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Trinity: Walking on a User-Object-Tag Heterogeneous Network for Personalised Recommendations 被引量:5
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作者 Ming-Xin Gan lily sun Rui Jiang 《Journal of Computer Science & Technology》 SCIE EI CSCD 2016年第3期577-594,共18页
The rapid evolution of the Internet has been appealing for effective recommender systems to pinpoint useful information from online resources. Although historical rating data has been widely used as the most important... The rapid evolution of the Internet has been appealing for effective recommender systems to pinpoint useful information from online resources. Although historical rating data has been widely used as the most important information in recommendation methods, recent advancements have been demonstrating the improvement in recommendation performance with the incorporation of tag information. Furthermore, the availability of tag annotations has been well addressed by such fruitful online social tagging applications as CiteULike, MovieLens and BibSonomy, which allow users to express their preferences, upload resources and assign their own tags. Nevertheless, most existing tag-aware recommendation approaches model relationships among users, objects and tags using a tripartite graph, and hence overlook relationships within the same types of nodes. To overcome this limitation, we propose a novel approach, Trinity, to integrate historical data and tag information towards personalised recommendation. Trinity constructs a three-layered object-user-tag network that considers not only interconnections between different types of nodes but also relationships within the same types of nodes. Based on this heterogeneous network, Trinity adopts a random walk with restart model to assign the strength of associations to candidate objects, thereby providing a means of prioritizing the objects for a query user. We validate our approach via a series of large-scale 10-fold cross-validation experiments and evaluate its performance using three comprehensive criteria. Results show that our method outperforms several existing methods, including supervised random walk with restart, simulation of resource allocating processes, and traditional collaborative filtering. 展开更多
关键词 recommender system tag-aware recommendation random walk with restart heterogeneous network socialtag
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血小板糖蛋白Ⅰbα因子突变(A156V)导致其与血管性血友病因子相互作用缺陷 被引量:2
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作者 董京飞 Chester Li +3 位作者 Alicia J.Schade lily sun Larry V.McIntire Jose A.Lopez 《中华血液学杂志》 CSCD 北大核心 2000年第9期453-456,共4页
目的 研究在流体切应力作用下表达突变的细胞与固着的血管性血友病因子 (vWF)相互作用中GPⅠbα突变 (A15 6V)的意义。方法 在GPⅠbαcDNA中直接诱发的突变克隆到哺乳类表达载体pDX的EcoRⅠ位点 ,随后将突变的cDNA转染在CHOβⅨ细胞... 目的 研究在流体切应力作用下表达突变的细胞与固着的血管性血友病因子 (vWF)相互作用中GPⅠbα突变 (A15 6V)的意义。方法 在GPⅠbαcDNA中直接诱发的突变克隆到哺乳类表达载体pDX的EcoRⅠ位点 ,随后将突变的cDNA转染在CHOβⅨ细胞。人的vWF通过甘氨酸和氯化钠沉淀及在Sepharose 4B柱分离的方法从血液冷沉淀制剂中纯化。纯化的vWF固着在盖玻片上 ,在平行板液流室中进行细胞滚动研究 ,用相差电视显微镜观察。结果 表达GPⅠb Ⅸ Ⅴ复合物的CHO细胞能粘附于并滚动在固着的vWF表面 ,当用表达A15 6V突变的细胞进行试验时 ,这些细胞虽然能粘附于并滚动在固着的vWF表面 ,但是它们滚动的速度明显快于其野生型 ,这表明突变的GPⅠbα与vWF之间的受体配体键的解离速度受损 ,单克隆抗体AN5 1与突变的GPⅠbα结合明显减少 ,表明A15 6V突变产生了GPⅠbα氨基端配体结合区的构象改变。结论 突变致使A15 6V突变细胞与固着的vWF产生较快的解离速度。突变的多肽在GPⅠbα氨基端配体结合区发生构象改变。 展开更多
关键词 血管性血友病因子 血小板糖蛋白Ⅰ 血友病 突变
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Mutation in the leucinerich repeat of platelet glycoprotein Ibαresults in defects in its interaction with immobilized von Willebrand factor under flow 被引量:1
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作者 董京飞 ChesterLi +4 位作者 Alicia J.Schade Becky J.Fredrickson lily sun Larry V.McIntire José A.López 《Chinese Medical Journal》 SCIE CAS CSCD 2000年第8期21-26,共6页
关键词 MUTATION GLYCOPROTEIN von Willebrand factor DEFECTS
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