期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
环状RNA在头颈部肿瘤侵袭转移中的研究进展 被引量:1
1
作者 吴丽媚 张焱 +2 位作者 何子蕊 聂诗情 陈文慧 《中国肿瘤临床》 CAS CSCD 北大核心 2020年第21期1119-1125,共7页
环状RNA(circRNA,circularRNA,环状核糖核酸)是非编码RNA中的一种,以反向剪接方式形成,具有种类多、丰度高、表达稳定、组织特异性强的特点。根据来源不同,环状RNA可分为来自编码基因即外显子序列、定位于细胞质的ecircRNA(exonic circR... 环状RNA(circRNA,circularRNA,环状核糖核酸)是非编码RNA中的一种,以反向剪接方式形成,具有种类多、丰度高、表达稳定、组织特异性强的特点。根据来源不同,环状RNA可分为来自编码基因即外显子序列、定位于细胞质的ecircRNA(exonic circRNA),仅含有内含子序列、主要定位于细胞核的ciRNA(circular intronic RNA)和同时具有外显子和内含子序列、主要定位于细胞核的ElciRNA(exon-intron circRNA)等3种类型。随着高通量测序和生物信息技术的发展,已发现环状RNA具有多种生物学功能,如作为竞争的内源性RNA或miRNA(microRNA,微核糖核酸)海绵、进行蛋白质翻译、与蛋白质结合相互作用、调节母本基因的选择性剪接或转录,从而参与多种疾病的生物过程,特别是肿瘤的发生发展以及肿瘤细胞的增殖、转移、凋亡等过程。作为全球第6大癌症,虽然目前头颈部肿瘤(head and neck cancer,HNC)的治疗方法较多,但其所处部位的特殊性给治疗带来困难,导致患者预后生存质量差。区域和(或)远处转移与HNC的死亡率有密切关系。本文综述了circRNA的生物发生、生物特征、生物功能及其目前在HNC的侵袭转移中的生物分子机制及生物学意义的研究进展,为继续探索HNC的转移致病机理提供参考。 展开更多
关键词 环状RNA 头颈部肿瘤侵袭转移
下载PDF
Analysis on Characteristics and Meteorological Influencing Factors of Air PM 2.5 Pollution in Chongqing,China
2
作者 Xianshuang YANG limei wu Chao JIN 《Meteorological and Environmental Research》 CAS 2020年第5期125-130,共6页
Based on the real-time data released by 17 atmospheric automatic stations in Chongqing,the pollution characteristics and variation trends of PM 2.5 and PM 10 and their correlations with meteorological factors from Jan... Based on the real-time data released by 17 atmospheric automatic stations in Chongqing,the pollution characteristics and variation trends of PM 2.5 and PM 10 and their correlations with meteorological factors from January 2014 to December 2018 were analyzed.The results show that the annual average mass concentration of PM 2.5 in Chongqing reduced from 65μg/m 3 in 2014 to 40μg/m 3 in 2018,and the annual average mass concentration of PM 10 decreased from 98μg/m 3 in 2014 to 64μg/m 3 in 2018.However,the annual average mass concentration of PM 2.5 in Chongqing from 2014 to 2018 and the annual average mass concentration of PM 10 from 2014 to 2016 exceeded the national level II standard,and the maximum exceeding standard rate was up to 0.86 and 0.40 times respectively.The monthly average mass concentration of PM 2.5 and PM 10 changed obviously,and the overall distribution was"U"-shaped.The ratio of PM 2.5 to PM 10 mass concentration ranged from 47.4%to 80.7%,with an average of 62.4%.The Pearson correlation coefficient between the mass concentration of PM 2.5 and PM 10 varied from 0.961 to 0.989,and there was a significant correlation at the confidence level of 0.01(bilateral).The mass concentration of PM 2.5 and PM 10 was extremely significantly correlated with average temperature,precipitation,and average air pressure,while there was no significant correlation between the mass concentrations of PM 2.5 and PM 10 and average relative humidity.The mass concentration of PM 2.5 and PM 10 was significantly correlated with sunshine duration. 展开更多
关键词 PM 2.5 PM 10 Meteorological factors CHONGQING
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部