Machine learning model based on non-convex penalized huberized-SVM

The support vector machine(SVM)is a classical machine learning method.Both the hinge loss and least absolute shrinkage and selection operator(LASSO)penalty are usually used in traditional SVMs.However,the hinge loss is not differentiable,and the LASSO penalty does not have the Oracle property.In this paper,the huberized loss is combined with non-convex penalties to obtain a model that has the advantages of both the computational simplicity and the Oracle property,contributing to higher accuracy than traditional SVMs.It is experimentally demonstrated that the two non-convex huberized-SVM methods,smoothly clipped absolute deviation huberized-SVM(SCAD-HSVM)and minimax concave penalty huberized-SVM(MCP-HSVM),outperform the traditional SVM method in terms of the prediction accuracy and classifier performance.They are also superior in terms of variable selection,especially when there is a high linear correlation between the variables.When they are applied to the prediction of listed companies,the variables that can affect and predict financial distress are accurately filtered out.Among all the indicators,the indicators per share have the greatest influence while those of solvency have the weakest influence.Listed companies can assess the financial situation with the indicators screened by our algorithm and make an early warning of their possible financial distress in advance with higher precision.

Genome sequencing and population genomics modeling provide insights into the local adaptation of weeping forsythia

Understanding the genetic basis underlying the local adaptation of nonmodel species is a fundamental goal in evolutionary biology.In this study,we explored the genetic mechanisms of the local adaptation of Forsythia suspensa using genome sequence and population genomics data obtained from specific-locus amplified fragment sequencing.We assembled a high-quality reference genome of weeping forsythia(Scaffold N50=7.3 Mb)using ultralong Nanopore reads.Then,genome-wide comparative analysis was performed for 15 natural populations of weeping forsythia across its current distribution range.Our results revealed that candidate genes associated with local adaptation are functionally correlated with solar radiation,temperature and water variables across heterogeneous environmental scenarios.In particular,solar radiation during the period of fruit development and seed drying after ripening,cold,and drought significantly contributed to the adaptive differentiation of F.suspensa.Natural selection exerted by environmental factors contributed substantially to the population genetic structure of F.suspensa.Our results supported the hypothesis that adaptive differentiation should be highly pronounced in the genes involved in signal crosstalk between different environmental variables.Our population genomics study of F.suspensa provides insights into the fundamental genetic mechanisms of the local adaptation of plant species to climatic gradients.

Bloodletting Cupping Therapy for postherpetic neuralgia:a systematic review and meta-analysis

Objective:To evaluate the clinical effects of bloodletting cupping therapy(BCT)for patients with postherpetic neuralgia.Methods:We comprehensively searched four Chinese databases(Wanfang,China National Knowledge Infrastructure,VIP Database for Chinese Technical Periodicals,China Biology Medicine disc)and foreign databases(Pubmed,Cochrane Library).The retrieval time was from the build-up time to May 2018.RevMan 5.3 software was used for statistical analysis.Results:We finally obtained 18 eligible studies.Compared with routine western medicine,BCT can significantly improve PHN(OR=7.45,95%CI,3.36-16.51,Z=4.95,P<0.01).BCT plus other methods of acupuncture with fire needle and filiform needle has significant therapeutic effect(OR=5.54,95%CI,3.01-10.19,P<0.01),BCT plus routine western medicine has significant therapeutic effect(OR=4.99,95%CI,2.73-9.11,P<0.00001).Conclusion:It showed that the therapeutic effects of BCT,BCT plus other acupuncture methods with fire needle and filiform needle,and BCT combined with western medicine are better than those treated with single western medicine.It is effective to treat postherpetic neuralgia with Bloodletting Cupping Therapy.

Mechanism analysis of Traditional Chinese Medicine in treatment of Diabetic Nephropathy based on network pharmacology and Traditional Chinese Medicine inheritance support system

糖尿病肾病为糖尿病最为严重的并发症之一,早期以水肿、蛋白尿为主要临床表现,后期随着病情发展严重者则会出现肾小球硬化及肾间质纤维化,预后差,目前中医药在治疗糖尿病肾病方面有一定的优势。目前关于中医药治疗糖尿病肾病的研究越来越多,但大多集中于研究糖尿病肾病的中医分型及病因病机的总结,缺少针对中药处方作用机制的深入研究与归纳整理。本文采用中医传承系统及网络药理学BATMAN-TCM软件,搜集整理相关文献,对近十年来经临床实践及动物实验验证对治疗糖尿病肾病的确有显著疗效的中医药处方进行分析,研究其核心用药配伍规律及治疗糖尿病肾病的潜在作用信号通路和靶点。研究发现,中医药治疗糖尿病肾病的核心中药配伍味山茱萸、茯苓、山药三味中药,此配伍富集与糖尿病肾病的信号传导通路及靶点有密切的联系,并且对蛋白尿、糖代谢紊乱、水肿等临床症状的改善有积极作用,深入探讨核心配伍山茱萸、茯苓、山药三味中药对糖尿病肾病的治疗效果,以期为中医药治疗糖尿病肾病的研究及临床治疗提供参考。

Genetic and Epigenetic Diversities Shed Light on Domestication of Cultivated Ginseng （Panax ginseng）

Chinese ginseng （Panaxginseng） is a medically important herb within Panax and has crucial cultural values in East Asia. As the symbol of traditional Chinese medicine, Chinese ginseng has been used as a herbal remedy to restore stamina and capacity in East Asia for thousands of years. To address the evolutionary origin and domestication history of cultivated ginseng, we employed multiple molecular approaches to investigate the genetic structures of cultivated and wild ginseng across their distribution ranges in northeastern Asia. Phylogenetic and population genetic analyses revealed that the four cultivated ginseng landraces, COMMON, BIANTIAO, SHIZHU, and GAOLI （also known as Korean ginseng）, were not domesticated independently and Fusong Town is likely one of the primary domestication centers. In addition, our results from population genetic and epigenetic analyses demonstrated that cultivated ginseng maintained high levels of genetic and epigenetic diversity, but showed distinct cytosine methylation patterns compared with wild ginseng. The patterns of genetic and epigenetic variation revealed by this study have shed light on the domestication history of cultivated ginseng, which may serve as a framework for future genetic improvements.

Clinical Application of the UK Working Party＇s Criteria for the Diagnosis of Atopic Dermatitis in the Chinese Population by Age Group

Background： Atopic dermatitis （AD） is a common inflammatory skin disease with an increasingly significant prevalence. The prevalence of AD depends greatly on how its diagnosis is done. The UK Working Party＇s diagnostic criteria for AD are simple and easy to apply without invasive laboratory tests. This study assessed the clinical utility of these criteria in China. Methods： Data were collected from 6208 patients at 31 tertiary hospitals in 13 Chinese provinces/municipalities from March 2014 to May 2014.. The agreement between the UK diagnostic criteria and the clinical records for AD was assessed by Cohen＇s kappa. Results： The overall agreement between the UK diagnostic criteria and clinical diagnosis was fair （kappa = 0.40）. A slightly better agreement was found in patients aged between 4 and 9 years （kappa = 0.48）, while fair agreement was found in the group 〈4 years and the group ≥10 years （kappa = 0.27 and 0.39, respectively）. Using the UK party＇s criteria as the standard, the sensitivity, specificity, positive predictive value, and negative predictive value of the clinical diagnosis of AD were 62.3%, 89.2%, 38.0%, and 95.7%, respectively. Conclusions： Our study indicates a modest ability among Chinese dermatologists to apply the UK Working Party＇s diagnostic criteria for AD, especially in patients aged 〈4 years and ≥10 years. Since there is no gold standard for AD diagnosis, it is important to determine how AD is identified when evaluating a diagnostic tool.

Clinical and Genetic Features of Familial Cold Urticaria： A Report of Three Families

To the Editor：Cold urticaria （CU） accounts for 1-3% of all urticaria cases.Affected patients develop a rash and/or angioedema after physical exposure to cold agents such as cold water,air,or food.CU can be classified as an acquired or familial disorder.Familial CU （FCU） was first described in 1940.Three familial cold syndromes exist：familial delayed CU,familial cold autoinflammatory syndrome （FCAS）,and familial atypical CU （FACU）.[1] Here,we report three Chinese pedigrees of FCU with an autosomal dominant inheritance pattern [Figure 1a].

Laboratory Safety of Dupilumab,and Its Effect on Inflammatory Biomarkers,in Chinese Adults With Moderate-to-Severe Atopic Dermatitis:An Analysis of a Randomized,Double-Blind Phase III Study

Objective:Limited information is available on the use of dupilumab for the treatment of atopic dermatitis(AD)in the Chinese population.Methods:We analyzed laboratory data from a previously published randomized,double-blind phase III trial(NCT03912259)to provide further insight into the safety of dupilumab in Chinese adults with moderate to severe AD.The trial participants received either 300 mg of dupilumab or placebo every 2 weeks for 16 weeks.Hematology,blood chemistry,serum thymus and activation-regulated chemokine(TARC),and total immunoglobulin E(IgE)were evaluated.Results:In total,82 participants received dupilumab and 83 received placebo.With the exception of eosinophil counts of>0.8×109/L,which were found less frequently with dupilumab(9.8%)than with placebo(18.7%),the hematology and blood chemistry values were generally stable in both treatment groups.There were no clinically significant differences between the dupilumab and placebo groups,and no participants developed treatment-emergent abnormalities of potential clinical significance.However,compared with placebo,greater decreases in serum lactate dehydrogenase(mean change,−97.4 vs.−33.5 IU/L),TARC(median percent change,−78.6%vs.−30.8%),and total IgE(median percent change,−53.4%vs.−0.2%)were observed with dupilumab than placebo at week 16.Conclusion:Dupilumab demonstrated a favorable laboratory safety profile in Chinese adults with moderate to severe AD.

Chinese Expert Consensus on Clinical Application of Patch Test (Revised 2020)

Allergic contact dermatitis is a common clinical allergic disease.The patch test is the gold standard for finding and clarifying contact allergens.With the deepening understanding of the epidemiology,pathogenesis,and clinical manifestations of contact dermatitis,as well as the increased requirements for the standardized application of patch tests,the relevant consensus needs to be continuously updated.This consensus is updated on the basis of the version issued in 2015.In this revised version,it refines the selection of clinical indications,improves the judgment end interpretation of results,adds delayed detection and patient education,and so on,which aims to further standardize clinical applications and improve the value of patch test.

Ion exchange coupled biomineral self-sacrificial template synthesis of N-enriched porous carbon as robust electrocatalyst for rechargeable Zn-air battery

To realize the commercialize of rechargeable Zn-air battery(RZAB),developing metal-free bifunctional electrocatalysts with satisfactory activity for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is one of the emerging issues.Herein,a prawn shells-derived N-enriched porous carbon(PSNC)is synthesized via an ion exchange coupled biomimetic selfsacrificing template strategy.The resulting PSNC displays unique functional components,including the interconnected macro-meso-micropores structure to shorten charge and mass transfer pathway,high content of pyridinic and graphitic nitrogen to construct rich catalytic active site and improve conductivity.As electrocatalysts in alkaline condition,the optimized PSNC-0.8 achieves excellent bifunctional catalytic propriety with a narrow potential gap(ΔE)value of 0.80 V.Meanwhile,PSNC-0.8-based RZAB displays a high peak power density of 176.5 mW·cm^(-2)and considerable cycling durability with a small battery efficiency delay of 6.5%after 480 cycles(320 h).This study enlightens a simple and effective conception to design high-performance metal-free bifunctional electrocatalysts from seafood waste.

Genome sequences of five Sitopsis species of Aegilops and the origin of polyploid wheat B subgenome

Common wheat(Triticum aestivum,BBAADD)is a major staple food crop worldwide.The diploid progenitors of the A and D subgenomes have been unequivocally identified;that of B,however,remains ambiguous and controversial but is suspected to be related to species of Aegilops,section Sitopsis.Here,we report the assembly of chromosome-level genome sequences of all five Sitopsis species,namely Aegilops bicornis,Ae.longissima,Ae.searsii,Ae.sharonensis,and Ae.speltoides,as well as the partial assembly of the Amblyopyrum muticum(synonym Aegilops mutica)genome for phylogenetic analysis.Our results reveal that the donor of the common wheat B subgenome is a distinct,and most probably extinct,diploid species that diverged from an ancestral progenitor of the B lineage to which the still extant Ae.speltoides and Am.muticum belong.In addition,we identified interspecific genetic introgressions throughout the evolution of the Triticum/Aegilops species complex.The five Sitopsis species have various assembled genome sizes(4.11-5.89 Gb)with high proportions of repetitive sequences(85.99%-89.81%);nonetheless,they retain high collinearity with other genomes or subgenomes of species in the Triticum/Aegilops complex.Differences in genome size were primarily due to independent post-speciation amplification of transposons.We also identified a set of Sitopsis genes pertinent to important agronomic traits that can be harnessed for wheat breeding.These newly assembled genome resources provide a new roadmap for evolutionary and genetic studies of the Triticum/Aegilops complex,as well as for wheat improvement.

Effects of CO2 fractional laser on hair growth in C57BL/6 mice and potential underlying mechanisms

To the Editor: Hair loss or alopecia is a very common disease, which has the potential to impact the quality of life, physical attractiveness, and interpersonal relationships. In recent years, lasers and light therapy have been used as alternative or supplementary therapy for hair loss. In 2007, low-level laser therapy was approved by the United States Food and Drug Administration as a safe and effective treatment on hair loss.