Inflammation after stroke is the main cause of cerebral ischemia/reperfusion injury. Cascading events after injury can lead to cell death. Heat shock protein 70 and other endogenous injury-signaling molecules are rele...Inflammation after stroke is the main cause of cerebral ischemia/reperfusion injury. Cascading events after injury can lead to cell death. Heat shock protein 70 and other endogenous injury-signaling molecules are released by damaged cells, which can lead to systemic stress reactions. Protecting the brain through repair begins with the stress-injury-repair signaling chain. This study aimed to verify whether acupuncture acts through this chain to facilitate effective treatment of ischemic stroke. Rat models of cerebral ischemia/reperfusion injury were established by Zea Longa＇s method, and injury sites were identified by assessing neurological function, 2,3,5-triphenyltetrazolium chloride staining, and hematoxylin-eosin staining. Electroacupuncture at acupoints Baihui（DU20） and Zusanli（ST36） was performed in the model rats with dilatational waves, delivered for 20 minutes a day at 2–100 Hz and an amplitude of 2 m A. We analyzed the blood serum from the rats and found that inflammatory cytokines affected the levels of adrenotrophin and heat shock protein 70, each of which followed a similar bimodal curve. Specifically, electroacupuncture lowered the peak levels of adrenocorticotrophic hormone and heat shock protein 70. Thus, electroacupuncture was able to inhibit excessive stress, reduce inflammation, and promote the repair of neurons, which facilitated healing of ischemic stroke.展开更多
We use the Landau-Lifshitz-Gilbert equation to investigate field-driven domain wall propagation in magnetic nan- otubes. We find that the distortion is maximum as the time becomes infinite and the exact rigid-body sol...We use the Landau-Lifshitz-Gilbert equation to investigate field-driven domain wall propagation in magnetic nan- otubes. We find that the distortion is maximum as the time becomes infinite and the exact rigid-body solutions are obtained analytically. We also find that the velocity increases with increasing the ratio of inner radius and outer radius. That is to say, we can accelerate domain wall motion not only by increasing the magnetic field, but also by reducing the thickness of the nanotubes.展开更多
基金supported by a grant from the Major Science and Technology Project "Major New Drug Created" Funding,No.2009ZX09103-707
文摘Inflammation after stroke is the main cause of cerebral ischemia/reperfusion injury. Cascading events after injury can lead to cell death. Heat shock protein 70 and other endogenous injury-signaling molecules are released by damaged cells, which can lead to systemic stress reactions. Protecting the brain through repair begins with the stress-injury-repair signaling chain. This study aimed to verify whether acupuncture acts through this chain to facilitate effective treatment of ischemic stroke. Rat models of cerebral ischemia/reperfusion injury were established by Zea Longa＇s method, and injury sites were identified by assessing neurological function, 2,3,5-triphenyltetrazolium chloride staining, and hematoxylin-eosin staining. Electroacupuncture at acupoints Baihui（DU20） and Zusanli（ST36） was performed in the model rats with dilatational waves, delivered for 20 minutes a day at 2–100 Hz and an amplitude of 2 m A. We analyzed the blood serum from the rats and found that inflammatory cytokines affected the levels of adrenotrophin and heat shock protein 70, each of which followed a similar bimodal curve. Specifically, electroacupuncture lowered the peak levels of adrenocorticotrophic hormone and heat shock protein 70. Thus, electroacupuncture was able to inhibit excessive stress, reduce inflammation, and promote the repair of neurons, which facilitated healing of ischemic stroke.
基金Project supported by the National Natural Science Foundation of China(Grant No.61774001)the National Social Science Foundation of China(Grant No.17BJY103)+2 种基金the Key Project of Scientific and Technological Research in Hebei Province,China(Grant No.ZD2015133)the Construction Project of Graduate Demonstration Course in Hebei Province,China(Grant No.94/220079)supported by the Natural Science Foundation of Hunan Province,China(Grant No.2017JJ2045)
文摘We use the Landau-Lifshitz-Gilbert equation to investigate field-driven domain wall propagation in magnetic nan- otubes. We find that the distortion is maximum as the time becomes infinite and the exact rigid-body solutions are obtained analytically. We also find that the velocity increases with increasing the ratio of inner radius and outer radius. That is to say, we can accelerate domain wall motion not only by increasing the magnetic field, but also by reducing the thickness of the nanotubes.
