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放射性核素分子成像在肿瘤精准诊疗中的临床应用 被引量:2
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作者 韩兆国 阿荣 +6 位作者 王竞 刘想 乔丽娜 柯明星 关正其 邬哲溪 孙夕林 《中国肿瘤临床》 CAS CSCD 北大核心 2021年第21期1100-1106,共7页
肿瘤的诊疗理念经历了从经验医学到循证医学的过渡,已步入“精准医学”的发展阶段。在精准医学中,精准诊断是指导临床决策、制定个体化诊治方案的重要依据,是实施精准治疗的必要前提。然而,由于恶性肿瘤具有时空异质性,给肿瘤精准诊断... 肿瘤的诊疗理念经历了从经验医学到循证医学的过渡,已步入“精准医学”的发展阶段。在精准医学中,精准诊断是指导临床决策、制定个体化诊治方案的重要依据,是实施精准治疗的必要前提。然而,由于恶性肿瘤具有时空异质性,给肿瘤精准诊断带来挑战,严重制约了肿瘤精准医疗效率的提升。分子影像能够实现肿瘤关键靶点的分子水平定性、定量检测,兼具解剖形态学和功能代谢检测的特点,能够更全面、直观地揭示肿瘤恶性生物学行为,从而为肿瘤精准诊断、指导肿瘤靶向及免疫治疗提供科学依据。借助多功能分子成像探针平台携载治疗药物或选择同时具有成像和治疗作用的放射性核素进行标记,分子影像又能同时实现肿瘤的精准治疗。因此,基于分子影像的精准医学可视化将在基础研究、转化医学以及健康医学领域发挥重要作用,尤其是随着分子影像技术的飞速发展,分子成像早已走出实验室,进入临床转化的关键阶段。其中,放射性核素分子成像凭借独特的优势走到了转化应用的技术前沿,为实现肿瘤精准诊疗带来新的机遇。本文将重点综述目前放射性核素分子影像在临床精准诊断中发挥的作用和价值,以期为致力于肿瘤研究的医务工作者和科研人员提供最新的技术讯息及研发思路。 展开更多
关键词 肿瘤 分子影像 精准医学 临床转化
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Anisotropy of Photocatalytic Properties in Nanostructured Photocatalysts
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作者 Huanchun Wang lina qiao +3 位作者 Haomin Xu Yuanhua Lin Yang Shen Cewen Nan 《Soft Nanoscience Letters》 2016年第2期11-30,共20页
Energy band engineering and the nature of surface/interface of a semiconductor play a significant role in searching high efficiency photocatalysts. Actually, the active facets, morphology controlling, especially the e... Energy band engineering and the nature of surface/interface of a semiconductor play a significant role in searching high efficiency photocatalysts. Actually, the active facets, morphology controlling, especially the exposed facets modulation of photocatalysts during preparation are very desirable. In order to achieve high photocatalytic performance, intrinsic mechanism of such anisotropic properties should be fully considered. In this review, we mainly emphasis on the latest research developments of several extensively investigated photocatalysts and their anisotropic photocatalytic properties, as well as the correlation between effective masses anisotropy and photocatalytic properties. It will be helpful to understand the photocatalytic mechanism and promote rational development of photocatalyst for wide applications. 展开更多
关键词 ANISOTROPY Carriers Effective Mass Photocatalytic Properties
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Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica 被引量:6
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作者 Qiuling Xu Tao Liu +4 位作者 Shuping Chen Yonghui Gao Junying Wang lina qiao Junling Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第3期218-225,共8页
In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic ... In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanfi (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanfi and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. 展开更多
关键词 neural regeneration acupuncture and moxibustion Chronic neuropathic pain electroacupuncture acupuncture analgesia cumulative effect synaptic plasticity HYPOTHALAMUS learning and memory NEUROBIOLOGY grants-supported paper photographs-containing paper neuroregeneration
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The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 region 被引量:3
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作者 Qiulinq Xu Tao Liu +4 位作者 Shuping Chen Yonghui Gao Junying Wang lina qiao Junling Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第18期1378-1385,共8页
In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve ... In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold (paw withdrawal latency) was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptJc cleft width and thinning of the postsynaptJc density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kJnase II expression in the hippocampal CA3 region. 展开更多
关键词 chronic neuropathic pain acupuncture analgesia cumulative effect synaptic plasticity hippocampal CA3 region calcium/calmodulin-dependent protein kinase II NEUROBIOLOGY ELECTROACUPUNCTURE neural regeneration
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Nano-silica-decorated Poly(m-Phenylene Isophthalamide)Separator with Enhanced Mechanical and Electrolyte Wetting Properties for Lithium-Ion Batteries 被引量:2
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作者 Jianjie Wang Biao Yuan +6 位作者 Fusheng Pan lina qiao Jun Guo Cuijia Duan Wei Wu Zan Chen anlei Su 《Transactions of Tianjin University》 EI CAS 2020年第4期256-264,共9页
Heat-resistant poly(m-phenylene isophthalamide)(PMIA)has attracted considerable attention as a novel separator for application in lithium-ion batteries(LIBs);however,its mechanical strength and electrolyte wettability... Heat-resistant poly(m-phenylene isophthalamide)(PMIA)has attracted considerable attention as a novel separator for application in lithium-ion batteries(LIBs);however,its mechanical strength and electrolyte wettability are not ideal.Herein,a nano-silica-decorated poly(m-phenylene isophthalamide)(PMIA@SiO2)separator was fabricated with SiO2 nanoparticles uniformly attached to the pores and pore walls of the PMIA separator.The as-prepared PMIA@SiO2 separator has good mechanical strength(a 16%improvement compared with pristine PMIA)and wettability toward the electrolyte(the contact angle decreases from 34.0°to 23.1°).The PMIA@SiO2 separator also had a high ionic conductivity(0.75 mS/cm)and low interfacial electric resistance(75Ω).The assembled LiCoO2/PMIA@Si O2-liquid electrolyte/Li cell displays good cycle performance with a capacity retention of 88.1%after 50 cycles.Furthermore,the cycling performance and rate capacity rarely changed after high-temperature treatment.Therefore,the nano-silica-decorated PMIA separator is a potential candidate for application in LIBs with high safety. 展开更多
关键词 Li-ion batteries PMIA@SiO2 Separator Mechanical strength Electrolyte wetting
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Double SiC Oxidation Protective Coating on C/C Composites Prepared by Spark Plasma Sintering
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作者 Xianghong Zhang Changhu Yu +4 位作者 lina qiao Beilong Zhao Hao Huang Hongxia Song Xiaochen Sheng 《Journal of Minerals and Materials Characterization and Engineering》 2017年第6期374-384,共11页
Easy oxidation of carbon limits applications of carbon-carbon composites in an oxygen-containing environment. In this study, a two-layer SiC coating was prepared on carbon-carbon composites by a Spark plasma sintering... Easy oxidation of carbon limits applications of carbon-carbon composites in an oxygen-containing environment. In this study, a two-layer SiC coating was prepared on carbon-carbon composites by a Spark plasma sintering technology at 1350°C for 1 min. The coating was mainly composed of β-SiC and Si and well bonded with the substrate. The double SiC coating could effectively protect the C/C composites from oxidation at 1600°C for 120 h, and the corresponding weight loss was only 2.62%. 展开更多
关键词 CARBON-CARBON Composites SPARK Plasma SINTERING ANTI-OXIDATION Coating
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Extraordinary toughening enhancement in nonstoichiometric vanadium carbide
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作者 Chong Peng Hu Tang +11 位作者 Changjian Geng Pengjie Liang Biao Wan Yujiao Ke Yuefeng Wang Peng Jia Wenfeng Peng lina qiao Kenan Li Xiaohong Yuan Yucheng Zhao Mingzhi Wang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第2期176-181,共6页
1.Introduction Fracture toughness is the ability of materials against both the initiation and propagation of cracks[1],which is a crucial mechanical property for safety-critical applications of structural materials.Al... 1.Introduction Fracture toughness is the ability of materials against both the initiation and propagation of cracks[1],which is a crucial mechanical property for safety-critical applications of structural materials.Although the yield strength of ceramics is significantly higher than that of metallic materials,the fracture toughness is severely lower than that of metallic materials due to the strongly directional covalent bonding[1-3].For a long time,how to improve the fracture toughness of ceramics without the deterioration of strength(or hardness)has been one of the most challenging problems in materials science. 展开更多
关键词 TOUGHNESS CARBIDE CERAMICS
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