine exhaust purification. To investigate the effect of preparation methods on NH_3-SCR performance, Fe was loaded into one-pot synthesized Cu-SSZ-13 catalysts through solid-state ion-exchange(SSIE), homogeneous deposition precipitation(HDP) and liquid ion-exchange(IE), respectively. Three CuFe-SSZ-13 catalysts showed similar SO_2 resistance, which was better than that of Cu-SSZ-13. The improvement was attributed to the protection of Fe species. Hydrothermal stability of three CuFe-SSZ-13 catalysts was significantly different, which was attributed to the state of active species caused by different preparation methods. Compared with the other two catalysts, more active species existed inside the zeolite pores of CuFe-SSZ-13 SSIE. During hydrothermal aging, the aggregation of these active species in the pores caused the collapse of catalyst structure, ultimately leading to the deactivation of CuFe-SSZ-13 SSIE. In contrast, Fe species was dispersed better on the surface over CuFe-SSZ-13 IE, enhancing the hydrothermal stability of catalysts. Consequently, Fe loading effectively improved the resistance of SO_2 and H_2O over Cu-SSZ-13. For CuFe-SSZ-13, large amounts of active species located inside the zeolite pores are not beneficial for the hydrothermal stability.展开更多
Industrial policy is an important means for governments to promote industrial development and accelerate economic growth.This paper mainly uses the Chinese Law and Regulation Database as the source of the relevant law...Industrial policy is an important means for governments to promote industrial development and accelerate economic growth.This paper mainly uses the Chinese Law and Regulation Database as the source of the relevant laws and regulations of China’s industrial policies from 2003 to 2015.On this basis,it empirically examines the impact of industrial policies on economic growth.The study finds that China’s industrial policy has significant positive effects on economic growth and that industrial structure rationalization is an important channel of industrial policy to improve economic growth.The findings are also valid under a series of robustness tests and endogenous corrections.The results of heterogeneity tests confirm that there are heterogeneous effects pertaining to industrial policy on economic growth among different subregional areas,administrative levels,industrial development stages,and industrial policy types.Overall,this paper supports the hypothesis that industrial policy has positive effects on economic growth and,accordingly,provides a basis for industrial policy implementation.展开更多
The near infrared (NIR) spectroscopy technique has wide applications in agriculture with the advantages of being nondestructive, sensitive, safe and rapid. However, there are still more than 40 error sources influenci...The near infrared (NIR) spectroscopy technique has wide applications in agriculture with the advantages of being nondestructive, sensitive, safe and rapid. However, there are still more than 40 error sources influencing the robustness and accuracy of its calibration and operation. Environmental, sample and instrument factors that influence the analysis are discussed in this review, including temperature, humidity and other factors that introduce uncertainty. Error sources from livestock products, fruit and vegetables, which are the most common objects in the field of NIR analysis, are also emphasized in the second part. In addition, studies utilizing different instruments, spectral pretreatments, variable selection methods, wavelength ranges, detection modes and calibration methods are tabulated to illustrate the complications they introduce and how they influence NIR analysis. It is suggested that large scale of data with abundant varieties can be used to build a more robust calibration model, in order to improve the robustness and accuracy of the NIR analytical model, and overcome problems caused by confining analysis to too many uniform samples.展开更多
4-Amino-1,8-naphthalimide(ANI) represents a valuable fluorophore from which a large number of probes have been derived in order to meet the requirements from the fields of biological sensing and imaging. In this revie...4-Amino-1,8-naphthalimide(ANI) represents a valuable fluorophore from which a large number of probes have been derived in order to meet the requirements from the fields of biological sensing and imaging. In this review, the major progresses of ANI-based fluorescent probes in the past decade have been highlighted and categorized into three trends. The future development of ANI probes is also expected. This review provides a great deal of references and illuminating comments which will be helpful for the researchers designing and using fluorescent probes.展开更多
FeTiOx has been recognized as an environmental-friendly and cost-effective catalyst for selective catalytic reduction(SCR)of NOx with NH3.Aimed at further improving the low-temperature DeNOx efficiency of FeTiOx catal...FeTiOx has been recognized as an environmental-friendly and cost-effective catalyst for selective catalytic reduction(SCR)of NOx with NH3.Aimed at further improving the low-temperature DeNOx efficiency of FeTiOx catalyst,a simple strategy of CeO_(2) doping was proposed.The low-temperature(<250°C)NH3-SCR activity of FeTiOx catalyst could be dramatically enhanced by CeO2 doping,and the optimal composition of the catalyst was confirmed as FeCe_(0.2)TiOx,which performed a NOx conversion of 90%at ca.200°C.According to X-ray diffraction(XRD),Raman spectra and X-ray absorption fine structure spectroscopy(XAFS)analysis,FeCe_(0.2)TiOx showed low crystallinity,with Fe and Ce species well mixed with each other.Based on the fitting results of extended X-ray absorption fine structure(EXAFS),a unique Ce-O-Fe structure was formed in FeCe_(0.2)TiOx catalyst.The well improved specific surface area and the newly formed Ce-O-Fe structure dramatically contributed to the improvement of the redox property of FeCe_(0.2)TiOx catalyst,which was well confirmed by H2-temperature-programmed reduction(H2-TPR)and in situ XAFS experiments.Such enhanced redox capability could benefit the activation of NO and NH_(3) at low temperatures for NOx removal.The detailed reaction mechanism study further suggested that the facile oxidative dehydrogenation of NH_(3) to highly reactive-NH_(2) played a key role in enhancing the low-temperature NH_(3)-SCR performance of FeCe_(0.2)TiOx catalyst.展开更多
This paper employs a hybrid methodology that combines case study and econometric research to examine the impact of the Internet on domestic market integration. There is not much research on this issue in the literatur...This paper employs a hybrid methodology that combines case study and econometric research to examine the impact of the Internet on domestic market integration. There is not much research on this issue in the literature. From the multi-case analysis, this paper firstly obtains two main indications which are clear yet contrary to each other about how the Internet influences the market integration process. To be specific, although the Internet has both the ability and the potential to promote market integration, it is not always effective and could even harm this process due to several constraints. Using a provincial-level panel dataset from 2007 to 2013 in China, this paper empirically investigates whether the Internet plays a positive role in the market integration process. Contradictory to common expectations, we do not find any empirical evidence that the Intemet accelerates the integration of domestic markets. Thus, when compared with taking advantage of Internet tools, manmade obstacles to market integration that exist in current trading systems and business models deserve more attention.展开更多
Based on the theory of technology spillover in international trade, this paper discusses the technological innovation effect of trade by taking the influence of domestic trade into account. Under the constraint of the...Based on the theory of technology spillover in international trade, this paper discusses the technological innovation effect of trade by taking the influence of domestic trade into account. Under the constraint of the production possibility frontier, there is either complementarity or substitutability between domestic and foreign trade. It must be decided whether resources should be concentrated in one of the sectors (trade specialization) or instead allocated equally (trade equalization) between the two sectors. This paper firstly discusses how domestic trade and foreign trade work together to influence technological innovation, and how trade equalization and specialization affect different types of innovation. Using a provincial-level panel dataset from 2007 to 2015 in China, this paper constructs the indicators of domestic and foreign trade linkage and examines the impact of trade on innovation. The findings show that trade equalization mainly promotes incremental innovation, while trade specialization improves radical innovation. Thus, in the area of incremental innovation, attention should be paid to the equalized development of domestic and foreign trade, while in areas pursuing radical innovation, emphasis should be put on the specialization of the trade sector, avoiding equal allocation of resources to the two sectors.展开更多
To test the hypothesis that the microviscosity changes of Endoplasmic Reticulum(ER)can be a useful indicator of ferroptosis promoted by ER Stresses(ERS),a new ER targeting viscosity rotor,L-Vis-1 was developed and app...To test the hypothesis that the microviscosity changes of Endoplasmic Reticulum(ER)can be a useful indicator of ferroptosis promoted by ER Stresses(ERS),a new ER targeting viscosity rotor,L-Vis-1 was developed and applied in the quantitation of viscosity by FLIM imaging in live cells.The FLIM imag-ing exhibited an excellent resolution almost as good as the corresponding confocal imaging,more sig-nificantly,during ferroptosis processes promoted by different types of ERS,the viscosity increases were clearly monitored by FLIM of L-Vis-1 within ER,which has not been demonstrated before.展开更多
In the context of the information society,wearable devices show broad prospects in the fields of vital signs monitoring,plant health monitoring,artificial electronic skin.As an inseparable part of wearable devices,fle...In the context of the information society,wearable devices show broad prospects in the fields of vital signs monitoring,plant health monitoring,artificial electronic skin.As an inseparable part of wearable devices,flexible pressure/strain sensors have attracted wide attention.Structures and active materials are core factors affecting sensing performance.For the past few years,the introduction of carbon materials,especially carbon nanotubes,has provided more possibilities for improving performance.Great efforts have been devoted to researching pressure/strain sensors based on carbon nanotubes with excellent performance or unique features.Herein,the process in recent years in novel flexible pressure/strain sensors based on carbon nanotubes is reviewed.Fabrication strategies are discussed because it suggests sensing performance with significant differences and gives additional features like biodegradability and corrosion resistance to sensors.Furthermore,the scope of application has been extended to plant monitor,except for common human movement monitor.This review can help the researchers compare the influence of different fabrication strategies on the sensing performance and provide references for fabricating sensors in different applications.展开更多
基金Education Research and Reform Projects of Shenzhen Polytechnic University,China(Project No.7022310092)2022 Green Building Design Golden Course Construction Project of Shenzhen Polytechnic University,China+3 种基金2023 Guangdong Provincial Education and Teaching Reform Research and Practice Project,China2021 College Student Innovation Project of Shenzhen Polytechnic University,China(Project No.P-20210607-39632)2023 Education and Teaching Reform Project of the Higher Vocational Civil Engineering and Water Resources Instruction Committee of Guangdong Province,China(Project No.2023TJSL21)The Class II Brand Specialty Construction of the Guangdong Province,China(Project No.9004-02200202)。
文摘Based on a comprehensive investigation of the employment status of architectural design graduates at a certain university,this paper analyzes the correctness of the talent development direction of architectural design in hopes of pro-viding a valuable reference for further teaching reform and strengthening school-enterprise collaboration.The research re-sults show that architectural design is the main choice of graduates,accounting for as high as 63%,and traditional architec-tural design skills continue to be in demand in the market.Employment in fields such as interior design,BIM design,and green architecture is also included.The distribution of job positions for graduates is mainly in the areas of scheme design assistants and construction drawing design,requiring software operation,communication,scheme design,and construction drawing skills.This paper also proposes talent development measures such as optimizing the curriculum,strengthening faculty construction,and deepening school-enterprise collaboration,in order to improve the quality of talent development and the competitiveness of graduates.
基金supported by the National Natural Science Foundation of China(32171943 and 31821005)。
文摘Nitrate(NO_(3)^(-)) uptake involves a finely regulated and complex multilevel response system.Elucidating the molecular mechanism of nitrate uptake may lead to improving the growth and productivity of plants in the presence of dynamic variation in nitrate concentration.In this study,we identified three lateral organ boundaries domain(LBD)transcription factors,OsLBD37,OsLBD38,and OsLBD39,as regulators of nitrate uptake in response to nitrogen(N)availability.OsLBD37,OsLBD38,and OsLBD39 were induced by ammonium and glutamine in rice roots.Individual or collective knockout of OsLBD37,OsLBD38,and OsLBD39 led to increased concentrations of nitrate and increased expression of OsNRT2.1,OsNRT2.2,and OsNRT2.3respectively under high-N conditions,whereas overexpression of each of these three LBD genes produced opposite effects where N accumulation was reduced.Dual-luciferase reporter assay further confirmed that OsLBD37,OsLBD38,and OsLBD39 possessed transcription inhibitory activities in rice protoplast cells,downregulating the expression of OsNRT2.1/OsNRT2.2/OsNRT2.3.Yeast two-hybrid and bimolecular fluorescence complementation assays showed that OsLBD37 interacted with OsLBD37,OsLBD38,and OsLBD39in the nucleus.Together,these results show that OsLBD37,OsLBD38,and OsLBD39 collaborate to inhibit the expression of OsNRT2.1/OsNRT2.2/OsNRT2.3 transporters under N-sufficient conditions,thereby helping rice plants avoid excessive nitrate accumulation that may affect their growth.
基金supported in part by the National Key Research and Development Program of China(No.2022YFC3400501)the National Natural Science Foundation of China(Nos.81825020 and 82150208 to H.L.)+2 种基金the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project(Nos.21S11907900 and 20S11901000 to Z.Z.)sponsored by the National Program for Special Supports of Eminent Professionalsthe National Program for Support of Top-Notch Young Professionals.
文摘Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological activities.To clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were designed and synthesized by conjugation with 7-nitrobenzo-2-oxa-1,3-diazole(NBD)fluorophore.Among them,5c exhibited similar anti-proliferative activity with UA against HCT116 cells(half maximal inhibitory concentration(IC_(50))=9.21±0.50μmol/L).Cell imaging experiment indicated that 5c was rapidly taken up in HCT116 cells in a dose and time-dependent manner.Then,5c was found to localize in endoplasmic reticulum(ER),lysosomes,and mitochondria,but not in nucleus of HCT116 cells by confocal microscopy studies.Preliminary MOA proved that UA induced autophagy with a unique intracellular distribution mechanism involving ER and lysosome.In all,our work provides new clues for revealing the molecular mechanism of UA as an antitumor agent.
基金supported by the National Natural Science Foundation of China(No.51508231)
文摘CuFe-SSZ-13 catalyst showed excellent performance in the selective catalytic reduction of NO_x with NH_3(NH_3-SCR) for diesel engine exhaust purification. To investigate the effect of preparation methods on NH_3-SCR performance, Fe was loaded into one-pot synthesized Cu-SSZ-13 catalysts through solid-state ion-exchange(SSIE), homogeneous deposition precipitation(HDP) and liquid ion-exchange(IE), respectively. Three CuFe-SSZ-13 catalysts showed similar SO_2 resistance, which was better than that of Cu-SSZ-13. The improvement was attributed to the protection of Fe species. Hydrothermal stability of three CuFe-SSZ-13 catalysts was significantly different, which was attributed to the state of active species caused by different preparation methods. Compared with the other two catalysts, more active species existed inside the zeolite pores of CuFe-SSZ-13 SSIE. During hydrothermal aging, the aggregation of these active species in the pores caused the collapse of catalyst structure, ultimately leading to the deactivation of CuFe-SSZ-13 SSIE. In contrast, Fe species was dispersed better on the surface over CuFe-SSZ-13 IE, enhancing the hydrothermal stability of catalysts. Consequently, Fe loading effectively improved the resistance of SO_2 and H_2O over Cu-SSZ-13. For CuFe-SSZ-13, large amounts of active species located inside the zeolite pores are not beneficial for the hydrothermal stability.
文摘Industrial policy is an important means for governments to promote industrial development and accelerate economic growth.This paper mainly uses the Chinese Law and Regulation Database as the source of the relevant laws and regulations of China’s industrial policies from 2003 to 2015.On this basis,it empirically examines the impact of industrial policies on economic growth.The study finds that China’s industrial policy has significant positive effects on economic growth and that industrial structure rationalization is an important channel of industrial policy to improve economic growth.The findings are also valid under a series of robustness tests and endogenous corrections.The results of heterogeneity tests confirm that there are heterogeneous effects pertaining to industrial policy on economic growth among different subregional areas,administrative levels,industrial development stages,and industrial policy types.Overall,this paper supports the hypothesis that industrial policy has positive effects on economic growth and,accordingly,provides a basis for industrial policy implementation.
基金the financial support provided by the Science and Technology Cooperation Project between Hong Kong,Macao and Taiwan(2015DFT30150)
文摘The near infrared (NIR) spectroscopy technique has wide applications in agriculture with the advantages of being nondestructive, sensitive, safe and rapid. However, there are still more than 40 error sources influencing the robustness and accuracy of its calibration and operation. Environmental, sample and instrument factors that influence the analysis are discussed in this review, including temperature, humidity and other factors that introduce uncertainty. Error sources from livestock products, fruit and vegetables, which are the most common objects in the field of NIR analysis, are also emphasized in the second part. In addition, studies utilizing different instruments, spectral pretreatments, variable selection methods, wavelength ranges, detection modes and calibration methods are tabulated to illustrate the complications they introduce and how they influence NIR analysis. It is suggested that large scale of data with abundant varieties can be used to build a more robust calibration model, in order to improve the robustness and accuracy of the NIR analytical model, and overcome problems caused by confining analysis to too many uniform samples.
基金supported by the National Natural Science Foundation of China (Nos. 21421005, 21576040 and 21776037)
文摘4-Amino-1,8-naphthalimide(ANI) represents a valuable fluorophore from which a large number of probes have been derived in order to meet the requirements from the fields of biological sensing and imaging. In this review, the major progresses of ANI-based fluorescent probes in the past decade have been highlighted and categorized into three trends. The future development of ANI probes is also expected. This review provides a great deal of references and illuminating comments which will be helpful for the researchers designing and using fluorescent probes.
基金support from the Key Project of National Natural Science Foundation of China(No.21637005)Accelerator Research Organization(KEK)(Japan)for the generous help in XAS experiments conducted at Photon Factory,KEK,Japan(No.2012G537).
文摘FeTiOx has been recognized as an environmental-friendly and cost-effective catalyst for selective catalytic reduction(SCR)of NOx with NH3.Aimed at further improving the low-temperature DeNOx efficiency of FeTiOx catalyst,a simple strategy of CeO_(2) doping was proposed.The low-temperature(<250°C)NH3-SCR activity of FeTiOx catalyst could be dramatically enhanced by CeO2 doping,and the optimal composition of the catalyst was confirmed as FeCe_(0.2)TiOx,which performed a NOx conversion of 90%at ca.200°C.According to X-ray diffraction(XRD),Raman spectra and X-ray absorption fine structure spectroscopy(XAFS)analysis,FeCe_(0.2)TiOx showed low crystallinity,with Fe and Ce species well mixed with each other.Based on the fitting results of extended X-ray absorption fine structure(EXAFS),a unique Ce-O-Fe structure was formed in FeCe_(0.2)TiOx catalyst.The well improved specific surface area and the newly formed Ce-O-Fe structure dramatically contributed to the improvement of the redox property of FeCe_(0.2)TiOx catalyst,which was well confirmed by H2-temperature-programmed reduction(H2-TPR)and in situ XAFS experiments.Such enhanced redox capability could benefit the activation of NO and NH_(3) at low temperatures for NOx removal.The detailed reaction mechanism study further suggested that the facile oxidative dehydrogenation of NH_(3) to highly reactive-NH_(2) played a key role in enhancing the low-temperature NH_(3)-SCR performance of FeCe_(0.2)TiOx catalyst.
文摘This paper employs a hybrid methodology that combines case study and econometric research to examine the impact of the Internet on domestic market integration. There is not much research on this issue in the literature. From the multi-case analysis, this paper firstly obtains two main indications which are clear yet contrary to each other about how the Internet influences the market integration process. To be specific, although the Internet has both the ability and the potential to promote market integration, it is not always effective and could even harm this process due to several constraints. Using a provincial-level panel dataset from 2007 to 2013 in China, this paper empirically investigates whether the Internet plays a positive role in the market integration process. Contradictory to common expectations, we do not find any empirical evidence that the Intemet accelerates the integration of domestic markets. Thus, when compared with taking advantage of Internet tools, manmade obstacles to market integration that exist in current trading systems and business models deserve more attention.
文摘Based on the theory of technology spillover in international trade, this paper discusses the technological innovation effect of trade by taking the influence of domestic trade into account. Under the constraint of the production possibility frontier, there is either complementarity or substitutability between domestic and foreign trade. It must be decided whether resources should be concentrated in one of the sectors (trade specialization) or instead allocated equally (trade equalization) between the two sectors. This paper firstly discusses how domestic trade and foreign trade work together to influence technological innovation, and how trade equalization and specialization affect different types of innovation. Using a provincial-level panel dataset from 2007 to 2015 in China, this paper constructs the indicators of domestic and foreign trade linkage and examines the impact of trade on innovation. The findings show that trade equalization mainly promotes incremental innovation, while trade specialization improves radical innovation. Thus, in the area of incremental innovation, attention should be paid to the equalized development of domestic and foreign trade, while in areas pursuing radical innovation, emphasis should be put on the specialization of the trade sector, avoiding equal allocation of resources to the two sectors.
基金supported by the National Natural Science Foundation of China(Nos.21776037,22174009)Dalian Sci-ence and Technology Innovation Fund(No.2020JJ25CY014)Quanzhou Science and Technology Plan Project(No.2019C033R).
文摘To test the hypothesis that the microviscosity changes of Endoplasmic Reticulum(ER)can be a useful indicator of ferroptosis promoted by ER Stresses(ERS),a new ER targeting viscosity rotor,L-Vis-1 was developed and applied in the quantitation of viscosity by FLIM imaging in live cells.The FLIM imag-ing exhibited an excellent resolution almost as good as the corresponding confocal imaging,more sig-nificantly,during ferroptosis processes promoted by different types of ERS,the viscosity increases were clearly monitored by FLIM of L-Vis-1 within ER,which has not been demonstrated before.
基金This work was financially supported by the Joint Fund of the National Natural Science Foundation of China(Grant No.U20A2019).
文摘In the context of the information society,wearable devices show broad prospects in the fields of vital signs monitoring,plant health monitoring,artificial electronic skin.As an inseparable part of wearable devices,flexible pressure/strain sensors have attracted wide attention.Structures and active materials are core factors affecting sensing performance.For the past few years,the introduction of carbon materials,especially carbon nanotubes,has provided more possibilities for improving performance.Great efforts have been devoted to researching pressure/strain sensors based on carbon nanotubes with excellent performance or unique features.Herein,the process in recent years in novel flexible pressure/strain sensors based on carbon nanotubes is reviewed.Fabrication strategies are discussed because it suggests sensing performance with significant differences and gives additional features like biodegradability and corrosion resistance to sensors.Furthermore,the scope of application has been extended to plant monitor,except for common human movement monitor.This review can help the researchers compare the influence of different fabrication strategies on the sensing performance and provide references for fabricating sensors in different applications.