Effects of secretory IgA on inflammatory response and immune function indicators in children with upper respiratory tract infection

Objective:To investigate the effects of secretory IgA on the inflammatory response and immune function indicators in children with upper respiratory tract infection.Methods:A total of 80 children with recurrent upper respiratory tract infection who received treatment in our hospital between September 2017 and September 2018 were retrospectively analyzed and divided into the control group(n=43)receiving conventional anti-infective drug therapy and the sIgA group(n=37)receiving secretory IgA combined with conventional anti-infective drug therapy according to the treatment regimen.The differences in serum contents of inflammatory cytokines and immunoglobulins as well as peripheral blood levels of Th1/Th2 immune response indexes were compared between the two groups before treatment and after 7 days of treatment.Results:Before treatment,there were no significant differences in serum contents of inflammatory cytokines and immunoglobulins or peripheral blood levels of Th1/Th2 immune response indexes between the two groups.After 7 days of treatment,serum inflammatory cytokines tumor necrosis factor-α,interleukin-2 and interleukin-18 contents of the sIgA group were lower than those of the control group;serum immunoglobulin IgE content was lower than that of the control group,while IgG2 and IgG4 contents were higher than those of the control group;peripheral blood Th1 cell distribution proportion and Th1/Th2 ratio were higher than those of the control group,while Th2 cell distribution proportion was lower than that of the control group.Conclusion:Conventional anti-infective drugs combined with secretory IgA can further inhibit the inflammatory response and balance the immune response in children with recurrent upper respiratory tract infections.