Disinfection byproducts(DBPs)represent a ubiquitous source of chemical exposure in disinfected water.While over 700 DBPs have been identified,the drivers of toxicity remain poorly understood.Additionally,ever evolving...Disinfection byproducts(DBPs)represent a ubiquitous source of chemical exposure in disinfected water.While over 700 DBPs have been identified,the drivers of toxicity remain poorly understood.Additionally,ever evolving water treatment practices have led to a continually growing list of DBPs.Advancement of analytical technologies have enabled the identification of new classes of DBPs and the quantification of these chemically diverse sets of DBPs.Here we summarize advances in new workflows for DBP analysis,including sample preparation,chromatographic separation with mass spectrometry(MS)detection,and data processing.To aid in the selection of techniques for future studies,we discuss necessary considerations for each step in the strategy.This review focuses on how each step of a workflow can be optimized to capture diverse classes of DBPs within a single method.Additionally,we highlight new MS-based approaches that can be powerful for identifying novel DBPs of toxicological relevance.We discuss current challenges and provide perspectives on future research directions with respect to studying new DBPs of toxicological relevance.As analytical technologies continue to advance,new strategies will be increasingly used to analyze complex DBPs produced in different treatment processes with the aim to identify potential drivers of toxicity.展开更多
Swimming is excellent exercise and offers many health benefits. However, the ＂chlorine smell＂ in swimming pools may be a turn-off for some people. Although this smell is often thought to be of chlorine, it actually ...Swimming is excellent exercise and offers many health benefits. However, the ＂chlorine smell＂ in swimming pools may be a turn-off for some people. Although this smell is often thought to be of chlorine, it actually comes from volatile compounds that are produced from unintended reactions between disinfectants （e.g., chlorine） and organic matter in the water （Li and Blatchley, 2007; Zwiener et al., 2007; Schmalz et al., 2011; Daiber et al., 2016）. Body fluids, such as sweat and urine, are among the sources of this organic matter that contribute to the formation of disinfection byproducts （DBPs） （Richardson et al., 2007; Arnaud, 2016; Tang et al., 2016）.展开更多
文摘Disinfection byproducts(DBPs)represent a ubiquitous source of chemical exposure in disinfected water.While over 700 DBPs have been identified,the drivers of toxicity remain poorly understood.Additionally,ever evolving water treatment practices have led to a continually growing list of DBPs.Advancement of analytical technologies have enabled the identification of new classes of DBPs and the quantification of these chemically diverse sets of DBPs.Here we summarize advances in new workflows for DBP analysis,including sample preparation,chromatographic separation with mass spectrometry(MS)detection,and data processing.To aid in the selection of techniques for future studies,we discuss necessary considerations for each step in the strategy.This review focuses on how each step of a workflow can be optimized to capture diverse classes of DBPs within a single method.Additionally,we highlight new MS-based approaches that can be powerful for identifying novel DBPs of toxicological relevance.We discuss current challenges and provide perspectives on future research directions with respect to studying new DBPs of toxicological relevance.As analytical technologies continue to advance,new strategies will be increasingly used to analyze complex DBPs produced in different treatment processes with the aim to identify potential drivers of toxicity.
文摘Swimming is excellent exercise and offers many health benefits. However, the ＂chlorine smell＂ in swimming pools may be a turn-off for some people. Although this smell is often thought to be of chlorine, it actually comes from volatile compounds that are produced from unintended reactions between disinfectants （e.g., chlorine） and organic matter in the water （Li and Blatchley, 2007; Zwiener et al., 2007; Schmalz et al., 2011; Daiber et al., 2016）. Body fluids, such as sweat and urine, are among the sources of this organic matter that contribute to the formation of disinfection byproducts （DBPs） （Richardson et al., 2007; Arnaud, 2016; Tang et al., 2016）.
