Major depressive disorder (MDD) is the most common nonfatal disease burden world-wide. Systemic chronic low-grade inflammation has been reported to be associated with MDD pro-gression by affecting monoaminergic and gl...Major depressive disorder (MDD) is the most common nonfatal disease burden world-wide. Systemic chronic low-grade inflammation has been reported to be associated with MDD pro-gression by affecting monoaminergic and glutamatergic neurotransmission. However,whether various proinflammatory cytokines are abnormally elevated before the first episode of depression is still largely unclear. Here,we evaluated 184 adolescent patients who were experiencing their first episode of depressive disorder,and the same number of healthy individuals was included as con-trols. We tested the serum levels of high-sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-α(TNF-α),IgE,14 different types of food antigen-specific IgG,histamine,homocysteine,S100 calcium-binding protein B,and diamine oxidase. We were not able to find any significant dif-ferences in the serum levels of hs-CRP or TNF-αbetween the two groups. However,the histamine level of the patients (12.35μM) was significantly higher than that of the controls (9.73μM,P<0.001,Mann–Whitney U test). Moreover,significantly higher serum food antigen-specific IgG positive rates were also found in the patient group. Furthermore,over 80% of patients exhibited prolonged food intolerance with elevated levels of serum histamine,leading to hyperpermeability of the blood–brain barrier,which has previously been implicated in the pathogen-esis of MDD. Hence,prolonged high levels of serum histamine could be a risk factor for depressive disorders,and antihistamine release might represent a novel therapeutic strategy for depression treatment.展开更多
This study examines roll stability control for vehicles with an active roll-resistant electro-hydraulic suspension(RREHS)subsystem under steering maneuvers.First,we derive a vehicle model with four degrees of freedom ...This study examines roll stability control for vehicles with an active roll-resistant electro-hydraulic suspension(RREHS)subsystem under steering maneuvers.First,we derive a vehicle model with four degrees of freedom and incorporates yaw and roll motions.Second,an optimal linear quadratic regulator controller is obtained in consideration of dynamic vehicle performance.Third,an RREHS subsystem with an electric servo-valve actuator is proposed,and the corresponding dynamic equations are obtained.Fourth,field experiments are conducted to validate the performance of the vehicle model under sine-wave and double-lane-change steering maneuvers.Finally,the effectiveness of the active RREHS is determined by examining vehicle responses under sine-wave and double-lane-change maneuvers.The enhancement in vehicle roll stability through the RREHS subsystem is also verified.展开更多
基金supported by the Youth Psychological Development Base in China
文摘Major depressive disorder (MDD) is the most common nonfatal disease burden world-wide. Systemic chronic low-grade inflammation has been reported to be associated with MDD pro-gression by affecting monoaminergic and glutamatergic neurotransmission. However,whether various proinflammatory cytokines are abnormally elevated before the first episode of depression is still largely unclear. Here,we evaluated 184 adolescent patients who were experiencing their first episode of depressive disorder,and the same number of healthy individuals was included as con-trols. We tested the serum levels of high-sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-α(TNF-α),IgE,14 different types of food antigen-specific IgG,histamine,homocysteine,S100 calcium-binding protein B,and diamine oxidase. We were not able to find any significant dif-ferences in the serum levels of hs-CRP or TNF-αbetween the two groups. However,the histamine level of the patients (12.35μM) was significantly higher than that of the controls (9.73μM,P<0.001,Mann–Whitney U test). Moreover,significantly higher serum food antigen-specific IgG positive rates were also found in the patient group. Furthermore,over 80% of patients exhibited prolonged food intolerance with elevated levels of serum histamine,leading to hyperpermeability of the blood–brain barrier,which has previously been implicated in the pathogen-esis of MDD. Hence,prolonged high levels of serum histamine could be a risk factor for depressive disorders,and antihistamine release might represent a novel therapeutic strategy for depression treatment.
基金This work was supported by the National Natural Science Foundation of China(Grant No.5187051675)the Natural Science Foundation of Hunan Provincial(Grant No.2017JJ2031).
文摘This study examines roll stability control for vehicles with an active roll-resistant electro-hydraulic suspension(RREHS)subsystem under steering maneuvers.First,we derive a vehicle model with four degrees of freedom and incorporates yaw and roll motions.Second,an optimal linear quadratic regulator controller is obtained in consideration of dynamic vehicle performance.Third,an RREHS subsystem with an electric servo-valve actuator is proposed,and the corresponding dynamic equations are obtained.Fourth,field experiments are conducted to validate the performance of the vehicle model under sine-wave and double-lane-change steering maneuvers.Finally,the effectiveness of the active RREHS is determined by examining vehicle responses under sine-wave and double-lane-change maneuvers.The enhancement in vehicle roll stability through the RREHS subsystem is also verified.
