Inflammatory bowel disease(IBD)is a chronic inflammatory disease thought to be mediated by the microbiota of the intestinal lumen and inappropriate immune responses.Aberrant immune responses can cause secretion of har...Inflammatory bowel disease(IBD)is a chronic inflammatory disease thought to be mediated by the microbiota of the intestinal lumen and inappropriate immune responses.Aberrant immune responses can cause secretion of harmful cytokines that destroy the epithelium of the gastrointestinal tract,leading to further inflammation.Interleukin(IL)-22 is a member of the IL-10 family of cytokines that was recently discovered to be mainly produced by both adaptive and innate immune cells.Several cytokines and many of the transcriptional factors and T regulatory cells are known to regulate IL-22 expression through activation of signal transducer and activator of transcription 3signaling cascades.This cytokine induces antimicrobial m olecules and proliferative and antiapoptoic pathways,which help prevent tissue damage and aid in its repair.All of these processes play a beneficial role in IBD by enhancing intestinal barrier integrity and epithelial innate immunity.In this review,we discuss recent progress in the involvement of IL-22in the pathogenesis of IBD,as well as its therapeutic potential.展开更多
目的:探讨IL-10、IL-13、IL-4Rα、FcεRIβ、IFNGR2、CYP3A4基因多态性与中国西北地区汉族人群β-内酰胺类抗生素过敏易感性的关联性。创新点:首次在甘肃地区汉族人群中探讨10个单核苷酸多态性位点与β-内酰胺类抗生素过敏易感性的关联...目的:探讨IL-10、IL-13、IL-4Rα、FcεRIβ、IFNGR2、CYP3A4基因多态性与中国西北地区汉族人群β-内酰胺类抗生素过敏易感性的关联性。创新点:首次在甘肃地区汉族人群中探讨10个单核苷酸多态性位点与β-内酰胺类抗生素过敏易感性的关联性,为该地区人群β-内酰胺类抗生素过敏患者提供了基因组学水平的诊断数据。方法:以β-内酰胺类抗生素过敏者为研究对象进行病例对照研究,采用Sequenom Mass ARRAY分子量阵列技术平台定制单核苷酸多态性(SNP)芯片检测10个单核苷酸多态性与甘肃地区汉族人群β-内酰胺类抗生素过敏易感性的关联性。应用SHEsis软件完成IL-10及IL-13的连锁不平衡分析及单倍型构建。结论:CYP3A4 rs2242480基因多态性与男性患者β-内酰胺类抗生素过敏有显著的相关性(P=0.022;OR=0.167,95%CI:0.032–0.867)。IL-13的CCT及CAC单倍型与中国西北地区汉族β-内酰胺类抗生素过敏的相关性有待进一步研究。展开更多
基金Supported by National Natural Science Foundation of China,No.81070288 and No.81270452Medical Science and Technology Foundation of Henan Province,No.201001004Science and Technology Leader Overseas Training Foundation of Henan Province,No.201201013
文摘Inflammatory bowel disease(IBD)is a chronic inflammatory disease thought to be mediated by the microbiota of the intestinal lumen and inappropriate immune responses.Aberrant immune responses can cause secretion of harmful cytokines that destroy the epithelium of the gastrointestinal tract,leading to further inflammation.Interleukin(IL)-22 is a member of the IL-10 family of cytokines that was recently discovered to be mainly produced by both adaptive and innate immune cells.Several cytokines and many of the transcriptional factors and T regulatory cells are known to regulate IL-22 expression through activation of signal transducer and activator of transcription 3signaling cascades.This cytokine induces antimicrobial m olecules and proliferative and antiapoptoic pathways,which help prevent tissue damage and aid in its repair.All of these processes play a beneficial role in IBD by enhancing intestinal barrier integrity and epithelial innate immunity.In this review,we discuss recent progress in the involvement of IL-22in the pathogenesis of IBD,as well as its therapeutic potential.
基金This study was supported by grants from the Innovation of Science and Technology Commission of Shenzhen Municipality （JCYJ20140418095735538, JCYJ20120613161724279 JCYJ20120613172559904+3 种基金 JCYJ20130329110735981 JCYJ20120613173233810） International Collaboration Project （GJHZ20130408174112021） and the National Nature Science Foundation and China （81373176）.
基金Project supported by the Natural Science Foundation of Gansu Province,China(Nos.3ZS061-A25-084 and 1208RJZA192)the Key Laboratory of Digestive System Tumors of Gansu Provincethe Fundamental Research Funds for the Central Universities(No.lzujbky-2011-t03-15),China
文摘目的:探讨IL-10、IL-13、IL-4Rα、FcεRIβ、IFNGR2、CYP3A4基因多态性与中国西北地区汉族人群β-内酰胺类抗生素过敏易感性的关联性。创新点:首次在甘肃地区汉族人群中探讨10个单核苷酸多态性位点与β-内酰胺类抗生素过敏易感性的关联性,为该地区人群β-内酰胺类抗生素过敏患者提供了基因组学水平的诊断数据。方法:以β-内酰胺类抗生素过敏者为研究对象进行病例对照研究,采用Sequenom Mass ARRAY分子量阵列技术平台定制单核苷酸多态性(SNP)芯片检测10个单核苷酸多态性与甘肃地区汉族人群β-内酰胺类抗生素过敏易感性的关联性。应用SHEsis软件完成IL-10及IL-13的连锁不平衡分析及单倍型构建。结论:CYP3A4 rs2242480基因多态性与男性患者β-内酰胺类抗生素过敏有显著的相关性(P=0.022;OR=0.167,95%CI:0.032–0.867)。IL-13的CCT及CAC单倍型与中国西北地区汉族β-内酰胺类抗生素过敏的相关性有待进一步研究。
