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Overexpression of Bax sensitizes prostate cancer cells to TGF-β induced apoptosis 被引量:2
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作者 PeiHuiLIN ZuiPAN +3 位作者 linzheng NaLI DavidDANIELPOUR JianJieMA 《Cell Research》 SCIE CAS CSCD 2005年第3期160-166,共7页
NRP-154 is a tumorigenic epithelial cell line derived from the preneoplastic dorsal-lateral prostate of rats. These cells are exquisitely sensitive to TGF-β induced apoptosis. In contrast, we find that NRP-154 cells ... NRP-154 is a tumorigenic epithelial cell line derived from the preneoplastic dorsal-lateral prostate of rats. These cells are exquisitely sensitive to TGF-β induced apoptosis. In contrast, we find that NRP-154 cells can sustain overexpression of exogenous Bax protein, which is different from non-tumor cells where Bax functions as a ubiquitous stimulator of apoptosis. NRP-154 cells stably overexpressing Bax show increased sensitivity to TGF-β induced apoptosis. The degree of TGF-β induced apoptosis displays high correlation with cleavage of Bax at the amino-terminus. Our data indicate that prostate cancer cells can host high levels of latent Bax which can be activated through post-translational modification. 展开更多
关键词 NRP-154 cells prostate cancer BAX TGF-Β apoptosis.
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