Controllable NO Release for Catheter Antibacteria from Nitrite Electroreduction over the Cu-MOF

Implant-associated infections caused by biomedical catheters severely threaten patients'health.The use of electrochemical control on NO release from benign nitrite equipped in the catheter can potentially resolve this issue with excellent biocompatibility.Inspired by nitrite reductase,a Cu-BDC(BDC:benzene-1,4-dicarboxylic acid)catalyst with coordinated Cu(Ⅱ)sites was constructed as a heterogeneous electrocatalyst to control nitrite reduction to nitric oxide for catheter antibacteria.The combined results of in situ and ex situ tests unveil the key function of interconversion between Cu(Ⅱ)and Cu(Ⅰ)species in NO_(2)^(-)reduction to NO.After being incorporated into the actual catheter,the Cu-BDC catalyst exhibits high electrocatalytic activity toward NO_(2)^(-)reduction to NO and excellent antibacteria efficacy with a sterilizing rate of 99.9%,paving the way for the development of advanced metal-organic frameworks(MOFs)electrocatalysts for catheter antibacteria.

An overview on CV2/CRMP5 antibody-associated paraneoplastic neurological syndromes

Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome produce multiple antibodies,each targeting a different antigen and causing different symptoms and signs.The CV2/collapsin response mediator protein 5(CRMP5)antibody is a major antibody of this type.It damages the nervous system,which often manifests as limbic encephalitis,chorea,ocular manifestation,cerebellar ataxia,myelopathy,and peripheral neuropathy.Detecting CV2/CRMP5 antibody is crucial for the clinical diagnosis of paraneoplastic neurological syndrome,and anti-tumor and immunological therapies can help to alleviate symptoms and improve prognosis.However,because of the low incidence of this disease,few repo rts and no reviews have been published about it so far.This article intends to review the research on CV2/CRMP5antibody-associated paraneoplastic neurological syndrome and summarize its clinical features to help clinicians comprehensively understand the disease.Additionally,this review discusses the curre nt challenges that this disease poses,and the application prospects of new detection and diagnostic techniques in the field of paraneoplastic neurological syndrom e,including CV2/CRMP5-associated paraneoplastic neurological syndrome,in recent years.

物理化学全线上教学的策略与实践

受新型冠状病毒肺炎疫情影响,学校的教学活动都转到线上进行。本文以天津大学“物理化学”课程为例,介绍了全线上教学的策略、过程设计与实施效果。通过进一步丰富线上教学资源、完善教学手段、实行全过程精细化管理,使得物理化学这门原本不太适合完全线上学习的课程,取得了满意的教学效果。学习过程中,学生的主体地位和教师的主导作用得以完美体现,获得的教学经验对于未来课程教学有很好的借鉴意义。

浸润式课程思政在物理化学实验中的设计与实践

目前,高校课程思政建设深入推进。基于课程思政的理念,本文从优化教学内容、创新教学模式、改革考核评价三个方面进行阐述,深入探讨浸润式课程思政在物理化学实验教学中的设计与实践,从而充分发挥实验课程的育人功能。

亚硝酸钠:亦正亦邪的多面手

亚硝酸钠是肉制品生产中最常使用的一种食品添加剂,本身却有中强毒性。同时又在化工、医药、纺织、机械等行业有着重要的用途。本文以情景剧的形式向读者介绍了亚硝酸钠的制备、性质和用途。

An apodized cubic phase mask used in a wavefront coding system to extend the depth of field

The point spread function(PSF)caused by a wavefront coding system with a cubic phase mask has big side-lobes which leads to bad image restoration.This paper proposes a novel apodized cubic phase mask to suppress the side-lobes of the PSF.Simulated annealing algorithm is used to optimize the cubic and the truncation parameter of the phase mask.The system with the novel phase mask has better performance in the modulation transfer function(MTF)especially in low-and-medium spatial frequency region.The simulation results show that the restored images with the novel phase mask are superior to the one with the classic cubic phase mask in contrast and ringing effect.The experimental results show that the side-lobes of the PSF are suppressed by using the apodized cubic phase mask.

An Uncertainty Evaluation on the ΔK_(th) and ΔK_(IC) of Fine-grained Isotropic Graphite

This paper intensively explores the critical issues related to the quantitative and accurate evaluations of FCG behavior in the early stage,macro fatigue fracture toughness,and the critical crack size for damage tolerance in nuclear graphite.To address these issues,scale-span FCG tests were carried out using two typical specimens,CT and SEM in-situ specimens.These results indicate that the FCG threshold and the effective FCG length have a significant correlation with the modified maximum loop stress theory for a mixed I/II mode.In particular,the effective FCG length(a_(eq))and the applied stress threshold of polycrystalline graphite are important parameters for fatigue damage tolerance design in engineering application.The influencing factors of ΔK_(th,eq) and a_(eq) were discussed in detail using the mixed I/II mode,respectively.In addition,the scattered values of ΔK_(IC) for this graphite can be quantitatively estimated using the Weibull distribution equation.The predicated parameters and experimental results demonstrate a strong correlation.

Treatment of SMA type 1 infants using a single-dose AAV9-mediated gene therapy via intrathecal injection of GC101:An open-label,single-arm study

Spinal muscular atrophy(SMA),a neurodegenerative disorder caused by mutations in survival motor neuron 1(SMN1)resulting in reduced expression of the survival motor neuron(SMN)protein,is inherited in an autosomal recessive manner.SMA type 1 is the most frequent subtype of SMA characterized by onset before 6 months of life,inability to achieve independent sitting,and rapidly progressive respiratory and bulbar deterioration,causing a mortality of>90%before 2 years of age.[1]Currently,there have been two lifelong splice-modifying therapies(nusinersen and risdiplam),and a single-dose gene replacement therapy via intravenous onasemnogene abeparvovec for SMA type 1 patients.

卒中后抑郁的诊断和治疗

卒中后抑郁(post-stroke depression,PSD)严重影响卒中患者的长期预后。PSD的病理生理学机制及危险因素目前尚未完全明确。重要的是,PSD的诊断率低下,相应抗抑郁治疗不及时或不系统,导致卒中复发或死亡风险增高。文章对PSD的筛查、诊断及相关治疗进展进行了综述。

Effects of annealing treatment on tribological behavior of tungsten-doped diamond-like carbon film under lubrication(Part 2):Tribological behavior under MoDTC lubrication

Molybdenum dialkyldithiocarbamate(MoDTC)is widely used as a friction modifier in engine lubricating oil.Under MoDTC lubrication,the friction and wear behaviors of tungsten-doped diamond-like carbon(W-DLC)films annealed at 100-400℃were discussed and evaluated using scanning electron microscopy(SEM),atomic force microscopy(AFM),and Raman spectroscopy.Under(polymerized alpha olefin)PAO+MoDTC lubrication,the coefficient of friction of all samples decreased,but the wear rates of the W-DLC films annealed at 300℃increased significantly.By interacting with zinc dialkyldithiophosphate(ZDDP),the wear rates of W-DLC films annealed at different temperatures declined significantly owing to the formation of dense phosphate tribofilms on the worn surfaces.

Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes

Dear Editor,Recent studies from us and others have deciphered the clinical relevance of a variety of oncohistones1 in different diseases.The H3K27M and H3K36M mutant histones exert dominant-negative effects on methylation levels of histone H3K27 and H3K36 on wildtype histone protein in pediatric brain cancers2–4 and chondroblastoma,5,6 respectively.In contrast to H3K27M and H3K36M that act in trans to cause global reduction of methylation at the respective residues,the H3G34 mutations,including H3G34V/R and H3G34W/L found in pediatric high-grade glioma and giant cell tumor of the bone,affect the H3K36 methylation in cis and alter the H3K36 methylation on the nucleosome containing the H3G34 mutation(s).

Epilepsy control during an epidemic:emerging approaches and a new management framework

Epidemics are a big threat to world health.The ongoing pandemic of corona virus disease 2019(COVID-19)has caused a series of challenges to public health.One such challenge is the management of chronic diseases such as epilepsy during an epidemic event.Studies on this topic are rather limited and the related medical practice is full of uncertainty.Here we review recent development of potential approaches for epilepsy control during an epidemic and propose a new three-level management framework to address these challenges.

Physical Layer Authentication in Wireless Communication Networks:A Survey

Physical layer security(PLS)in wireless communication systems has attracted extensive research attentions in recent years.Unlike cryptography-based methods applied in upper-layer in network,PLS methods are applied in physical layers and can provide information-theoretic security by utilizing the randomness of signals and wireless channels.In this survey,we provide a comprehensive review in the domain of physical layer authentication(PLA)in wireless communication systems,including the concepts,several key techniques of typical PLA architectures as well as future challenges and research trends in more sophisticated communication systems.The survey begins with an overview of the background and basic concepts of PLA,such as the general model of wireless security communication system,typical frameworks of key-based/less PLA systems,and the common attack models.We then discuss the major concerns and key techniques that are applied in PLA systems,where three types of authentication schemes are considered,i.e.,the authentication based on channel information,radio-frequency and identity watermarks.Basic models and representative research results about key approaches and techniques applied to the authentication systems above are subsequently covered.Finally,the associated challenges and potential research trends of PLA in future communication systems are presented at the end of the survey paper.

Sensitive detection of thyroid stimulating hormone by inkjet printed microchip with a double signal amplification strategy

An electrochemical immunosensor for sensitive detection of thyroid stimulating hormone(TSH) has been developed by using an inkjet printed microchip and based on a double signal amplification strategy using magnetic beads(MBs), alkaline phosphatase(ALP) and p-aminophenyl phosphate(pAPP) reaction.Differential pulse voltammetry(DPV), cyclic voltammogram(CV) and amperometric i-t curve(i-t) were employed to characterize the immunosensor. High sensitivity and good selectivity were observed. The detection linear range was from 0.01 μIU/mL to 10 μIU/mL, in which the peak currents increased along with the concentration. The detection limit was 0.005 μIU/mL at S/N = 3. The immunosensor was also applied for TSH detection in human serum with recoveries from 98.0% to 101.8% and relative standard deviations from 1.3% to 3.1%, demonstrating potential value in clinical diagnosis.

The H2BG53D oncohistone directly upregulates ANXA3 transcription and enhances cell migration in pancreatic ductal adenocarcinoma

Dear Editor,Histones are essential proteins in compacting genomic DNA and regulating gene expression.Previous studies on histone H3 oncohistones in pediatric brain cancers1,2 and chondroblastoma3,documented the transcriptomic reprogramming through the alterations of histone modifications.We recently reported the identification of a novel cancer associated mutation,the H2BG53-to-D in pancreatic ductal adenocarcinoma(PDAC)4.We showed that the H2BG53D mutation weakens the interaction between nucleosomal DNA and histone octamer,subsequently enhances transcription in vitro.We further showed that cells expressing the G53D mutant H2B acquired oncogenic phenotypes in our CRISPRCas9 knock-in model.However,the mechanism by which H2BG53D mutation promotes PDAC remains unknown.