The ribosome is a cellular system responsible for translating the nucleotide code of mRNA into proteins.In human cells,this complex consists of four distinct ribosomal RNAs(rRNAs):The 28S,18S,5.8S,and 5S rRNAs,along w...The ribosome is a cellular system responsible for translating the nucleotide code of mRNA into proteins.In human cells,this complex consists of four distinct ribosomal RNAs(rRNAs):The 28S,18S,5.8S,and 5S rRNAs,along with 80 ribosomal proteins.Polymerase Ⅰ is responsible for synthesizing the 28S,18S,and 5.8S rRNAs,while polymerase Ⅲ is responsible for synthesizing the 5S rRNA[1].展开更多
RNA modifications are increasingly recognized for their significance in diverse physiological and pathological processes,with over 170 types of chemical modifications having been discovered since the1960s.Among these ...RNA modifications are increasingly recognized for their significance in diverse physiological and pathological processes,with over 170 types of chemical modifications having been discovered since the1960s.Among these modifications,N4-acetylcytidine(ac^(4)C)is the first acetylated modification identified on eukaryotic RNAs,previously reported in transfer RNA(t RNA)and ribosomal RNA(rRNA)。展开更多
OBJECTIVE: To assess the clinical curative effect of fuzi-cake-separated moxibustion at Zhongji(CV 3)and Guanyuan(CV 4) for preventing dysuria after internal fixation of lower limb fractures.METHODS: Sixty patients co...OBJECTIVE: To assess the clinical curative effect of fuzi-cake-separated moxibustion at Zhongji(CV 3)and Guanyuan(CV 4) for preventing dysuria after internal fixation of lower limb fractures.METHODS: Sixty patients conforming to the inclusion standards were randomly divided into a treatment group(n=30) and a control group(n=30).Fuzi-cake-separated moxibustion was performed at Guanyuan(CV 4) and Zhongji(CV 3), 20 min at a time, twice a day, for 3 days before operation in the treatment group. No fuzi-cake-separated moxibustion was performed in the control group. After treatment, the score for symptoms of first urination, urinary time, urinary volume, 24 h remaining urinary volume, incidence of uroschesis, and rate of controlling dysuria were compared to evaluate the curative effect of preventing post-operative dysuria.RESULTS: The score for symptoms of first urination,24 h remaining urinary volume(maximum 120 m L vs 250 m L, and less than 10 m L in 24 cases vs 15 cases), and the rate of controlling dysuria(83.34% vs30%) were significantly better(P<0.05, P<0.05, and P<0.001, respectively) in the treatment compared with the control group. There was no statistical difference(P>0.05) between the two groups in first post-operative urinary time, urinary volume, or incidence of 24 h uroschesis.CONCLUSION: Fuzi-cake-separated moxibustion at Zhongji(CV 3) and Guanyuan(CV 4) can better prevent post-operative dysuria, effectively promote the functional restoration of the urinary bladder,and control the incidence of post-operative dysuria.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC2601800)the Key-Area Research and Development Program of Guangdong Province(2023B1111020007)+6 种基金the National Natural Science Foundation of China(32161143017,82173833,81973343,and 82272658)the Guangdong Basic and Applied Basic Research Foundation(2023B1515040006)the Open Program of Shenzhen Bay Laboratory(SZBL202009051006)the Guangdong Provincial Key Laboratory of Construction Foundation(2023B1212060022)the Sichuan Science and Technology Program(2022JDRC0042 and 2022NSFSC0776)the Joint Research Foundation of Chengdu Medical College and the Seventh People’s Hospital(2022LHTD-02,2021LHJYPJ-08,and 2022488)the Shenzhen Bay Scholars Program。
文摘The ribosome is a cellular system responsible for translating the nucleotide code of mRNA into proteins.In human cells,this complex consists of four distinct ribosomal RNAs(rRNAs):The 28S,18S,5.8S,and 5S rRNAs,along with 80 ribosomal proteins.Polymerase Ⅰ is responsible for synthesizing the 28S,18S,and 5.8S rRNAs,while polymerase Ⅲ is responsible for synthesizing the 5S rRNA[1].
基金supported by the National Key Research and Development Program of China(2022YFC2601800)the National Natural Science Foundation of China(32161143017,82173833,82173126,82372743,81973343)+3 种基金the Guangdong Basic and Applied Basic Research Foundation(2023B1515040006,2022A1515011632)Science and Technology Planning Project of Guangdong Province,China(2022A0505050065)the Open Program of Shenzhen Bay Laboratory(SZBL202009051006)the Guangdong Provincial Key Laboratory of Construction Foundation(2023B1212060022)。
文摘RNA modifications are increasingly recognized for their significance in diverse physiological and pathological processes,with over 170 types of chemical modifications having been discovered since the1960s.Among these modifications,N4-acetylcytidine(ac^(4)C)is the first acetylated modification identified on eukaryotic RNAs,previously reported in transfer RNA(t RNA)and ribosomal RNA(rRNA)。
基金Supported by Shaoxing's Science and Technology Plan(No.2012D10020):Clinical research of fuzi-cake-separated moxibustion for preventing dysuria after operation for fracture
文摘OBJECTIVE: To assess the clinical curative effect of fuzi-cake-separated moxibustion at Zhongji(CV 3)and Guanyuan(CV 4) for preventing dysuria after internal fixation of lower limb fractures.METHODS: Sixty patients conforming to the inclusion standards were randomly divided into a treatment group(n=30) and a control group(n=30).Fuzi-cake-separated moxibustion was performed at Guanyuan(CV 4) and Zhongji(CV 3), 20 min at a time, twice a day, for 3 days before operation in the treatment group. No fuzi-cake-separated moxibustion was performed in the control group. After treatment, the score for symptoms of first urination, urinary time, urinary volume, 24 h remaining urinary volume, incidence of uroschesis, and rate of controlling dysuria were compared to evaluate the curative effect of preventing post-operative dysuria.RESULTS: The score for symptoms of first urination,24 h remaining urinary volume(maximum 120 m L vs 250 m L, and less than 10 m L in 24 cases vs 15 cases), and the rate of controlling dysuria(83.34% vs30%) were significantly better(P<0.05, P<0.05, and P<0.001, respectively) in the treatment compared with the control group. There was no statistical difference(P>0.05) between the two groups in first post-operative urinary time, urinary volume, or incidence of 24 h uroschesis.CONCLUSION: Fuzi-cake-separated moxibustion at Zhongji(CV 3) and Guanyuan(CV 4) can better prevent post-operative dysuria, effectively promote the functional restoration of the urinary bladder,and control the incidence of post-operative dysuria.
