In order to improve the comprehensive defense capability of data security in digital twins(DTs),an information security interaction architecture is proposed in this paper to solve the inadequacy of data protection and...In order to improve the comprehensive defense capability of data security in digital twins(DTs),an information security interaction architecture is proposed in this paper to solve the inadequacy of data protection and transmission mechanism at present.Firstly,based on the advanced encryption standard(AES)encryption,we use the keystore to expand the traditional key,and use the digital pointer to avoid the key transmission in a wireless channel.Secondly,the identity authentication technology is adopted to ensure the data integrity,and an automatic retransmission mechanism is added for the endogenous properties of the wireless channel.Finally,the software defined radio(SDR)platform composed of universal software radio peripheral(USRP)and GNU radio is used to simulate the data interaction between the physical entity and the virtual entity.The numerical results show that the DTs architecture can guarantee the encrypted data transmitted completely and decrypted accurately with high efficiency and reliability,thus providing a basis for intelligent and secure information interaction for DTs in the future.展开更多
Background:Amygdala plays an important role in the neurobiological basis of panic disorder(PD),and the amygdala contains different subregions,which may play different roles in PD.The aim of the present study was to ex...Background:Amygdala plays an important role in the neurobiological basis of panic disorder(PD),and the amygdala contains different subregions,which may play different roles in PD.The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the amygdala subregions in PD using resting-state functional magnetic resonance imaging and to explore the relationship between the abnormal spontaneous functional connectivity patterns of the regions of interest(ROIs)and the clinical symptoms of PD patients.Methods:Fifty-three drug-naïve,non-comorbid PD patients and 70 healthy controls(HCs)were recruited.Seed-based resting-state functional connectivity(rsFC)analyses were conducted using the bilateral amygdalae and its subregions as the ROI seed.Two samples t test was performed for the seed-based Fisher's z-transformed correlation maps.The relationship between the abnormal spontaneous functional connectivity patterns of the ROIs and the clinical symptoms of PD patients was investigated by Pearson correlation analysis.Results:PD patients showed increased rsFC of the bilateral amygdalae and almost all the amygdala subregions with the precuneus/posterior cingulate gyrus compared with the HC group(left amygdala[lAMY]:t=4.84,P<0.001;right amygdala[rAMY]:t=4.55,P<0.001;left centromedial amygdala[lCMA]:t=3.87,P<0.001;right centromedial amygdala[rCMA]:t=3.82,P=0.002;left laterobasal amygdala[lBLA]:t=4.33,P<0.001;right laterobasal amygdala[rBLA]:t=4.97,P<0.001;left superficial amygdala[lSFA]:t=3.26,P=0.006).The rsFC of the lBLA with the left angular gyrus/inferior parietal lobule remarkably increased in the PD group(t=3.70,P=0.003).And most of the altered rsFCs were located in the default mode network(DMN).A significant positive correlation was observed between the severity of anxiety and the rsFC between the lSFA and the left precuneus in PD patients(r=0.285,P=0.039).Conclusions:Our research suggested that the increased rsFC of amygdala subregions with DMN plays an important role in the pathogenesis of PD.Future studies may further explore whether the rsFC of amygdala subregions,especially with the regions in DMN,can be used as a biological marker of PD.展开更多
基金supported in part by the Intergovernmental International Cooperation in Science and Technology Innovation Program under Grants 2019YFE0111600in part by National Natural Science Foundation of China under Grants 62122069,62072490,62201507,and 62071431+2 种基金in part by Science and Technology Development Fund of Macao SAR under Grants 0060/2019/A1 and 0162/2019/A3in part by FDCT-MOST Joint Project under Grant 0066/2019/AMJin part by Research Grant of University of Macao under Grant MYRG2020-00107IOTSC。
文摘In order to improve the comprehensive defense capability of data security in digital twins(DTs),an information security interaction architecture is proposed in this paper to solve the inadequacy of data protection and transmission mechanism at present.Firstly,based on the advanced encryption standard(AES)encryption,we use the keystore to expand the traditional key,and use the digital pointer to avoid the key transmission in a wireless channel.Secondly,the identity authentication technology is adopted to ensure the data integrity,and an automatic retransmission mechanism is added for the endogenous properties of the wireless channel.Finally,the software defined radio(SDR)platform composed of universal software radio peripheral(USRP)and GNU radio is used to simulate the data interaction between the physical entity and the virtual entity.The numerical results show that the DTs architecture can guarantee the encrypted data transmitted completely and decrypted accurately with high efficiency and reliability,thus providing a basis for intelligent and secure information interaction for DTs in the future.
基金Capital’s Funds for Health Improvement and Research(No.2020-1-2121)Beijing Municipal Science and Technology Commission(No.Z181100001718077)Special Funding of the Beijing Municipal Administration of Hospitals Clinical Medicine Development(No.ZYLX201815)
文摘Background:Amygdala plays an important role in the neurobiological basis of panic disorder(PD),and the amygdala contains different subregions,which may play different roles in PD.The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the amygdala subregions in PD using resting-state functional magnetic resonance imaging and to explore the relationship between the abnormal spontaneous functional connectivity patterns of the regions of interest(ROIs)and the clinical symptoms of PD patients.Methods:Fifty-three drug-naïve,non-comorbid PD patients and 70 healthy controls(HCs)were recruited.Seed-based resting-state functional connectivity(rsFC)analyses were conducted using the bilateral amygdalae and its subregions as the ROI seed.Two samples t test was performed for the seed-based Fisher's z-transformed correlation maps.The relationship between the abnormal spontaneous functional connectivity patterns of the ROIs and the clinical symptoms of PD patients was investigated by Pearson correlation analysis.Results:PD patients showed increased rsFC of the bilateral amygdalae and almost all the amygdala subregions with the precuneus/posterior cingulate gyrus compared with the HC group(left amygdala[lAMY]:t=4.84,P<0.001;right amygdala[rAMY]:t=4.55,P<0.001;left centromedial amygdala[lCMA]:t=3.87,P<0.001;right centromedial amygdala[rCMA]:t=3.82,P=0.002;left laterobasal amygdala[lBLA]:t=4.33,P<0.001;right laterobasal amygdala[rBLA]:t=4.97,P<0.001;left superficial amygdala[lSFA]:t=3.26,P=0.006).The rsFC of the lBLA with the left angular gyrus/inferior parietal lobule remarkably increased in the PD group(t=3.70,P=0.003).And most of the altered rsFCs were located in the default mode network(DMN).A significant positive correlation was observed between the severity of anxiety and the rsFC between the lSFA and the left precuneus in PD patients(r=0.285,P=0.039).Conclusions:Our research suggested that the increased rsFC of amygdala subregions with DMN plays an important role in the pathogenesis of PD.Future studies may further explore whether the rsFC of amygdala subregions,especially with the regions in DMN,can be used as a biological marker of PD.