Bone is an endocrine organ involved in modulating glucose homeostasis. The role of the bone formation marker osteocalcin(OCN) in predicting diabetes was reported, but with conflicting results. No study has explored th...Bone is an endocrine organ involved in modulating glucose homeostasis. The role of the bone formation marker osteocalcin(OCN) in predicting diabetes was reported, but with conflicting results. No study has explored the association between baseline bone resorption activity and incident diabetes or prediabetes during follow-up. Our objective was to examine the relationship between the baseline bone resorption marker crosslinked C-telopeptide of type I collagen(CTX) and glycemic dysregulation after 4 years. This longitudinal study was conducted in a university teaching hospital. A total of 195 normal glucose tolerant(NGT) women at baseline were invited for follow-up. The incidence of diabetes and prediabetes(collectively defined as dysglycemia) was recorded. A total of 128 individuals completed the 4-year study. The overall conversion rate from NGT to dysglycemia was 31.3%. The incidence of dysglycemia was lowest in the middle tertile [16.3%(95% confidence interval(CI), 6.8%–30.7%)] compared with the lower [31.0%(95%CI, 17.2%–46.1%)] and upper [46.5%(95% CI, 31.2%–62.6%)] tertiles of CTX, with a significant difference seen between the middle and upper tertiles(P = 0.002 5). After adjusting for multiple confounding variables, the upper tertile of baseline CTX was associated with an increased risk of incident dysglycemia, with an odds ratio of 7.09(95% CI, 1.73–28.99) when the middle tertile was the reference. Osteoclasts actively regulate glucose homeostasis in a biphasic model that moderately enhanced bone resorption marker CTX at baseline provides protective effects against the deterioration of glucose metabolism, whereas an overactive osteoclastic function contributes to an increased risk of subsequent dysglycemia.展开更多
In a recent paper(Luo H et al.,2022),we found that the peak amplitudes of diurnal magnetic variations,measured during martian days(sols)at the InSight landing site,exhibited quasi Carrington-Rotation(qCR)periods at hi...In a recent paper(Luo H et al.,2022),we found that the peak amplitudes of diurnal magnetic variations,measured during martian days(sols)at the InSight landing site,exhibited quasi Carrington-Rotation(qCR)periods at higher eigenmodes of the natural orthogonal components(NOC);these results were based on~664 sols of magnetic field measurements.However,the source of these periodic variations is still unknown.In this paper we introduce the neutral-wind driven ionospheric dynamo current model(e.g.,Lillis et al.,2019)to investigate the source.Four candidates-the draped IMF,electron density/plasma density,the neutral densities,and the electron temperature in the ionosphere with artificial qCR periodicity,are applied in the modeling to find the main factor likely to be causing the observed surface magnetic field variations that exhibit the same qCR periods.Results show that the electron density/plasma density,which controls the total conductivity in the dynamo region,appears to account for the greatest part of the surface qCR variations;its contribution reaches about 67.6%.The draped IMF,the neutral densities,and the electron temperature account,respectively,for only about 12.9%,10.3%,and 9.2%of the variations.Our study implies that the qCR magnetic variations on the Martian surface are due primarily to variations of the dynamo currents caused by the electron density variations.We suggest also that the timevarying fields with the qCR period could be used to probe the Martian interior's electrical conductivity structure to a depth of at least 700 km.展开更多
Most of the existing vector data matching methods use traditional feature geometry attribute features to match, however, many of the similarity indicators are not suitable for cross-scale data, resulting in less accur...Most of the existing vector data matching methods use traditional feature geometry attribute features to match, however, many of the similarity indicators are not suitable for cross-scale data, resulting in less accuracy in identifying objects. In order to solve this problem effectively, a deep learning model for vector road data matching is proposed based on siamese neural network and VGG16 convolutional neural network, and matching experiments are carried out. Experimental results show that the proposed vector road data matching model can achieve an accuracy of more than 90% under certain data support and threshold conditions.展开更多
Hepatobiliary tumor(HBT),one of the leading causes of cancer deaths globally,is more frequent in East Asia including China[1].HBT includes liver cancer,cholangiocarcinoma and gallbladder cancer.HBT burden varies marke...Hepatobiliary tumor(HBT),one of the leading causes of cancer deaths globally,is more frequent in East Asia including China[1].HBT includes liver cancer,cholangiocarcinoma and gallbladder cancer.HBT burden varies markedly by gender and geographic region due to the exposure of risk factors.Majority of the hepatocellular carcinomas are associated with hepatitis B-type virus infection[2],and approximate 70%patients were male in China.Other risk factors include infections(hepatitis C virus),aflatoxins,flukes in endemic areas,behavioral factors(alcohol,tobacco),metabolic factors(diabetes,obesity)and congenital disease(bile duct cyst).The pathogenesis of HBTs are complex and HBTs possess high-level tumor heterogeneity(both intra-and intertumor)[3,4],it is important to conduct a comprehensive assessment for every patient before making decision in treatment,which needs multidisciplinary management efforts.展开更多
Super-high resolution laser-based angle-resolved photoemission measurements are carried out on LiFeAs superconductor to investigate its electron dynamics. Three energy scales at ~ 20 meV, ~ 34 meV, and ~ 55 meV are re...Super-high resolution laser-based angle-resolved photoemission measurements are carried out on LiFeAs superconductor to investigate its electron dynamics. Three energy scales at ~ 20 meV, ~ 34 meV, and ~ 55 meV are revealed for the first time in the electron self-energy both in the superconducting state and normal state. The ~ 20 meV and ~ 34 meV scales can be attributed to the coupling of electrons with sharp bosonic modes which are most likely phonons. These observations provide definitive evidence on the existence of mode coupling in iron-based superconductors.展开更多
High and stable yield is the main goal of soybean genetic improvement.In this study,association analysis was used to detect the quantitative trait loci(QTL)for the plant height,and soybean growth period using 182 SSR ...High and stable yield is the main goal of soybean genetic improvement.In this study,association analysis was used to detect the quantitative trait loci(QTL)for the plant height,and soybean growth period using 182 SSR markers in the RIL population of 136 F_(4:8) lines,which developed from a cross between photoperiod-insensitive cultivar‘Dongnong 47’and photoperiod-sensitive variety PI317334–B.The results showed that 33 QTLs related to soybean growth period and plant height traits were detected by compound interval mapping,and were located on 12 linkage groups including N,C1,C2,J,D1a,B2,E,G,A2,O,L,I,with the contribution rate of 7.85–33.84%.These QTL loci and linkage markers related to soybean photoperiod sensitivity,would be helpful to identify key genes that control soybean photoperiod sensitivity,and provide an important basis for the breeding of new photoperiod-insensitive soybean varieties based on molecular design breeding.展开更多
Objective:To explore the anti-tumor of breast cancer metastasis suppressor 1(BRMS1)on renal cell carcinoma.Methods:BRSM1 stabilized overexpressed and knockdown cell models were constructed to detect the effect of BRMS...Objective:To explore the anti-tumor of breast cancer metastasis suppressor 1(BRMS1)on renal cell carcinoma.Methods:BRSM1 stabilized overexpressed and knockdown cell models were constructed to detect the effect of BRMS1 overexpression and knockdown on viability rate of 769-P cells.Activation of PI3K/AKT-mTOR-NFκB signaling pathway,expression of cellular apoptosis-related proteins,DNA damage repair-related proteins and angiogenesis-related proteins were detected using Western blotting analysis.Results:The viability rate of 769-P cells were significantly decreased in BRMS1 overexpression cells while significantly increased in BRMS1 knockdown cells(P<0.05).The activity of PI3K/AKT-mTOR-NFκB signaling pathway was significantly inhibited with BRMS1 overexpression(P<0.05),and expression of BAX was significantly increased with significantly decreased expression of Bcl-2(P<0.05).Besides,BRMS1 overexpression could significantly decrease the expression of DNA damage repair-related proteins and angiogenesis and cell-matrix degradation related proteins(P<0.05).Conclusion:BRMS1 induces apoptosis of renal cell carcinoma and performs an anti-tumor effect via inhibition of PI3K/AKT-mTOR-NFκB signaling pathway,expression of DNA damage repair-related proteins and angiogenesis-related proteins.展开更多
BACKGROUND Gastric cancer(GC)has high morbidity and mortality.Moreover,because GC has no typical symptoms in the early stages,most cases are already in the advanced stages by the time the symptoms appear,thus resultin...BACKGROUND Gastric cancer(GC)has high morbidity and mortality.Moreover,because GC has no typical symptoms in the early stages,most cases are already in the advanced stages by the time the symptoms appear,thus resulting in poor prognosis and a low survival rate.Endoscopic submucosal dissection(ESD)can realize the early detection and diagnosis of GC and become the main surgical method for early GC.However,ESD has a steep learning curve and high technical skill requirements for endoscopists,which is not conducive to its widespread implementation and advancement.Therefore,a series of auxiliary techniques have been derived.AIM To evaluate the safety and efficacy of magnetic anchor technique(MAT)-assisted ESD in early GC.METHODS This was an ex vivo animal experiment.The experimental models were the isolated stomachs of pigs,which were divided into two groups,namely the study group(n=6)with MAT-assisted ESD and the control group(n=6)with traditional ESD.Comparing the total surgical time,incidence of surgical complications,complete mucosal resection rate,specimen size,and the scores of endoscopist’s satisfaction with the procedure reflected their feelings about convenience during the surgical procedure between the two groups.The magnetic anchor device for auxiliary ESD in the study group comprised three parts,an anchor magnet(AM),a target magnet(TM),and a soft tissue clip.Under gastroscopic guidance,the soft tissue clip and the TM were delivered to the pre-marked mucosal lesion through the gastroscopic operating hole.The soft tissue clip and the TM were connected by a thin wire through the TM tail structure.The soft tissue clip was released by manipulating the operating handle of the soft tissue clip in a way that the soft tissue clip and the TM were fixed to the lesion mucosa.In vitro,ESD is aided by maneuvering the AM such that the mucosal dissection surface is exposed.RESULTS The total surgical time was shorter in the study group than in the control group(26.57±0.19 vs 29.97±0.28,P<0.001),and the scores of endoscopist’s satisfaction with the procedure were higher in the study group than in the control group(9.53±0.10 vs 8.00±0.22,P<0.001).During the operation in the study group,there was no detachment of the soft tissue clip and TM and no mucosal tearing.The magnetic force between the AM and TM provided good mucosal exposure and sufficient tissue tension for ESD.The mucosal lesion was completely peeled off,and the operation was successful.There were no significant differences in the incidence of surgical complications(100%vs 83.3%),complete mucosal resection rate(100%vs 66.7%,P=0.439),and specimen size(2.44±0.04 cm vs 2.49±0.02,P=0.328)between the two groups.CONCLUSION MAT-ESD is safe and effective for early GC.It provides a preliminary basis for subsequent internal animal experiments and clinical research.展开更多
Circular RNAs can regulate the development and progression of ischemic cerebral disease.However,it remains unclear whether they play a role in acute ischemic stroke.To investigate the role of the circular RNA Rap1b(ci...Circular RNAs can regulate the development and progression of ischemic cerebral disease.However,it remains unclear whether they play a role in acute ischemic stroke.To investigate the role of the circular RNA Rap1b(circRap1b)in acute ischemic stroke,in this study we established an in vitro model of acute ischemia and hypoxia by subjecting HT22 cells to oxygen and glucose deprivation and a mouse model of acute ischemia and hypoxia by occluding the right carotid artery.We found that circRap1b expression was remarkably down-regulated in the hippocampal tissue of the mouse model and in the HT22 cell model.In addition,Hoxa5 expression was strongly up-regulated in response to circRap1b overexpression.Hoxa5 expression was low in the hippocampus of a mouse model of acute ischemia and in HT22-AIS cells,and inhibited HT22-AIS cell apoptosis.Importantly,we found that circRap1b promoted Hoxa5 transcription by recruiting the acetyltransferase Kat7 to induce H3K14ac modification in the Hoxa5 promoter region.Hoxa5 regulated neuronal apoptosis by activating transcription of Fam3a,a neuronal apoptosis-related protein.These results suggest that circRap1b regulates Hoxa5 transcription and expression,and subsequently Fam3a expression,ultimately inhibiting cell apoptosis.Lastly,we explored the potential clinical relevance of circRap1b and Hoxa5 in vivo.Taken together,these findings demonstrate the mechanism by which circRap1b inhibits neuronal apoptosis in acute ischemic stroke.展开更多
Thousands of lakes on the Tibetan Plateau(TP) play a critical role in the regional water cycle, weather, and climate. In recent years, the areas of TP lakes underwent drastic changes and have become a research hotspot...Thousands of lakes on the Tibetan Plateau(TP) play a critical role in the regional water cycle, weather, and climate. In recent years, the areas of TP lakes underwent drastic changes and have become a research hotspot. However, the characteristics of the lake-atmosphere interaction over the high-altitude lakes are still unclear, which inhibits model development and the accurate simulation of lake climate effects. The source region of the Yellow River(SRYR) has the largest outflow lake and freshwater lake on the TP and is one of the most densely distributed lakes on the TP. Since 2011,three observation sites have been set up in the Ngoring Lake basin in the SRYR to monitor the lake-atmosphere interaction and the differences among water-heat exchanges over the land and lake surfaces. This study presents an eight-year(2012–19), half-hourly, observation-based dataset related to lake–atmosphere interactions composed of three sites. The three sites represent the lake surface, the lakeside, and the land. The observations contain the basic meteorological elements,surface radiation, eddy covariance system, soil temperature, and moisture(for land). Information related to the sites and instruments, the continuity and completeness of data, and the differences among the observational results at different sites are described in this study. These data have been used in the previous study to reveal a few energy and water exchange characteristics of TP lakes and to validate and improve the lake and land surface model. The dataset is available at National Cryosphere Desert Data Center and Science Data Bank.展开更多
The synergistic effect of total ionizing dose(TID) and single event gate rupture(SEGR) in SiC power metal–oxide–semiconductor field effect transistors(MOSFETs) is investigated via simulation. The device is found to ...The synergistic effect of total ionizing dose(TID) and single event gate rupture(SEGR) in SiC power metal–oxide–semiconductor field effect transistors(MOSFETs) is investigated via simulation. The device is found to be more sensitive to SEGR with TID increasing, especially at higher temperature. The microscopic mechanism is revealed to be the increased trapped charges induced by TID and subsequent enhancement of electric field intensity inside the oxide layer.展开更多
基金supported by projects from the National Natural Science Foundation of China(81370977,81570796 and 81370018)by the Shanghai Science and Technology Committee(14411960900)
文摘Bone is an endocrine organ involved in modulating glucose homeostasis. The role of the bone formation marker osteocalcin(OCN) in predicting diabetes was reported, but with conflicting results. No study has explored the association between baseline bone resorption activity and incident diabetes or prediabetes during follow-up. Our objective was to examine the relationship between the baseline bone resorption marker crosslinked C-telopeptide of type I collagen(CTX) and glycemic dysregulation after 4 years. This longitudinal study was conducted in a university teaching hospital. A total of 195 normal glucose tolerant(NGT) women at baseline were invited for follow-up. The incidence of diabetes and prediabetes(collectively defined as dysglycemia) was recorded. A total of 128 individuals completed the 4-year study. The overall conversion rate from NGT to dysglycemia was 31.3%. The incidence of dysglycemia was lowest in the middle tertile [16.3%(95% confidence interval(CI), 6.8%–30.7%)] compared with the lower [31.0%(95%CI, 17.2%–46.1%)] and upper [46.5%(95% CI, 31.2%–62.6%)] tertiles of CTX, with a significant difference seen between the middle and upper tertiles(P = 0.002 5). After adjusting for multiple confounding variables, the upper tertile of baseline CTX was associated with an increased risk of incident dysglycemia, with an odds ratio of 7.09(95% CI, 1.73–28.99) when the middle tertile was the reference. Osteoclasts actively regulate glucose homeostasis in a biphasic model that moderately enhanced bone resorption marker CTX at baseline provides protective effects against the deterioration of glucose metabolism, whereas an overactive osteoclastic function contributes to an increased risk of subsequent dysglycemia.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB41010304)the National Key R&D Program of China (Grant No.2018YFC1503806)the National Natural Science Foundation of China (41874080, 41674168, 41874197)
文摘In a recent paper(Luo H et al.,2022),we found that the peak amplitudes of diurnal magnetic variations,measured during martian days(sols)at the InSight landing site,exhibited quasi Carrington-Rotation(qCR)periods at higher eigenmodes of the natural orthogonal components(NOC);these results were based on~664 sols of magnetic field measurements.However,the source of these periodic variations is still unknown.In this paper we introduce the neutral-wind driven ionospheric dynamo current model(e.g.,Lillis et al.,2019)to investigate the source.Four candidates-the draped IMF,electron density/plasma density,the neutral densities,and the electron temperature in the ionosphere with artificial qCR periodicity,are applied in the modeling to find the main factor likely to be causing the observed surface magnetic field variations that exhibit the same qCR periods.Results show that the electron density/plasma density,which controls the total conductivity in the dynamo region,appears to account for the greatest part of the surface qCR variations;its contribution reaches about 67.6%.The draped IMF,the neutral densities,and the electron temperature account,respectively,for only about 12.9%,10.3%,and 9.2%of the variations.Our study implies that the qCR magnetic variations on the Martian surface are due primarily to variations of the dynamo currents caused by the electron density variations.We suggest also that the timevarying fields with the qCR period could be used to probe the Martian interior's electrical conductivity structure to a depth of at least 700 km.
文摘Most of the existing vector data matching methods use traditional feature geometry attribute features to match, however, many of the similarity indicators are not suitable for cross-scale data, resulting in less accuracy in identifying objects. In order to solve this problem effectively, a deep learning model for vector road data matching is proposed based on siamese neural network and VGG16 convolutional neural network, and matching experiments are carried out. Experimental results show that the proposed vector road data matching model can achieve an accuracy of more than 90% under certain data support and threshold conditions.
基金supported by grants from the “919 Tumor Pre-cision Medicine Public Welfare Foundation”the International Sci-ence and Technology Cooperation Projects(2015DFA30650 and 2016YFE0107100)+2 种基金Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences(CIFMS)(2017-I2M-4-003)the Capital Special Research Project for the Clinical Application(Z151100004015170)Beijing Natural Science Foundation Haid-ian Joint Fund Frontier Project(L172055)
文摘Hepatobiliary tumor(HBT),one of the leading causes of cancer deaths globally,is more frequent in East Asia including China[1].HBT includes liver cancer,cholangiocarcinoma and gallbladder cancer.HBT burden varies markedly by gender and geographic region due to the exposure of risk factors.Majority of the hepatocellular carcinomas are associated with hepatitis B-type virus infection[2],and approximate 70%patients were male in China.Other risk factors include infections(hepatitis C virus),aflatoxins,flukes in endemic areas,behavioral factors(alcohol,tobacco),metabolic factors(diabetes,obesity)and congenital disease(bile duct cyst).The pathogenesis of HBTs are complex and HBTs possess high-level tumor heterogeneity(both intra-and intertumor)[3,4],it is important to conduct a comprehensive assessment for every patient before making decision in treatment,which needs multidisciplinary management efforts.
基金Project supported by the National Key Research and Development Program of China(Grant Nos.2016YFA0300300,2016YFA0300600,2017YFA0302900,2018YFA0704200,2018YFA0305600,and 2019YFA0308000)the National Natural Science Foundation of China(Grant Nos.11888101,11922414,and 11874405)+2 种基金the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant Nos.XDB25000000 and XDB33010300)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.2017013)the Research Program of Beijing Academy of Quantum Information Sciences(Grant No.Y18G06)。
文摘Super-high resolution laser-based angle-resolved photoemission measurements are carried out on LiFeAs superconductor to investigate its electron dynamics. Three energy scales at ~ 20 meV, ~ 34 meV, and ~ 55 meV are revealed for the first time in the electron self-energy both in the superconducting state and normal state. The ~ 20 meV and ~ 34 meV scales can be attributed to the coupling of electrons with sharp bosonic modes which are most likely phonons. These observations provide definitive evidence on the existence of mode coupling in iron-based superconductors.
基金This study was conducted in the Key Laboratory of Soybean Biology of Chinese Education Ministry,and financially supported by National Natural Science Foundation of China(32072086,31771820)Heilongjiang Province Natural Science Foundation(ZD2020C002).
文摘High and stable yield is the main goal of soybean genetic improvement.In this study,association analysis was used to detect the quantitative trait loci(QTL)for the plant height,and soybean growth period using 182 SSR markers in the RIL population of 136 F_(4:8) lines,which developed from a cross between photoperiod-insensitive cultivar‘Dongnong 47’and photoperiod-sensitive variety PI317334–B.The results showed that 33 QTLs related to soybean growth period and plant height traits were detected by compound interval mapping,and were located on 12 linkage groups including N,C1,C2,J,D1a,B2,E,G,A2,O,L,I,with the contribution rate of 7.85–33.84%.These QTL loci and linkage markers related to soybean photoperiod sensitivity,would be helpful to identify key genes that control soybean photoperiod sensitivity,and provide an important basis for the breeding of new photoperiod-insensitive soybean varieties based on molecular design breeding.
基金This study was supported by Tianjin Municipal Science and Technology Project(Grant No.16ZXHLSY00120).
文摘Objective:To explore the anti-tumor of breast cancer metastasis suppressor 1(BRMS1)on renal cell carcinoma.Methods:BRSM1 stabilized overexpressed and knockdown cell models were constructed to detect the effect of BRMS1 overexpression and knockdown on viability rate of 769-P cells.Activation of PI3K/AKT-mTOR-NFκB signaling pathway,expression of cellular apoptosis-related proteins,DNA damage repair-related proteins and angiogenesis-related proteins were detected using Western blotting analysis.Results:The viability rate of 769-P cells were significantly decreased in BRMS1 overexpression cells while significantly increased in BRMS1 knockdown cells(P<0.05).The activity of PI3K/AKT-mTOR-NFκB signaling pathway was significantly inhibited with BRMS1 overexpression(P<0.05),and expression of BAX was significantly increased with significantly decreased expression of Bcl-2(P<0.05).Besides,BRMS1 overexpression could significantly decrease the expression of DNA damage repair-related proteins and angiogenesis and cell-matrix degradation related proteins(P<0.05).Conclusion:BRMS1 induces apoptosis of renal cell carcinoma and performs an anti-tumor effect via inhibition of PI3K/AKT-mTOR-NFκB signaling pathway,expression of DNA damage repair-related proteins and angiogenesis-related proteins.
基金Supported by the Key Research&Development Program-Social Development of Shaanxi Province of China,No.2021SF-163the Innovation Capability Support Plan of Shaanxi Province of China,No.2020KJXX-022.
文摘BACKGROUND Gastric cancer(GC)has high morbidity and mortality.Moreover,because GC has no typical symptoms in the early stages,most cases are already in the advanced stages by the time the symptoms appear,thus resulting in poor prognosis and a low survival rate.Endoscopic submucosal dissection(ESD)can realize the early detection and diagnosis of GC and become the main surgical method for early GC.However,ESD has a steep learning curve and high technical skill requirements for endoscopists,which is not conducive to its widespread implementation and advancement.Therefore,a series of auxiliary techniques have been derived.AIM To evaluate the safety and efficacy of magnetic anchor technique(MAT)-assisted ESD in early GC.METHODS This was an ex vivo animal experiment.The experimental models were the isolated stomachs of pigs,which were divided into two groups,namely the study group(n=6)with MAT-assisted ESD and the control group(n=6)with traditional ESD.Comparing the total surgical time,incidence of surgical complications,complete mucosal resection rate,specimen size,and the scores of endoscopist’s satisfaction with the procedure reflected their feelings about convenience during the surgical procedure between the two groups.The magnetic anchor device for auxiliary ESD in the study group comprised three parts,an anchor magnet(AM),a target magnet(TM),and a soft tissue clip.Under gastroscopic guidance,the soft tissue clip and the TM were delivered to the pre-marked mucosal lesion through the gastroscopic operating hole.The soft tissue clip and the TM were connected by a thin wire through the TM tail structure.The soft tissue clip was released by manipulating the operating handle of the soft tissue clip in a way that the soft tissue clip and the TM were fixed to the lesion mucosa.In vitro,ESD is aided by maneuvering the AM such that the mucosal dissection surface is exposed.RESULTS The total surgical time was shorter in the study group than in the control group(26.57±0.19 vs 29.97±0.28,P<0.001),and the scores of endoscopist’s satisfaction with the procedure were higher in the study group than in the control group(9.53±0.10 vs 8.00±0.22,P<0.001).During the operation in the study group,there was no detachment of the soft tissue clip and TM and no mucosal tearing.The magnetic force between the AM and TM provided good mucosal exposure and sufficient tissue tension for ESD.The mucosal lesion was completely peeled off,and the operation was successful.There were no significant differences in the incidence of surgical complications(100%vs 83.3%),complete mucosal resection rate(100%vs 66.7%,P=0.439),and specimen size(2.44±0.04 cm vs 2.49±0.02,P=0.328)between the two groups.CONCLUSION MAT-ESD is safe and effective for early GC.It provides a preliminary basis for subsequent internal animal experiments and clinical research.
基金supported by the Natural Science Foundation of Liaoning Province,No.2021-MS-061(to LZhang)。
文摘Circular RNAs can regulate the development and progression of ischemic cerebral disease.However,it remains unclear whether they play a role in acute ischemic stroke.To investigate the role of the circular RNA Rap1b(circRap1b)in acute ischemic stroke,in this study we established an in vitro model of acute ischemia and hypoxia by subjecting HT22 cells to oxygen and glucose deprivation and a mouse model of acute ischemia and hypoxia by occluding the right carotid artery.We found that circRap1b expression was remarkably down-regulated in the hippocampal tissue of the mouse model and in the HT22 cell model.In addition,Hoxa5 expression was strongly up-regulated in response to circRap1b overexpression.Hoxa5 expression was low in the hippocampus of a mouse model of acute ischemia and in HT22-AIS cells,and inhibited HT22-AIS cell apoptosis.Importantly,we found that circRap1b promoted Hoxa5 transcription by recruiting the acetyltransferase Kat7 to induce H3K14ac modification in the Hoxa5 promoter region.Hoxa5 regulated neuronal apoptosis by activating transcription of Fam3a,a neuronal apoptosis-related protein.These results suggest that circRap1b regulates Hoxa5 transcription and expression,and subsequently Fam3a expression,ultimately inhibiting cell apoptosis.Lastly,we explored the potential clinical relevance of circRap1b and Hoxa5 in vivo.Taken together,these findings demonstrate the mechanism by which circRap1b inhibits neuronal apoptosis in acute ischemic stroke.
基金supported by the National Natural Science Foundations of China (Grant Nos. 41930759, 41822501, 42075089, 41975014)the 2nd Scientific Expedition to the Qinghai-Tibet Plateau (2019QZKK0102)+3 种基金The Science and Technology Research Plan of Gansu Province (20JR10RA070)the Chinese Academy of Youth Innovation and Promotion, CAS (Y201874)the Youth Innovation Promotion Association CAS (QCH2019004)iLEAPs (Integrated Land Ecosystem-Atmosphere Processes Study-iLEAPS)。
文摘Thousands of lakes on the Tibetan Plateau(TP) play a critical role in the regional water cycle, weather, and climate. In recent years, the areas of TP lakes underwent drastic changes and have become a research hotspot. However, the characteristics of the lake-atmosphere interaction over the high-altitude lakes are still unclear, which inhibits model development and the accurate simulation of lake climate effects. The source region of the Yellow River(SRYR) has the largest outflow lake and freshwater lake on the TP and is one of the most densely distributed lakes on the TP. Since 2011,three observation sites have been set up in the Ngoring Lake basin in the SRYR to monitor the lake-atmosphere interaction and the differences among water-heat exchanges over the land and lake surfaces. This study presents an eight-year(2012–19), half-hourly, observation-based dataset related to lake–atmosphere interactions composed of three sites. The three sites represent the lake surface, the lakeside, and the land. The observations contain the basic meteorological elements,surface radiation, eddy covariance system, soil temperature, and moisture(for land). Information related to the sites and instruments, the continuity and completeness of data, and the differences among the observational results at different sites are described in this study. These data have been used in the previous study to reveal a few energy and water exchange characteristics of TP lakes and to validate and improve the lake and land surface model. The dataset is available at National Cryosphere Desert Data Center and Science Data Bank.
基金Project supported by the National Natural Science Foundation of China(Grant No.12004329)Open Project of State Key Laboratory of Intense Pulsed Radiation Simulation and Effect(Grant No.SKLIPR2115)+1 种基金Postgraduate Research and Practice Innovation Program of Jiangsu Province(Grant No.SJCX22_1704)Innovative Science and Technology Platform Project of Cooperation between Yangzhou City and Yangzhou University,China(Grant Nos.YZ202026301 and YZ202026306)。
文摘The synergistic effect of total ionizing dose(TID) and single event gate rupture(SEGR) in SiC power metal–oxide–semiconductor field effect transistors(MOSFETs) is investigated via simulation. The device is found to be more sensitive to SEGR with TID increasing, especially at higher temperature. The microscopic mechanism is revealed to be the increased trapped charges induced by TID and subsequent enhancement of electric field intensity inside the oxide layer.
