铁调素与肾性贫血相关影响因素的研究进展

慢性肾脏病(chronic kidney disease,CKD)的全球患病率是8%~16%。贫血是CKD的主要并发症之一。引起肾性贫血有多种因素,如红细胞生成素(erythropoietin,EPO)不足、缺铁、失血、炎症、缺乏维生素D、铁调素、继发性甲状旁腺功能亢进(secondary hyperparathyroidism,SHPT)及肥胖等。其中引起肾性贫血的主要原因是红细胞生成素不足及铁的缺乏。因此,肾性贫血的治疗主要是红细胞生成刺激剂(erythropoiesis stimulater agent,ESA)的使用和补铁。最新研究发现铁调素(hepcidin)与肾性贫血关系密切,可能与机体的铁状态、炎症状态及肾小球滤过率(glomeralar filtration rate,GFR)等相关。尤其在功能性缺铁中发挥重要调节作用,本文综述了铁调素与肾性贫血的相关影响因素,对临床治疗及研究肾性贫血提供了基础。

Design and Synthesis of Novel Aryloxyalkyl-arylpiperazine Derivatives as α_(1A)-Adrenoceptor Antagonists

A series of 1-[2-(substituted phenoxy)ethyl]-4-(2-methoxyphenyl)-piperazine deriva- tives have been synthesized. The radioligand receptor binding assay indicated that most of them bind with α1-adrenoceptor specifically, and one of the compound possessed subtype A selectivity.