Gossypol,a phenolic compound found in the cotton plant,is widely distributed in cottonseed byproducts.Although ruminant animals are believed to be more tolerant of gossypol toxicity than monogastric animals due to rum...Gossypol,a phenolic compound found in the cotton plant,is widely distributed in cottonseed byproducts.Although ruminant animals are believed to be more tolerant of gossypol toxicity than monogastric animals due to rumen microbial fermentation,the actual mechanisms of detoxification remain unclear.In contrast,the metabolic detoxification of gossypol by Helicoverpa armigera(Lepidoptera:Noctuidae)larvae has achieved great advances.The present review discusses the clinical signs of go ssypol in ruminant animals,as well as summarizing advances in the study of gossypol detoxification in the rumen.It also examines the regulatory roles of several key enzymes in gossypol detoxification and transformation known in H.armigera.With the rapid development of modern molecular biotechnology and-omics technology strategies,evidence increasingly indicates that research into the biological degradation of gossypol in H.armigera larvae and some microbes,in terms of these key enzymes,could provide scientific insights that would underpin future work on microbial gossypol detoxification in the rumen,with the ultimate aim of further alleviating gossypol toxicity in ruminant animals.展开更多
基金supported by the National Key Technology R&D Program of China(No.2013BAD10B04)the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions(No.CIT&TCD20130324),China
基金Project supported by the National Natural Science Foundation of China(No.31272478)the National Twelve-Five Technological Supported Plan of China(No.2013BAD10B04)+1 种基金the Ministry of Agriculture,Public Service Sectors Agriculture Research Projects(No.201403051-07)the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions(No.CIT&TCD20130324),China
基金supported by the Key Research and Development Project of Ningxia Hui Autonomous Region(2018BBF33006)National Dairy Industry and Technology System grant number CARS-36。
文摘Gossypol,a phenolic compound found in the cotton plant,is widely distributed in cottonseed byproducts.Although ruminant animals are believed to be more tolerant of gossypol toxicity than monogastric animals due to rumen microbial fermentation,the actual mechanisms of detoxification remain unclear.In contrast,the metabolic detoxification of gossypol by Helicoverpa armigera(Lepidoptera:Noctuidae)larvae has achieved great advances.The present review discusses the clinical signs of go ssypol in ruminant animals,as well as summarizing advances in the study of gossypol detoxification in the rumen.It also examines the regulatory roles of several key enzymes in gossypol detoxification and transformation known in H.armigera.With the rapid development of modern molecular biotechnology and-omics technology strategies,evidence increasingly indicates that research into the biological degradation of gossypol in H.armigera larvae and some microbes,in terms of these key enzymes,could provide scientific insights that would underpin future work on microbial gossypol detoxification in the rumen,with the ultimate aim of further alleviating gossypol toxicity in ruminant animals.
