Clinical Study on the Treatment of Low Anal Fistula in Infants and Young Children by Anal Gland Excision and Virtual Hanging Procedure

Objective:To compare the efficacy of anal adenectomy with virtual hanging wire and anal fistulotomy in the treatment of low anal fistula in infants and children.Methods:60 children with low anal fistula who were admitted to our hospital from October 2021 to March 2022 and met the inclusion criteria were randomly divided into two groups of 30 cases each;the treatment group was treated with anal adenectomy and virtual hanging wire surgery,and the control group was treated with anal fistula resection.The clinical efficacy after treatment was compared.Results:The total effective rate of both groups was 96.67%and the difference between the two groups was not statistically significant(P>0.05).The postoperative pain score of the treatment group was lower than that of the control group(P<0.05).The length of hospitalization and healing time of the treatment group was lower than that of the control group(P<0.05).The anal function of the patients in both groups was normal,and there was no adverse reaction.Conclusion:Anal gland excision and virtual hanging surgery for the treatment of low anal fistula in infants and children have the advantages of mild pain,reduced length of hospitalization,short healing time,and better patient experience as compared to anal fistula excision.

教育数字化背景下基础化学实验教学中心质量建设提升

基础化学实验中心秉承目标导向,坚持立德树人,强化实验室安全教育,建立了多层次、立体化的课程教学体系和课程教学资源;建设一流课程,坚持学生中心,广泛开展讨论式、线上线下混合式、翻转课堂等课堂教学改革;指导学生参加学科竞赛和实验设计大赛,以赛代练,不断更新实验教学项目,推动实验教师教学能力提升。充分利用好实验这一实践教学主战场,适应新时代背景下化工类特色专业一流人才的培养需求,提高实验中心的育人能力,在全国同类高校处于领先水平。

Hydraulic modeling and optimization of jet mill bit considering the characteristics of depressurization and cuttings cleaning

A jet mill bit(JMB)is proposed to increase the drilling efficiency and safety of horizontal wells,which has the hydraulic characteristics of depressurization and cuttings cleaning.This paper fills the gap in the hydraulic study of the JMB by focusing on the hydraulic modeling and optimization of the JMB and considering these two hydraulic characteristics.First,the hydraulic depressurization model and the hydraulic cuttings cleaning model of the JMB are developed respectively.In the models,the pressure ratio and efficiency are chosen as the evaluation parameters of the depressurization capacity of the JMB,and the jet hydraulic power and jet impact force are chosen as the evaluation parameters of cuttings cleaning capacity of the JMB.Second,based on the hydraulic models,the effects of model parameters[friction loss coefficient,target inclination angle,rate of penetration(ROP),flow ratio,and well depth]on the hydraulic performance of the JMB are investigated.The results show that an increase in the friction loss coefficient and target inclination angle cause a significant reduction in the hydraulic depressurization capacity,and the effect of ROP is negligible.The flow ratio is positively related to the hydraulic cuttings cleaning capacity,and the well depth determines the maximum hydraulic cuttings cleaning capacity.Finally,by combining the hydraulic depressurization model and hydraulic cuttings cleaning model,an optimization method of JMB hydraulics is proposed to simultaneously maximize the jet depressurization capacity and the cuttings cleaning capacity.According to the drilling parameters given,the optimal values of the drilling fluid flow rate,backward nozzle diameter,forward nozzle diameter,and throat diameter can be determined.Moreover,a case study is conducted to verify the effectiveness of the optimization method.

Flexible and Robust Functionalized Boron Nitride/Poly(p‑Phenylene Benzobisoxazole)Nanocomposite Paper with High Thermal Conductivity and Outstanding Electrical Insulation

With the rapid development of 5G information technology,thermal conductivity/dissipation problems of highly integrated electronic devices and electrical equipment are becoming prominent.In this work,“high-temperature solid-phase&diazonium salt decomposition”method is carried out to prepare benzidine-functionalized boron nitride(m-BN).Subsequently,m-BN/poly(pphenylene benzobisoxazole)nanofiber(PNF)nanocomposite paper with nacremimetic layered structures is prepared via sol–gel film transformation approach.The obtained m-BN/PNF nanocomposite paper with 50 wt%m-BN presents excellent thermal conductivity,incredible electrical insulation,outstanding mechanical properties and thermal stability,due to the construction of extensive hydrogen bonds andπ–πinteractions between m-BN and PNF,and stable nacre-mimetic layered structures.Itsλ∥andλ_(⊥)are 9.68 and 0.84 W m^(-1)K^(-1),and the volume resistivity and breakdown strength are as high as 2.3×10^(15)Ωcm and 324.2 kV mm^(-1),respectively.Besides,it also presents extremely high tensile strength of 193.6 MPa and thermal decomposition temperature of 640°C,showing a broad application prospect in high-end thermal management fields such as electronic devices and electrical equipment.

A Study of a Moral Dilemma Stories Teaching Model Focusing on the Development of Higher-Order Thinking --"Synthetic polymers" as an example

Cultivating students'higher-order thinking is one of the important goals of modern education,and innovative teaching model is an effective way to achieve this goal.Aiming at the inadequacy of the existing moral dilemma stories approach in the transformation of knowledge and behavior,this research constructs a new Project Based Learning-Ethical Dilemma Stories(PBL-EDS)Teaching Model applicable to China's secondary education stage based on the innovative features of the moral dilemma stories approach on the core competencies,taking the chemistry subject as an example to carry out practice,and puts forward suggestions for the implementation of the teaching model.Chemistry as an example to carry out the practice,and suggestions are made for the implementation of the teaching model.

Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction

In the peripheral nervous system,the activation of Sirtuin 1 can improve insulin resistance;however,the role played by Sirtuin 1 in the central nervous system remains unknown.In this study,rat models of diabetes mellitus were generated by a single injection of streptozotocin.At 8 weeks after streptozotocin injection,the Morris water maze test and western blot assays confirmed that the diabetic model rats had learning and memory deficits,insulin resistance,and Sirtuin 1 expression could be detected in the hippocampus.Insulin and the insulin receptor inhibitor S961 were intranasally administered to investigate the regulatory effects of insulin signaling on Sirtuin 1.The results showed that insulin administration improved the impaired cognitive function of diabetic model rats and increased the expression levels of phosphorylated insulin receptor,phosphorylated insulin receptor substrate 1,and Sirtuin 1 in the hippocampus.Conversely,S961 administration resulted in more severe cognitive dysfunction and reduced the expression levels of phosphorylated insulin receptor,phosphorylated insulin receptor substrate 1,and Sirtuin 1.The Sirtuin 1 activator SRT2104 and the inhibitor Sirtinol were injected into the lateral ventricle,which revealed that the activation of Sirtuin 1 increased the expression levels of target of rapamycin complex 1,phosphorylated cAMP-response elementbinding protein,and brain-derived neurotrophic factor.Hippocampal dendritic length and spine density also increased in response to Sirtuin 1 activation.In contrast,Sirtinol decreased the expression levels of target of rapamycin complex 1,phosphorylated cAMP-response elementbinding protein,and brain-derived neurotrophic factor and damaged the dendritic structure.These findings suggest that the Sirtuin 1 signaling pathway plays an important role in the development of insulin resistance-related cognitive deficits in diabetic rats.This study was approved by the Animal Ethics Welfare Committee of the First Affiliated Hospital of Hunan University of Chinese Medicine(approval No.ZYFY201811207)in November 2018.

宫廷画家笔下的张栻

在中国文化史上,有关蜀人张栻的研究和文章可谓浩如烟海。然而,从图像学的角度,张栻的画像,包括面貌、特征、年代、写本、刻本等,在中国绘画艺术史中有着什么样的表现,则可以说还是一个无人涉足的学术空白。清代南薰殿所藏及与南薰殿绘画有关的四幅张栻的画像,是历代宫廷画家对张栻的相貌及气质的臆想或追摹。在过去几百年里,张栻的影响、身份、地位早已超越学术,通过中国绘画进入政治、宫廷和“配享”,其历史不但久远,而且影响深远。

Discussion on the clinical application of colorectal cancer based on the theory of "Tongqixiangqiu"

Objective:To explore the application of the theory of"Tongqixiangqiu"and its application in traditional Chinese medicine in order to find out the clinical application of colorectal cancer.Methods:Referring to the ancient medical works and modern literature on the theory of"Tongqixiangqiu",combined with the disease characteristics of colorectal cancer and the clinical experience of famous doctors in ancient and modern times,to explore its application in the clinical treatment of colorectal cancer.Results:The theory of"Tongqixiangqiu"has rich connotations,among which"anti-adjuvant therapy"and"lung and intestine combined treatment"are the representatives of the specific application of the theory.The methods of cold and heat counteraction,compatibility and external treatment as well as the idea of spleen deficiency and Qi stagnation type colorectal cancer pay attention to tonifying Fei qi,nourishing Fei yin,and promoting Sanjiao Qi mechanism play an important role in the differentiation and treatment of colorectal cancer in TCM.Conclusion:The theory of"Tongqixiangqiu"is widely used in the treatment of colorectal cancer,which has the advantages of significant curative effect,synergism and toxicity reduction,prolonging the survival period and improving the quality of life of patients.

张大千笔下的四川广元山水(上)

在中国绘画史上,有关张大千绘画作品的研究和文章可谓浩如烟海。不过,从专题的角度来研究张大千画过哪些关于故乡四川的山水作品的文章,目前极少;而对他在游历四川广元期间曾绘过什么作品,可以说几近空白。从文献记载或机构、私人收藏或拍卖公司拍卖的张大千描绘广元山水(嘉陵江、剑阁、剑门、明月峡、飞仙阁、西秦第一关、蜀山秦树)作品上的创作年代、题跋、来源、拍卖价格(部分)等方面予以初步梳理和考证,可看出张大千对蜀地山水充满深情与热爱。作为中国最伟大的画家之一,张大千用画笔对广元山水的描绘,对于广元的历史、文化等在全中国、全世界的传播,都有着非常重要的意义。

《注射用多黏菌素用于儿童的临床实践指南》计划书

为促进多黏菌素在儿童患者中的合理使用,山东省药学会立项,由山东第一医科大学附属省立医院牵头,参照《世界卫生组织指南制订手册》及卫生保健实践指南的报告规范(RIGHT)等标准与要求,组织全国相关领域知名专家编写《注射用多黏菌素用于儿童的临床实践指南》。本指南计划书主要介绍该指南的制订背景、目的与意义、应用人群、指南制作方法和流程,使指南编写全过程规范透明,通过全面的证据检索、规范的证据评价、科学的推荐意见形成方法,提高指南的严谨性和科学性。

Energy‐based analysis of seismic damage mechanism of multi‐anchor piles in tunnel crossing landslide area

To study the damage mechanism of multi‐anchor piles in tunnel crossing landslide area under earthquake,the damping performance of multi‐anchor piles was discussed.The energy dissipation springs were used as the optimization device of the anchor head to carry out the shaking table comparison test on the reinforced slope.The Hilbert spectrum and Hilbert marginal spectrum were proposed to analyze the seismic damage mechanism of the multi‐anchor piles,and the peak Fourier spectrum amplitude(PFSA)was used to verify the effectiveness of the method.The results show that the seismic energy is concentrated in the high‐frequency component(30-40Hz)of the Hilbert spectrum and the low‐frequency component(12-30 Hz)of the marginal spectrum.This indicates that they can be combined with the distribution law of the PFSA to identify the overall and local dynamic responses of the multi‐anchored piles,respectively.The stretchable deformation of the energy‐dissipation springs improves the coordination of the multi‐anchor piles,resulting in better pile integrity.The damage mechanism of the multi‐anchor piles is elucidated based on the energy method:local damage at the top and middle areas of the multi‐anchor piles is mainly caused by the low‐frequency component(12-30 Hz)of the marginal spectrum under the action of 0.15g and 0.20g seismic intensities.As the seismic intensity increases to 0.30g,the dynamic response of the slope is further amplified by the high‐frequency component(30-40 Hz)of the Hilbert energy spectrum,which leads to the overall damage of the multi‐anchor piles.

A method for correcting characteristic X-ray net peak count from drifted shadow peak

To correct spectral peak drift and obtain more reliable net counts,this study proposes a long short-term memory(LSTM)model fused with a convolutional neural network(CNN)to accurately estimate the relevant parameters of a nuclear pulse signal by learning of samples.A predefined mathematical model was used to train the CNN-LSTM model and generate a dataset composed of distorted pulse sequences.The trained model was validated using simulated pulses.The relative errors in the amplitude estimation of pulse sequences with different degrees of distortion were obtained using triangular shaping,CNN-LSTM,and LSTM models.As a result,for severely distorted pulses,the relative error of the CNN-LSTM model in estimating the pulse parameters was reduced by 14.35%compared with that of the triangular shaping algorithm.For slightly distorted pulses,the relative error of the CNN-LSTM model was reduced by 0.33%compared with that of the triangular shaping algorithm.The model was then evaluated considering two performance indicators,the correction ratio and the efficiency ratio,which represent the proportion of the increase in peak area of the two characteristic peak regions of interest(ROIs)to the peak area of the corrected characteristic peak ROI and the proportion of the increase in peak area of the two characteristic peak ROIs to the peak areas of the two shadow peak ROI,respectively.Ten measurement results of the iron ore samples indicate that approximately 86.27%of the decreased peak area of the shadow peak ROI was corrected to the characteristic peak ROI,and the proportion of the corrected peak area to the peak area of the characteristic peak ROI was approximately 1.72%.The proposed CNN-LSTM model can be applied to X-ray energy spectrum correction,which is of great significance for X-ray spectroscopy and elemental content analyses.

BioTreasury:a community-based repository enabling indexing and rating of bioinformatics tools

The exponential growth of bioinformatics tools in recent years has posed challenges for scientists in selecting the most suitable one for their data analysis assignments.Therefore,to aid scientists in making informed choices,a community-based platform that indexes and rates bioinformatics tools is urgently needed.In this study,we introduce Bio Treasury(http://biotreasury.rjmart.cn),an integrated communitybased repository that provides an interactive platform for users and developers to share their experiences in various bioinformatics tools.Bio Treasury offers a comprehensive collection of well-indexed bioinformatics software,tools,and databases,totaling over 10,000 entries.In the past two years,we have continuously improved and maintained Bio Treasury,adding several exciting features,including creating structured homepages for every tool and user,a hierarchical category of bioinformatics tools and classifying tools using large language model(LLM).Bio Treasury streamlines the tool submission process with intelligent auto-completion.Additionally,Bio Treasury provides a wide range of social features,for example,enabling users to participate in interactive discussions,rate tools,build and share tool collections for the public.We believe Bio Treasury can be a valuable resource and knowledge-sharing platform for the biomedical community.It empowers researchers to effectively discover and evaluate bioinformatics tools,fostering collaboration and advancing bioinformatics research.

Nanoparticle delivery for central nervous system diseases and its clinical application

In the treatment of central nervous system(CNS)diseases such as glioma,Alzheimer's disease(AD)and Parkinson's disease(PD),drugs are expected to reach specific areas of the brain to achieve the desired effect.Although a growing number of therapeutic targets have been identified in preclinical studies,the ones that can ultimately be used in the clinic are limited.Therefore,the research process and clinical application of drugs for treating CNS diseases are still large challenges.Physiological barriers such as the blood‒brain barrier(BBB)act as selective permeable membranes,allowing only certain molecules to enter the brain;this barrier is the major obstacle restricting the arrival of most drugs to brain lesions.Recently,nanoparticles,including lipid-based,cell-derived biomimetic,polymeric and inorganic nanoparticles,have gained increasing attention because of their ability to cross physiological barriers,and could play an important role as delivery carriers and immunomodulators.Additionally,clinical applications of nanoparticles in CNS diseases are underway.This review focuses on the progress of current research on the use of nanoparticles for the treatment of CNS diseases to provide additional insight into the treatment of CNS diseases.

乳腺癌发生模型MCF10各阶段细胞系中TIMP3基因启动子区甲基化分析

目的探讨抑癌基因TIMP3失活与乳腺癌发生和进展的关系。方法用甲基化特异性PCR技术和亚硫酸盐测序技术检测乳腺癌发生模型MCF10的增生细胞系MCF10A、癌前细胞系MCF10AT、导管内癌细胞系MCF10DCIS.com、浸润癌细胞系MCF10CA1a和转移癌细胞系MCF10CA1d、MCF10CA1h中TIMP3启动子区甲基化状态。结果甲基化特异性PCR分析显示,在上述各细胞系中,TIMP3启动子区均呈高度甲基化状态。亚硫酸盐测序显示,在上述各细胞系中,测序区内的68个CG位点几乎全部发生了甲基化,且甲基化累及了绝大部分等位基因。结论TIMP3基因启动子区甲基化在乳腺癌的发生和进展中起重要作用,可能成为早期诊断乳腺癌和判断乳腺癌预后的分子生物学标记。

乳腺癌发生过程中NOEY2基因启动子区甲基化及mRNA表达

目的探讨乳腺癌发生过程中抑癌基因NOEY2启动子区甲基化状态及其对mRNA表达的影响。方法应用甲基化特异性PCR及双亚硫酸钠基因测序技术检测MCF10模型中乳腺增生细胞系MCF10A、癌前细胞系MCF10AT、导管内癌细胞系MCF10DC IS.com、浸润癌细胞系MCF10CA1 a、MCF10CA1d、MCF10CA1h及正常乳腺组织中NOEY2基因启动子区CpG岛I甲基化状态,然后用RT-PCR和实时PCR技术检测上述样品的mRNA表达水平。结果MCF10模型的增生细胞系、癌前细胞系、导管内癌细胞系、浸润癌细胞系均发生该基因启动子区CpG岛I高度甲基化;与正常乳腺组织相比,上述细胞系mRNA表达显著减少。结论NOEY2基因启动子区高度甲基化及相应的mRNA表达减少是乳腺癌发生过程中的早期事件,与乳腺癌发生有关,可能成为早期诊断乳腺癌的潜在分子生物学标记。

Protective Effects of Polyphenol Extracts from Sea Buckthorn (Hippophaë rhamnoides L.) on Rat Hearts

The objective of present study was to investigate the antioxidative and cardioprotective effects of polyphenol extracts from sea buckthorn (PESB) against myocardial ischemia reperfusion injury (MIRI). PESB was analyzed using HPLC-DAD and their antioxidant activities were evaluated by measuring the intrinsic free radicals cavenging capacity and inhibiting the formation of hydroxyl radical capacity. Experiments on the isolated rat hearts were carried out according to the improved Langendorff retrograde perfusion technology. Coronary effluent of lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CK-MB) activities were analyzed to determine the extent of myocardial injury. Protein expression levels of Beclin-1, microtubule-associated protein 1 light chain 3 (LC3) I and II were measured to evaluate the degree of autophagy. In conclusion, coupled results from both in vivo and in vitro experiments have confirmed that PESB has potential health implications in both prevention and amelioration of MIRI, which may be attributed to the inhibition of autophagy.

不同分层体系结构钨酸铋对可见光催化降解诺氟沙星的影响（英文）

研究不同分层体系结构钨酸铋对可见光催化降解诺氟沙星的影响。在pH值为4~11条件下采用水热法反应合成钨酸铋。结果表明:在pH值为4条件下制备的钨酸铋对诺氟沙星具有很好的吸附和光催化性能。表征结果显示,pH值为4时制备的钨酸铋具有较大的比表面积和光生载流子分离效率。在弱碱条件下,催化降解速率达到最大,这是由于弱碱溶液提供了足量的OH^-,光子与材料表面吸附的OH^-反应生成了羟基自由基。本实验证明,较小尺寸的超薄钨酸铋是一种有效的诺氟星沙污染水体光催化剂。

王羲之与四川

王羲之一生中从未来过巴蜀地区,但是他的传世草书代表作《十七帖》中有部分涉及蜀地四川。通过对王羲之《十七帖》的解读,可以看出书者为什么如此关注严君平、司马相如、扬子云(扬雄)、谯周等四川历史名人;为什么如此关注秦代的成都城池、蜀中的汉代学堂、汉代壁画以及四川盐井等蜀地风物古迹;从而回答他为什么如此渴望来蜀地,并将“登汶岭、峨眉而归”视为一件不朽盛事的个中原因。王羲之真迹《十七帖》,是中国书法史上第一次就四川历史人物、山川风物而由名家书写并流传至今的名家墨宝,堪称国宝,是今天打造四川的文化品牌、挖掘四川文化资源的艺术宝库。

基于PBL的物理化学实验混合教学模式的设计与实践

依托自建物理化学实验在线开放课程及网络教学资源,在物理化学实验课程中开展了线上线下混合式教学。“以问题为导向,以学生为中心”设计课程教学,开展探究式学习和过程性评价。通过课前线上预习、线下课堂教学和课后答疑指导等环节,实现了学生能力的进阶式培养,提高学生的自主学习能力、综合能力和创新能力。为高等学校实验类课程线上线下混合式教学模式的探索提供了范式。