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Stability of high-salinity-enhanced foam:Surface behavior and thin-film drainage 被引量:1
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作者 lin sun Xue-Hui sun +6 位作者 Yong-Chang Zhang Jun Xin Hong-Ying sun Yi-Bo Li Wan-Fen Pu Jin-Yu Tang Bing Wei 《Petroleum Science》 SCIE EI CAS CSCD 2023年第4期2343-2353,共11页
Cocamidopropyl hydroxyl sulfobetaine(CHSB)is one of the most promising foaming agents for high-salinity reservoirs because the salt in place facilitates its foam stability,even with salinity as high as 2×10^(5)mg... Cocamidopropyl hydroxyl sulfobetaine(CHSB)is one of the most promising foaming agents for high-salinity reservoirs because the salt in place facilitates its foam stability,even with salinity as high as 2×10^(5)mg/L.However,the synergistic effects between CHSB and salt have not been fully understood.This study utilized bulk foam tests and thin-film interferometry to comprehensively investigate the macroscopic and microscopic decay processes of CHSB foams with NaCl concentrations ranging from 2.3×10^(4)to 2.1×10^(5)mg/L.We focused on the dilatational viscoelasticity and dynamic thin-film thickness to elucidate the high-salinity-enhanced foam stability.The increase in dilatational viscoelasticity and supramolecular oscillating structural force(Π_(OS))with salinity dominated the superior stability of CHSB foam.With increasing salinity,more CHSB molecules accumulated on the surface with a lower diffusion rate,leading to high dilatational moduli and surface elasticity,thus decelerating coarsening and coalescence.Meanwhile,the number density of micelles in the thin film increased with salinity,resulting in increasedΠOS.Consequently,the energy barrier for stepwise thinning intensified,and the thin-film drainage slowed.This work conduces to understand the mechanisms behind the pronounced stability of betaine foam and can promote the widespread application of foam in harsh reservoirs. 展开更多
关键词 High-salinity reservoirs Betaine foam Foam stability Dilatational viscoelasticity Disjoining pressure Thin-film interferometry
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国家自然科学基金面上项目的遴选标准及其规范化探讨
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作者 江虎军 王蕊 +1 位作者 孙琳 高霏 《中国科学基金》 CSCD 北大核心 2024年第4期719-726,共8页
同行评议的决策机制中,获取同行专家提供的评议意见很重要,管理者如何基于评议意见做出科学决策也同样不可忽视。国家自然科学基金项目管理者面对大量的项目,且每个项目包含有多个同行专家的评议意见,如何汇总项目的评议意见并从众多项... 同行评议的决策机制中,获取同行专家提供的评议意见很重要,管理者如何基于评议意见做出科学决策也同样不可忽视。国家自然科学基金项目管理者面对大量的项目,且每个项目包含有多个同行专家的评议意见,如何汇总项目的评议意见并从众多项目中优中选优开展项目遴选,倘若没有科学且可把握的遴选标准,遴选过程的不规范、不科学必然事实上将对获取的同行专家评议意见打折扣。因此,建立科学、规范的项目遴选标准,减少遴选过程中可能存在的随意性,避免其中人为因素干扰,是确保同行评议制度公正性的重要环节。 展开更多
关键词 同行评议 基金项目 遴选标准
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A Scheme Library-Based Ant Colony Optimization with 2-Opt Local Search for Dynamic Traveling Salesman Problem
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作者 Chuan Wang Ruoyu Zhu +4 位作者 Yi Jiang Weili Liu Sang-Woon Jeon lin sun Hua Wang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第5期1209-1228,共20页
The dynamic traveling salesman problem(DTSP)is significant in logistics distribution in real-world applications in smart cities,but it is uncertain and difficult to solve.This paper proposes a scheme library-based ant... The dynamic traveling salesman problem(DTSP)is significant in logistics distribution in real-world applications in smart cities,but it is uncertain and difficult to solve.This paper proposes a scheme library-based ant colony optimization(ACO)with a two-optimization(2-opt)strategy to solve the DTSP efficiently.The work is novel and contributes to three aspects:problemmodel,optimization framework,and algorithmdesign.Firstly,in the problem model,traditional DTSP models often consider the change of travel distance between two nodes over time,while this paper focuses on a special DTSP model in that the node locations change dynamically over time.Secondly,in the optimization framework,the ACO algorithm is carried out in an offline optimization and online application framework to efficiently reuse the historical information to help fast respond to the dynamic environment.The framework of offline optimization and online application is proposed due to the fact that the environmental change inDTSPis caused by the change of node location,and therefore the newenvironment is somehowsimilar to certain previous environments.This way,in the offline optimization,the solutions for possible environmental changes are optimized in advance,and are stored in a mode scheme library.In the online application,when an environmental change is detected,the candidate solutions stored in the mode scheme library are reused via ACO to improve search efficiency and reduce computational complexity.Thirdly,in the algorithm design,the ACO cooperates with the 2-opt strategy to enhance search efficiency.To evaluate the performance of ACO with 2-opt,we design two challenging DTSP cases with up to 200 and 1379 nodes and compare them with other ACO and genetic algorithms.The experimental results show that ACO with 2-opt can solve the DTSPs effectively. 展开更多
关键词 Dynamic traveling salesman problem(DTSP) offline optimization and online application ant colony optimization(ACO) two-optimization(2-opt)strategy
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Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases 被引量:3
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作者 Tingting Han Yuxiang Xu +2 位作者 lin sun Makoto Hashimoto Jianshe Wei 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1241-1248,共8页
Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging;they have a great impact on the aging process and are the main risk factors for neurodegeneration.Review... Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging;they have a great impact on the aging process and are the main risk factors for neurodegeneration.Reviewing the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative diseases.This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases,including Alzheimer's disease,Huntington's chorea,and Parkinson's disease.This review also describes the potential benefits of treating neurodegenerative diseases by modulating changes in microglial states.Therefore,inducing a shift from the neurotoxic to neuroprotective microglial state in neurodegenerative diseases induced by aging and chronic inflammation holds promise for the treatment of neurodegenerative diseases in the future. 展开更多
关键词 AGING Alzheimer's disease cytokines Huntington's disease MICROGLIA neurodegenerative diseases NEUROINFLAMMATION NEUROPROTECTION NEUROTOXICITY Parkinson's disease
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白花泡桐叶片提取物的抗皮肤光老化作用研究
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作者 孙琳 张曼 《日用化学工业(中英文)》 CAS 北大核心 2024年第9期1092-1098,共7页
考察白花泡桐叶片提取物(Paulownia fortunei leaf extract,PFLE)对紫外线B(UVB)诱导的皮肤光老化小鼠的影响。将小鼠分为5组:分别为正常对照组(NC)、模型组(M)、低剂量PFLE组(L-PFLE)、中剂量PFLE组(M-PFLE)、高剂量PFLE组(H-PFLE)。N... 考察白花泡桐叶片提取物(Paulownia fortunei leaf extract,PFLE)对紫外线B(UVB)诱导的皮肤光老化小鼠的影响。将小鼠分为5组:分别为正常对照组(NC)、模型组(M)、低剂量PFLE组(L-PFLE)、中剂量PFLE组(M-PFLE)、高剂量PFLE组(H-PFLE)。NC组小鼠不照射。其他组小鼠使用紫外线光疗仪进行UVB照射。UVB照射当天,NC组和M组小鼠背部涂抹雪花膏,L-PFLE组、M-PFLE组和H-PFLE组小鼠分别涂抹50,100和200 mg/kg的PFLE乳膏。UVB照射和给药周期均为6周。检测了小鼠的体重、皮肤含水量、皮肤氧化应激指标、HYP和HA水平。采用HE染色观察小鼠皮肤形态。通过Western blotting检测了小鼠皮肤中Nrf2(细胞核)、Keap1和HO-1的蛋白表达水平。通过RT-qPCR检测了小鼠皮肤中MMP-1、MMP-3的转录水平。结果显示,与M组比较,L-PFLE组、M-PFLE组和H-PFLE组小鼠皮肤含水量升高,皮肤形态明显改善,SOD、CAT和GSH-Px水平升高,MDA水平降低,Nrf2(细胞核)和HO-1蛋白相对表达量升高,Keap1蛋白相对表达量降低,HYP和HA水平升高,MMP-1和MMP-3 mRNA相对表达量降低(P<0.05)。表明PELE经皮给药具有良好的抗皮肤光老化作用。 展开更多
关键词 白花泡桐叶片提取物 皮肤光老化 抗氧化 羟脯氨酸 透明质酸
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Yuzaoea gen. nov., a new biraphid diatom(Bacillariophyceae)genus and its phylogenetic significance
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作者 Honghan Liu Chenhong Li +6 位作者 Lang Li Xuesong Li lin sun Junrong Liang Jun Zhang Yahui Gao Changping Chen 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第2期130-136,共7页
The flexed frustules in pennate diatoms are usually associated with monoraphid diatoms. Interestingly, we found a biraphid diatom species with flexed frustules in an offshore intertidal beach environment on Weizhou Is... The flexed frustules in pennate diatoms are usually associated with monoraphid diatoms. Interestingly, we found a biraphid diatom species with flexed frustules in an offshore intertidal beach environment on Weizhou Island,Beihai City, Guangxi Zhuang Autonomous Region, China. Therefore, based on morphological characteristics, we described a new genus of diatoms Yuzaoea sinensis gen. et sp. nov. CH Li, HH Liu, YH Gao & CP Chen. The frustule of this genus is characterized by heterogeneous frustule with one concave valve and one convex valve,complete raphe on both valves, straight and moderately eccentric raphe, uniseriate striae and girdle bands with a single row of areolae. The most identifying feature of this genus was the flexed frustule, which is rare in biraphid diatoms and common in monoraphid diatoms. We compared the morphometric characteristics of genus Yuzaoea with genus Rhoikoneis and several genera within the family Rhoicospheniaceae, including Rhoicosphenia,Campylopyxis, and Cuneolus. Phylogenetic analyses based on SSU rRNA and rbc L showed that the genus Yuzaoea was the sister group to the clade of Rhoicosphenia with a high support value(bootstrap values = 100%), and the clade “Yuzaoea+Rhoicosphenia” was sister to the clade of monoraphid diatoms, in which the genera Achnanthidium, Planothidium and some Cocconeis with high support values(bootstrap = 100%).Morphologically, the genus Yuzaoea shares many morphological features with monoraphid diatoms like genera Achnanthidium and Planothidium and the members within the Rhoicospheniaceae. Therefore, based on a combined morphological studies and phylogenetic results we suggested that this branch may represented the evolution of one kind monoraphid diatoms, from biraphid diatoms(e.g. genus Yuzaoea), to incompleted biraphid diatoms(e.g. genera Rhoicosphenia, Campylopyxis), to monoraphid diatoms(e.g. genera Achnanthidium and Planothidium). 展开更多
关键词 biraphid diatom marine new genus Rhoicospheniaceae TAXONOMY Yuzaoea
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极低与低危险度胃肠间质瘤的病理及预后分析
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作者 刘莎莎 孙琳 +4 位作者 李佳鑫 赵帅 刘慧敏 梁寒 孙燕 《中国肿瘤临床》 CAS CSCD 北大核心 2024年第11期541-546,共6页
目的分析极低、低危险度胃肠间质瘤(gastrointestinal stromal tumors,GISTs)患者的预后情况及临床病理特征和基因突变特点。方法回顾性收集2011年1月至2020年12月于天津医科大学肿瘤医院经手术或内镜切除并经病理确诊的433例极低、低危... 目的分析极低、低危险度胃肠间质瘤(gastrointestinal stromal tumors,GISTs)患者的预后情况及临床病理特征和基因突变特点。方法回顾性收集2011年1月至2020年12月于天津医科大学肿瘤医院经手术或内镜切除并经病理确诊的433例极低、低危GIST,进行病理和预后分析。结果与低危GIST相比,极低危GIST中胃部GIST、Ki-67指数≤3%、核分裂象0~1个/5 mm2的患者所占比例较高,而小肠GIST所占比例较低(均P<0.05)。118例进行了基因检测,极低危GIST与低危GIST的突变类型及KIT突变类型比较无显著性差异(均P>0.05)。对无其他伴发疾病的87例极低危和210例低危GIST病例进行随访,中位随访时间为86(27~158)个月。全部极低危GIST患者均未发现进展;3例低危GIST发现复发/转移,无进展生存期(progression-free survival,PFS)为27~84个月。此3例原发肿瘤的核分裂象均为4个/5 mm2,接近低与中危险度GIST核分裂象的临界值,均检测到KIT exon11突变;首次进展后经伊马替尼治疗,在随访结束时均生存,总生存期(overall survival,OS)为116~155个月。结论在低危险度GIST患者中,极少数核分裂象偏高的患者存在复发/转移的可能性,但复发/转移后通过靶向治疗、手术等治疗手段,仍可维持长时间、高质量的生存。极低危GIST患者术后进展的可能性极小,可适当延长随访间隔时间,以减少医疗成本、减轻患者和家属的心理负担。 展开更多
关键词 胃肠间质瘤 极低危险度 低危险度 预后 监测
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Research on motor rotation anomaly detection based on improved VMD algorithm
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作者 Fuzhao Chen Zhilei Chen +4 位作者 Qian Chen Tianyang Gao Mingyan Dai Xiang Zhang lin sun 《Railway Sciences》 2024年第1期18-31,共14页
Purpose–The electromechanical brake system is leading the latest development trend in railway braking technology.The tolerance stack-up generated during the assembly and production process catalyzes the slight geomet... Purpose–The electromechanical brake system is leading the latest development trend in railway braking technology.The tolerance stack-up generated during the assembly and production process catalyzes the slight geometric dimensioning and tolerancing between the motor stator and rotor inside the electromechanical cylinder.The tolerance leads to imprecise brake control,so it is necessary to diagnose the fault of the motor in the fully assembled electromechanical brake system.This paper aims to present improved variational mode decomposition(VMD)algorithm,which endeavors to elucidate and push the boundaries of mechanical synchronicity problems within the realm of the electromechanical brake system.Design/methodology/approach–The VMD algorithm plays a pivotal role in the preliminary phase,employing mode decomposition techniques to decompose the motor speed signals.Afterward,the error energy algorithm precision is utilized to extract abnormal features,leveraging the practical intrinsic mode functions,eliminating extraneous noise and enhancing the signal’s fidelity.This refined signal then becomes the basis for fault analysis.In the analytical step,the cepstrum is employed to calculate the formant and envelope of the reconstructed signal.By scrutinizing the formant and envelope,the fault point within the electromechanical brake system is precisely identified,contributing to a sophisticated and accurate fault diagnosis.Findings–This paper innovatively uses the VMD algorithm for the modal decomposition of electromechanical brake(EMB)motor speed signals and combines it with the error energy algorithm to achieve abnormal feature extraction.The signal is reconstructed according to the effective intrinsic mode functions(IMFS)component of removing noise,and the formant and envelope are calculated by cepstrum to locate the fault point.Experiments show that the empirical mode decomposition(EMD)algorithm can effectively decompose the original speed signal.After feature extraction,signal enhancement and fault identification,the motor mechanical fault point can be accurately located.This fault diagnosis method is an effective fault diagnosis algorithm suitable for EMB systems.Originality/value–By using this improved VMD algorithm,the electromechanical brake system can precisely identify the rotational anomaly of the motor.This method can offer an online diagnosis analysis function during operation and contribute to an automated factory inspection strategy while parts are assembled.Compared with the conventional motor diagnosis method,this improved VMD algorithm can eliminate the need for additional acceleration sensors and save hardware costs.Moreover,the accumulation of online detection functions helps improve the reliability of train electromechanical braking systems. 展开更多
关键词 Electromechanical brake system Railway brake system Motor fault diagnosis Variational mode decomposition Error energy Feature extraction
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Wheel Setting Error Modeling and Compensation for Arc Envelope Grinding of Large-Aperture Aspherical Optics 被引量:2
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作者 Changsheng Li lin sun +4 位作者 Zhaoxiang Chen Jianfang Chen Qijing lin Jianjun Ding Zhuangde Jiang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2022年第5期87-99,共13页
Precision grinding is a key process for realizing the use of large-aperture aspherical optical elements in laser nuclear fusion devices,large-aperture astronomical telescopes,and high-resolution space cameras.In this ... Precision grinding is a key process for realizing the use of large-aperture aspherical optical elements in laser nuclear fusion devices,large-aperture astronomical telescopes,and high-resolution space cameras.In this study,the arc envelope grinding process of large-aperture aspherical optics is investigated using a CM1500 precision grinding machine with a maximum machinable diameter ofΦ1500 mm.The form error of the aspherical workpiece induced by wheel setting errors is analytically modeled for both parallel and cross grinding.Results show that the form error is more sensitive to the wheel setting error along the feed direction than that along the lateral direction.It is a bilinear function of the feed-direction wheel setting error and the distance to the optical axis.Based on the error function above,a method to determine the wheel setting error is proposed.Subsequently,grinding tests are performed with the wheels aligned accurately.Using a newly proposed partial error compensation method with an appropriate compensation factor,a form error of 3.4μm peak-to-valley(PV)for aΦ400 mm elliptical K9 glass surface is achieved. 展开更多
关键词 Aspherical optics Wheel setting Arc envelope grinding Form error Large aperture
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Blends of hydrophobic and swelling agents in the swelling layer in the preparation of delayed-release pellets of a hydrophilic drug with low MW: Physicochemical characterizations and in-vivo evaluations 被引量:2
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作者 Chang You Xuedan Liang +4 位作者 Jiabei sun lin sun Yitao Wang Tianyuan Fan Ying Zheng 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2014年第4期199-207,共9页
In this study,a hydrophobic material,ethylcellulose,which was used as its aqueous suspension Surelease^(®),was combined with a swelling agent as the swelling layer to prepare delayed-release pellets for Danshensu... In this study,a hydrophobic material,ethylcellulose,which was used as its aqueous suspension Surelease^(®),was combined with a swelling agent as the swelling layer to prepare delayed-release pellets for Danshensu,which is a hydrophilic drug with low MW.A rupturable,delayed-release pellet consists of a drug core,a swelling layer containing a swelling agent(cross-linked sodium carboxymethyl cellulose)with a hydrophobic agent(Surelease^(®)),and a controlled layer composed by an insoluble,water-permeable polymeric coating(aqueous ethylcellulose dispersions)was developed in a fluidised bed.Results showed that blending Surelease^(®)into the swelling layer could effectively extend the release of Danshensu from the pellets,which may be attributed to the slowed swelling rate by reduction of water penetration and improvement of mechanical integrity of the swelling layer.Drug in the delayed pellets showed sustained release in beagle dogs after oral administration with comparable in-vivo exposure to the uncoated drug pellets.In conclusion,blends of hydrophobic and swelling agents in the swelling layer in doublemembrane pellets could achieve a delayed drug-release profile in vitro,as well as delayed and sustained absorption in vivo for highly soluble,low-MW drug.The present study highlighted the potential use of a delayed-release system for other hydrophilic,low-MW drugs to meet the formulation requirements for chronopharmacological diseases. 展开更多
关键词 DANSHENSU Delayed-release pellets Swelling agent Surelease^(®) Cross-linked sodium carboxymethyl cellulose(CCeNa) Fluidised bed
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Removal of Metallic Impurities from Off-Grade Copper Concentrate in Alkaline Solution 被引量:1
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作者 Zhi-xiong Liu lin sun +4 位作者 Liang-dong Tang Jie Hu Yang Xiao Yi-guang Chen Zhou-lan Yin 《International Journal of Nonferrous Metallurgy》 2018年第2期9-23,共15页
The removal of metallic impurities from off-grade copper concentrate was investigated in alkaline solution with H2O2. The analysis results of XRD and SEM-EDS revealed the oxidative mechanisms of all sulfides. The infl... The removal of metallic impurities from off-grade copper concentrate was investigated in alkaline solution with H2O2. The analysis results of XRD and SEM-EDS revealed the oxidative mechanisms of all sulfides. The influence of various parameters of alkaline leaching were investigated including concentrations of sodium hydroxide and hydrogen peroxide, liquid to solid ratio, leaching time and temperature. The results showed that the removal rate of Mo, As and Zn were increased with increasing leaching time and H2O2 concentration, and that the removal rate of Mo, As and Zn were firstly increased and then slightly decreased with increasing liquid to solid ratio, temperature and NaOH concentration, respectively. More than 95% Mo, 94% As, and 94 % Zn are removed from the off-grade concentrate under the optimum conditions, while only 1.7% Cu is dissolved. These optimum conditions were sodium hydroxide 1.5 mol/L, hydrogen peroxide 1.0 mol/L, temperature 50&deg;C, liquid to solid ratio 5/1 mL/g and leaching time 5 h. 展开更多
关键词 Copper CONCENTRATE IMPURITIES REMOVAL ALKALINE LEACHING Hydrogen PEROXIDE
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催化光度法测定伊文思蓝褪色反应速率常数——推荐一个物理化学新实验
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作者 徐俊晖 戢凌俊 +3 位作者 孙琳 杨玉蓉 钟敏 王亚珍 《大学化学》 CAS 2023年第10期266-273,共8页
介绍了一个关于复杂反应动力学测量的物理化学实验。基于亚硝酸钠作用下溴酸钾氧化伊文思蓝褪色反应,通过测量不同初始反应条件下系统吸光度随时间的变化情况,推导伊文思蓝和溴酸钾的分级数,探讨亚硝酸钠对反应的加速作用,并根据不同温... 介绍了一个关于复杂反应动力学测量的物理化学实验。基于亚硝酸钠作用下溴酸钾氧化伊文思蓝褪色反应,通过测量不同初始反应条件下系统吸光度随时间的变化情况,推导伊文思蓝和溴酸钾的分级数,探讨亚硝酸钠对反应的加速作用,并根据不同温度下的测量数据计算表观反应活化能。本实验可依据学时安排开设为基础性实验或综合设计性实验。两个学期的教学实践表明,作为综合设计性实验,本实验可加强学生对表观速率常数、表观活化能以及催化作用的认识,并促进学生综合实验能力的培养;此外,本实验也可适当精简后作为基础性实验项目“丙酮碘化反应”的替代方案,能克服该实验中存在的反应速率较快不易记录实验数据、碘不易清洗污染比色皿等问题。 展开更多
关键词 催化光度法 伊文思蓝 表观速率常数 表观活化能
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鸟苷酸结合蛋白家族在感染性疾病中调控炎症小体活化的研究进展 被引量:2
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作者 全舒婷 焦伟伟 +3 位作者 徐放 孙琳 綦辉 申阿东 《遗传》 CAS CSCD 北大核心 2023年第11期1007-1017,共11页
鸟苷酸结合蛋白(guanylate-binding proteins,GBP)是一类干扰素诱导蛋白,在应对细菌、病毒、衣原体以及寄生虫等病原体感染时,其发挥的作用存在差异,并且影响感染性疾病的发展和结局。目前,研究者发现在细菌等病原体感染引发的细胞自主... 鸟苷酸结合蛋白(guanylate-binding proteins,GBP)是一类干扰素诱导蛋白,在应对细菌、病毒、衣原体以及寄生虫等病原体感染时,其发挥的作用存在差异,并且影响感染性疾病的发展和结局。目前,研究者发现在细菌等病原体感染引发的细胞自主免疫中,GBP蛋白通过影响炎症小体的经典和非经典活化途径调控细胞焦亡。本文对GBP家族成员结构、进化特征以及炎症小体的经典和非经典活化途径进行了介绍,综述了GBP蛋白调控炎症小体活化的相关研究进展,归纳总结了GBP蛋白影响不同病原体感染的作用机制,以期为感染性疾病的发病机制和诊疗提供新的基础研究线索。 展开更多
关键词 鸟苷酸结合蛋白 感染性疾病 炎症小体 炎症小体经典活化途径 炎症小体非经典活化途径
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Effect of Danhong injection on neuroendocrine molecules and ventricular remodeling in patients with ischemic cardiomyopathy heart failure
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作者 lin sun Wen-Jun Liu Shao-Juan Yu 《Journal of Hainan Medical University》 2017年第13期30-33,共4页
Objective:To study the effect of Danhong injection on neuroendocrine molecules and ventricular remodeling in patients with ischemic cardiomyopathy heart failure.Methods: 80 cases of patients with ischemic cardiomyopat... Objective:To study the effect of Danhong injection on neuroendocrine molecules and ventricular remodeling in patients with ischemic cardiomyopathy heart failure.Methods: 80 cases of patients with ischemic cardiomyopathy heart failure who were treated in our hospital between March 2014 and December 2016 were collected and divided into control group (n=40) and observation group (n=40) according to random number table. The control group received regular treatment, the observation group received regular + Danhong injection treatment, and both therapies lasted for 14 d a course, two sessions. Serum contents of neuroendocrine molecules and ventricular remodeling-related indexes, Doppler ultrasonic ventricular remodeling parameter levels, and so on were compared between two groups of patients before and after treatment.Results: Before treatment, serum contents of neuroendocrine molecules and ventricular remodeling-related indexes as well as Doppler ultrasonic ventricular remodeling parameter levels were not statistically different between two groups of patients. After treatment, serum neuroendocrine molecules NT-proBNP, ANP, AngⅡ, ALD and NE contents of observation group were lower than those of control group, serum ventricular remodeling indexes TGF-β1, NF-κB, CysC and FGF23 contents were lower than those of control group, and ultrasonic ventricular remodeling parameters LVMI, LVRI, RVEDV and RVESV levels were lower than those of control group.Conclusion: Adjuvant Danhong injection therapy helps optimize the neuroendocrine molecule contents and inhibit the ventricular remodeling process in patients with ischemic cardiomyopathy heart failure. 展开更多
关键词 ISCHEMIC CARDIOMYOPATHY Heart failure DANHONG injection NEUROENDOCRINE VENTRICULAR REMODELING
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Expert consensus on emergency procedures for portal hypertension bleeding(2022) 被引量:1
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作者 lin sun lin Long +1 位作者 Qing Wang Hua Xiang 《Journal of Interventional Medicine》 2023年第1期1-9,共9页
Expert consensus proposes an emergency treatment protocol for portal hypertension bleeding. Herein, the emergency treatment procedures, which include first aid, medical, interventional, and surgical treatments, are de... Expert consensus proposes an emergency treatment protocol for portal hypertension bleeding. Herein, the emergency treatment procedures, which include first aid, medical, interventional, and surgical treatments, are described. In addition, the indications, contraindications, operating norms, precautions, and prevention of complications of portal hypertension are described to optimize the first aid process. 展开更多
关键词 CONSENSUS Portal hypertension bleeding First aid process
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Responses of phytoplankton and its satellite bacteria to exogenous ethanol
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作者 Rediat ABATE Buce Hanoch HETHARUA +9 位作者 Vishal PATIL Daner lin Demeke KIFLE Junrong LIANG Changping CHEN lin sun Shuh-Ji KAO Yonghong BI Bangqin HUANG Yahui GAO 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第1期203-214,共12页
The response of phytoplankton and its satellite bacteria to various concentrations(0.01%-10%v/v)of ethanol is studied.To elucidate the effect of ethanol,single-strains of phytoplankton(SSP)culture,pure strains of sate... The response of phytoplankton and its satellite bacteria to various concentrations(0.01%-10%v/v)of ethanol is studied.To elucidate the effect of ethanol,single-strains of phytoplankton(SSP)culture,pure strains of satellite bacteria isolated from nonaxenic SSP cultures,and Escherichia coli were screened.Results indicate that ethanol could promote the growth and photo synthetic efficiency(F_(v)/F_(m))of S SP at 0.01%and the growth of satellite bacteria at 0.01%-1%.Nevertheless,ethanol inhibited the growth and F_(v)/F_(m)of SSP at 0.1%-1%,and killed bacteria and SSP at 10% concentration.Further investigation on a satellite bacterium(Mameliella alba)revealed that ethanol promotes growth by serving as a growth stimulant rather than a metabolic carbon source.The 16 S rRNA gene amplicon indicated that all nonaxenic S SP cultures harbor distinct satellite bacteria communities where the SSP culture of Skeletonema costatum,Phaeodactylum tricornutum,and Dunaliella bardawil were dominated by bacteria genera of Marivita(~80%),Dinoroseobacter(~47%),and Halomonas(~87%),respectively,indicating that every SSP cultures have their own distinct satellite bacterial community.The bacteria family Rhodobacteraceae was dominant in the two marine diatoms,whereas Halomonadaceae was dominant in the saline green microalga.Compared to their respective controls,the supply of 0.5% ethanol to SSP cultures promoted the growth of the satellite bacteria but did not cause a significant difference in species composition of satellite bacteria.Therefore,a low concentration of ethanol can promote the growth of bacteria in a non-selective way.This study enriched our knowledge about the effect of ethanol on aquatic microbes and provided a baseline for basic and applied biotechnological re search in the aquatic environment in the future. 展开更多
关键词 aquatic microbes bacteria diversity ethanol effect growth inhibition growth stimulation
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Development and application of multi-field coupled high-pressure triaxial apparatus for soil
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作者 Xiu-yan Wang lin sun +6 位作者 Shuai-wei Wang Ming-yu Wang Jin-qiu Li Wei-chao sun Jing-jing Wang Xi Zhu He Di 《Journal of Groundwater Science and Engineering》 2023年第3期308-316,共9页
The increasing severity of ground subsidence,ground fissure and other disasters caused by the excessive exploitation of deep underground resources has highlighted the pressing need for effective management.A significa... The increasing severity of ground subsidence,ground fissure and other disasters caused by the excessive exploitation of deep underground resources has highlighted the pressing need for effective management.A significant contributing factor to the challenges faced is the inadequacy of existing soil mechanics experimental instruments in providing effective indicators,creating a bottleneck in comprehensively understanding the mechanisms of land subsidence.It is urgent to develop a multi-field and multi-functional soil mechanics experimental system to address this issue.Based soil mechanics theories,the existing manufacturing capabilities of triaxial apparatus and the practical demands of the test system,a set of multi-field coupled high-pressure triaxial system is developed tailored for testing deep soils(at depths of approximately 3000 m)and soft rock.This system incorporates specialized design elements such as high-pressure chamber and horizontal deformation testing devices.In addition to the conventional triaxial tester functions,its distinctive feature encompass a horizontal deformation tracking measuring device,a water release testing device and temperature control device for the sample.This ensemble facilitates testing of horizontal and vertical deformation water release and other parameters of samples under a specified stress conditions,at constant or varying temperature ranging from-40℃–90℃.The accuracy of the tested parameters meets the requirements of relevant current specifications.The test system not only provides scientifically robust data for revealing the deformation and failure mechanism of soil subjected to extreme temperature,but also offers critical data support for major engineering projects,deep exploration and mitigation efforts related to soil deformation-induced disaster. 展开更多
关键词 Multi-field coupled triaxial test High and low temperature Horizontal deformation Compressed water release
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14例儿童肾结核的临床特征分析 被引量:1
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作者 郭琰 朱渝 +3 位作者 孙琳 祁雪 万雪梦 刘小荣 《结核病与肺部健康杂志》 2018年第4期251-254,共4页
目的分析儿童肾结核的临床特征,为儿童肾结核的早期诊断提供思路。方法回顾性分析2009年1月至2014年12月期间于首都医科大学附属北京儿童医院和四川大学华西第二医院(简称“两医院”)住院治疗且最终诊断为肾结核的14例患儿及其临床资料... 目的分析儿童肾结核的临床特征,为儿童肾结核的早期诊断提供思路。方法回顾性分析2009年1月至2014年12月期间于首都医科大学附属北京儿童医院和四川大学华西第二医院(简称“两医院”)住院治疗且最终诊断为肾结核的14例患儿及其临床资料,对患儿的基本资料、病史、临床表现、影像学特征等进行分析。结果14例肾结核患儿年龄中位数(四分位数)为9.5(9.3,12.7)岁,其中单纯肾结核3例,同时并发肺结核和其他部位的肺外结核者10例,肾结核并发肺结核者1例。自患儿出现症状至入两医院就诊的时间间隔为2.0(1.0,7.0)个月,就诊前14例患儿均于当地医院进行过诊治,5例于院外诊断为肺结核,2例诊断为肺外结核,2例诊断为肾结核,其余5例诊断为其他疾病。临床症状以低热最为常见(11例);3例患儿出现尿频、尿急、尿痛等尿道刺激征表现,肉眼血尿3例,腰痛1例;2例患儿有肾区叩痛。尿液抗酸杆菌涂片检测阳性1例,胃液阳性2例、痰液阳性1例。尿常规检查显示,5例患儿尿液潜血阳性,5例患儿尿蛋白阳性。11例患儿行肾脏B超肾盂造影检查,提示存在肾实质、肾盂积液、输尿管扩张等改变。结论儿童肾结核起病隐匿,常常并发其他部位结核,尿道刺激征表现不常见,难以早期诊断,往往造成病情的延误;影像学和实验室检查对于早期诊断疾病具有重要意义。 展开更多
关键词 儿童 结核 体征和症状 疾病特征 回顾性研究
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Analysis of Esophageal Cancer Death at Different Educational Levels in Inner Mongolia from 2009 to 2015
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作者 Rina Su Hao Wu +7 位作者 Fengqing Li Yan Zhang Huixia Li lin sun Sitana Ha Junjie An Chengyi Zhang Juan sun 《Health》 2021年第11期1270-1277,共8页
<strong>Objective: </strong>This study aimed to clarify the death characteristics of esophageal cancer in Inner Mongolia and the population distribution with various education levels. <strong>Methods... <strong>Objective: </strong>This study aimed to clarify the death characteristics of esophageal cancer in Inner Mongolia and the population distribution with various education levels. <strong>Methods:</strong> The mortality rate of esophageal cancer was calculated using the monitoring point of Death Registry System in Inner Mongolia from 2009 to 2015. The gender, age, region, ethnicity at two education levels of percentage were calculated and the <em>χ</em><sup>2</sup> test was executed. <strong>Result:</strong> The mortality rate of esophageal cancer was 10.10/105, China Adjustment Mortality was 10.97/10<sup>5</sup>, World Adjustment Mortality was 9.08/10<sup>5</sup> in Inner Mongolia. The death of esophageal cancer showed statistical significance at two educational levels (P < 0.05). High school and below accounted for 93.9% at the education level, and above high school accounted for 3.5%. In addition, there were significant differences in the percentage of death by gender, age and region at two educational levels (P < 0.05). <strong>Conclusion:</strong> Education level has a certain relation with the death of esophageal cancer. To improve the health level, health education plans can be formulated according to esophageal cancer prevention relevant policy with different education levels. 展开更多
关键词 Esophageal Cancer DEATH Education Level
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聚乳酸/聚丁二酸丁二醇酯/二苯基甲烷二异氰酸酯共混体系的结构与性能 被引量:3
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作者 余秋豪 单海霞 +3 位作者 黄宏魏 孙琳 余华燕 鲁圣军 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2020年第3期59-65,72,共8页
聚乳酸(PLA)的韧性差、稳定性不好使产业化生产受到局限,文中通过引入聚丁二酸丁二醇酯(PBS)来改善材料的性能,但是其相容性比较差,所以寻找了一种增容剂二苯基甲烷二异氰酸酯(MDI)来改善共混体系相容性。实验结果显示,聚乳酸性能得到... 聚乳酸(PLA)的韧性差、稳定性不好使产业化生产受到局限,文中通过引入聚丁二酸丁二醇酯(PBS)来改善材料的性能,但是其相容性比较差,所以寻找了一种增容剂二苯基甲烷二异氰酸酯(MDI)来改善共混体系相容性。实验结果显示,聚乳酸性能得到了极大改善。通过红外测试发现共混体系生成了聚氨酯;由扫描电镜可以看出,共混体系分散性得到了改善;从扭矩图可以看出,共混体系流动性得到了改善,共混体系塑化时间比纯PLA/PBS和纯PLA相比分别缩短33s和53s;通过力学性能测试,得知其断裂伸长率得到了极大提升,共混体系断裂伸长率比纯PLA/PBS和纯PLA分别提高了1.57倍和66倍。 展开更多
关键词 聚乳酸 聚丁二酸丁二醇酯 二苯基甲烷二异氰酸酯 α晶 流变行为
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