长期应用国产醋酸亮丙瑞林微球(单月剂型)治疗转移性前列腺癌时对血清睾酮的抑制和潜在刺激作用(英文)

Objective: We aimed to evaluate the efficiency of serum testosterone suppression as well as the potential for agonistic stimulation of serum testosterone during chronic treatment with monthly(3.75 mg) depot formulation of domestic substitute of leuprorelin acetate microspheres for patients with metastatic prostate cancer. Methods: A total of 23 patients with metastatic prostate cancer were enrolled in the prospective study and received 6 monthly intramuscular depot injections of domestic substitute of leuprorelin acetate microspheres. Their levels and patterns of serum testosterone suppression and the potential for agonistic stimulation of serum testosterone were monitored following injection monthly(3.75 mg) depot formulation of domestic substitute of leuprorelin acetate microspheres for 24 weeks. Results: Mean testosterone was 431.4 ng/dL, 119.3 ng/dL, 28.2 ng/dL by week 1, 2, 3 and decreased to less than 15.6 ng/dL by week 4 where it remained throughout the treatment period. Median time to suppression of serum testosterone was 20.7 days. No transient minor "escape" from suppression occurred in all patients which was defined as a single testosterone value greater than 50 ng/dL once suppression was achieved. Assessment of agonistic stimulation following the second depot injection revealed no pattern of stimulation. Conclusion: We concluded that monthly(3.75 mg) depot formulation of domestic substitute of leuprorelin acetate microspheres could provide persistent, stable suppression of serum testosterone throughout the dosing intervals, and that the initial depot injection of this formulation also could provide sufficient pituitary desensitization to prevent agnostic stimulation of serum testosterone during chronic treatment.

Mediating role of resilience in the relationship between COVID-19 related stigma and mental health among COVID-19 survivors:a cross-sectional study

Background The global coronavirus disease 2019(COVID-19)has caused many negative effects on physical and mental health of patients who have survived COVID-19.Apart from some long-lasting physical sequelae,those COVID-19 survivors are also suffering stigma and discrimination at different levels around the world.The current study aims to assess the role resilience played in stigma and mental disorders among COVID-19 survivors.Methods The cross-sectional study was carried out among former COVID-19 patients in Jianghan District(Wuhan,China)from June 10 to July 25,2021.The demographic questions,the Impact of Events Scale-Revised,the Generalized Anxiety Disorder Questionnaire,the Patient Health Questionnaire,the Resilience Style Questionnaire and the Short Version of COVID-19 Stigma Scale of 12 items were used to collect relevant information of the participants.Descriptive analyses,Pearson correlation analysis and Structural Equation Modeling were used to make data description and analysis.Results A total of 1541 out of 1601 COVID-19 survivors(887 females and 654 males)were included in the analysis.Perceived stigma of those COVID-19 survivors correlates significantly with anxiety(r=0.335,P<0.001),depression(r=0.325,P<0.001)and post-traumatic stress disorder(PTSD)(r=0.384,P<0.001).It has a direct effect on COVID-19 survivors’anxiety(β=0.326,P<0.001),depression(β=0.314,P<0.001),PTSD(β=0.385,P<0.001)and their resilience(β=−0.114,P<0.01).Resilience partially mediated the association between perceived stigma and anxiety(β=0.020,P<0.01),depression(β=0.020,P<0.01),and PTSD(β=0.014,P<0.01)among COVID-19 survivors.Conclusion Stigma has a significant negative impact on mental health,while resilience plays a mediator role in the relationship between stigma and mental health among COVID-19 survivors.Based on our study,we suggested that when designing psychological interventions for COVID-19 survivors,consideration should be taken into account to reduce stigma and improve resilience.

Characterization of phosphorus species and modeling for its organic forms in eutrophic shallow lake sediments, North China

Variations of phosphorus （P） and its species in surface sediment of Baiyangdian Lake, a eutrophic shallow lake located in North China, were investigated through combination of field survey and numerical calculation based on cluster analysis. P fractionation was performed by a sequential extraction scheme, categorized as loosely bound P （NH4Cl-P）, reductant soluble P （BD-P）, metallic oxide bound P （NaOH-P）, calcium bound P （HCl-P） and organic P （Org-P）. P concentrations exhibited regional similarities and a total of four sub-areas were identified in which the same rank was HCl-P 〉 Org-P 〉 BD-P ,=NaOH-P 〉NH4Cl-E NH4Cl-P, BD-P and Org-P were found to contribute to P enrichment in overlying water column. Specifically, labile Org-P acted as a potential pool with a greater contribution in aerobic layer compared to anaerobic layer. A hysteresis （lag = 4 months） existed when labile Org-P concentration was negatively correlated with aerobic layer thickness. In view of magnitude of identified P contributors in sub-areas, higher potential of P release was present in Fuhe River and Tang River estuary areas. On the basis of calibration and verification, the mathematical model with parameter settings applied in this study was improved to serve as a tool for limnology management and eutrophic control.

A Hierarchical Conical Array with Controlled Adhesion and Drop Bounce Ability for Reducing Residual Non-Newtonian Liquids

As a result of frequent food waste and environmental pollution,there has been an increasing demand for the development of packaging materials that intrinsically inhibit and reduce likelihood of non-Newtonian liquids adherence.In this work,inspired from ciliary structures on the leg of water strider,the hierarchical conical array was formed by magnetic field control and laser etching without any mask.Due to the tapered geometry of the cones and the multiscale surface roughness of the array,the droplets would bounce many times after impacting with the superhydrophobic surface(SHS)and roll off.By changing the spaces and apex angles of conical microcolumns the SHS has controlled adhesion,superior self-cleaning property and droplets bounce performance for a variety of non-Newtonian viscous liquids.After suffering from various types of damage including repeated tape tearing,finger touch and folding test,the SHS still maintained excellent superhydrophobic property,which may have potential application as all kinds of packaging interface materials.We demonstrate that the excellent droplets bounce behavior of the hierarchical array enables the efficient and robust prevention of food liquids adhesion.