Klotho在肺癌中的研究进展

Klotho基因最早作为一种抗衰老基因被发现,其编码的Klotho蛋白在人类的多种组织中都有表达,该蛋白最显著的功能是调节磷酸盐稳态。Klotho蛋白有抑制相关信号通路、降低氧化应激并抑制炎症反应的作用,而这些过程与癌症发生密切相关。Klotho蛋白是多种恶性肿瘤的抑制因子,其表达与肿瘤的发生发展和患者预后都有关系。肺癌是最常见的恶性肿瘤之一,其发病率和死亡率在所有恶性肿瘤中位居前列。本文就Klotho与肺癌的发病机制、治疗预后关系的研究进展进行综述,对探索与肺癌的诊疗预后相关的新标志物和新靶点有重要意义。

Seasonal variation in the three-dimensional structures of coastal thermal front off western Guangdong

The seasonal structure and dynamic mechanism of oceanic surface thermal fronts(STFs)along the western Guangdong coast over the northern South China Sea shelf were analyzed using in situ observational data,remote sensing data,and numerical simulations.Both in situ and satellite observations show that the coastal thermal front exhibits substantial seasonal variability,being strongest in winter when it has the greatest extent and strongest sea surface temperature gradient.The winter coastal thermal front begins to appear in November and disappears after the following April.Although runoff water is more plentiful in summer,the front is weak in the western part of Guangdong.The frontal intensity has a significant positive correlation with the coastal wind speed,while the change of temperature gradient after September lags somewhat relative to the alongshore wind.The numerical simulation results accurately reflect the seasonal variation and annual cycle characteristics of the frontal structure in the simulated area.Based on vertical cross-section data,the different frontal lifecycles of the two sides of the Zhujiang(Pearl)River Estuary are analyzed.

Real-world validation of the chemotherapy-induced nausea and vomiting predictive model and its optimization for identifying high-risk Chinese patients

To the Editor:Chemotherapy-induced nausea and vomiting(CINV)is the most common and feared side effect reported by patients receiving chemotherapy.Despite significant progress,the incidence of CINV remains high.[1]Prevention is the key for controlling CINV.Evidence-based antiemetic guidelines recommend that strategies to prevent CINV should consider both the emetic risk of chemotherapeutic agents and patients’individual risk factors.[2]To date,several personal factors predicting a high risk of CINV have been identified,including expectancy of CINV.

One-step synthesis of Fe-Ni hydroxide nanosheets derived from bimetallic foam for efficient electrocatalytic oxygen evolution and overall water splitting

The research of superior water oxidation electrodes is essential for the green energy in the form of hydrogen by way of electrolytic water splitting, and still remains challenging. Based upon dealloying foam, Fe-Ni hydroxide nanosheets network structure is designed on the surface of Fe-Ni alloy foam. The ratio of Ni/Fe elements was adjusted to realize the optimal catalytic activities for oxygen evolution reaction（OER） and hydrogen evolution reaction（HER）. The obtained electrode of Fe-Ni hydroxide nanosheets/Fe-Ni alloy foam-60% Fe（FN LDH/FNF-60, 60 is the percentage of Fe content） possess low overpotential of 261 mV to reach 10 mA/cm;, small Tafel slope（85.5 mV/dec）, and superior long-term stability（remaining 10 mA/cm;for over 14 h without attenuation） toward OER in 1.0 mol/L KOH.Moreover, an alkaline water electrolyzer is constructed with the FN LDH/FNF-60 as anode and Ni（OH）;/Fe-Ni alloy foam-25% Fe(Ni（OH）;/FNF-25) as cathode, which displays superior electrolytic performance（affording 10 mA/cm;at 1.62 V） and lasting durability.

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

Netrin-1(NT-1)is one of the axon-guiding molecules that are critical for neuronal development.Because of its structural homology to the endothelial mitogens,NT-1 may have similar effects on vascular network formation.NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo.In the present study,we reported the delivery of NT-1 using an adeno-associated virus(AAV)vector(AAV-NT-1)into mouse brain followed by transient middle cerebral artery occlusion(tMCAO).We found that AAV vectors did not elicit a detectable inflammatory response,cell loss or neuronal damage after brain transduction.The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice.Furthermore,the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals(P<0.05)7 days after tMCAO.Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.

Ruthenium nanoclusters anchored on cobalt phosphide hollow microspheres by green phosphating process for full water splitting in acidic electrolyte

Transition metal phosphide(TMP) based electrocatalysts possessing special crystal and electronic structures attract broad attention in the field of electrocatalysis.Immense effort is made to optimize TMP catalysts aiming to satisfy the electrochemical catalysis performance.In this work,an environmentally friendly in situ green phosphating strategy and spatial limiting effect of the RuCo precursor is employed to fabricate the ruthenium nanoclusters anchored on cobalt phosphide hollow microspheres(Ru NCs/Co_(2)P HMs).The obtained Ru NCs/Co_(2)P HMs electrocatalysts exhibit high hydrogen evolution reaction(HER) activity at wide pH ranges,which require an overpotential of 77 mV to achieve the current density of 10 mA/cm^(2) in 0.5 mol/L H_(2)SO_(4) and 118 mV in 1.0 mol/L KOH.Besides,the multifunctional Ru NCs/Co_(2)P HMs exhibit good oxygen evolution reaction(OER) activity with an overpotential of 197 mV to reach the current density of 10 mA/cm^(2) in 0.5 mol/L H_(2)SO_(4),which is below that of the commercial RuO_(2) electrocatalyst(248 mV).A two-electrode electrolyzer is assembled as well,in acid electrolyte,it achieves a current density of 10 mA/cm^(2) at a voltage of 1.53 V,which is superior to that of the benchmark of precious metal-based electrolyzer(1.58 V).