Tetracycline analogs were designed and synthesized and their bone affinities were tested on hydroxyapatite. The results showed that the carbonyl-amide-enol structure in A ring and phenol-ketone structure in BCD ring m...Tetracycline analogs were designed and synthesized and their bone affinities were tested on hydroxyapatite. The results showed that the carbonyl-amide-enol structure in A ring and phenol-ketone structure in BCD ring may be responsible for tetracycline＇s high bone affinity and either A ring or BCD ring has a planar conformation is essential. 2007 Ling Ling Weng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
Eight of new 5-oxo-[1]benzopyrano[2,3-b]pyridines as the analogues of tetracycline, were designed and synthesized, and their affinity to the hydroxyapatite the inorganic composition of bone were tested.
In this article, using the four-directional core and quaternary carbon branching point, adendritic polyestrone with twelve estrone units was synthesized by convergent strategy. Itsstructure was confirmed by IR and NMR...In this article, using the four-directional core and quaternary carbon branching point, adendritic polyestrone with twelve estrone units was synthesized by convergent strategy. Itsstructure was confirmed by IR and NMR spectra.展开更多
The total synthesis of (+/-)-6-oxa-13 beta-ethyl-3-methoxy-8 alpha-gona-1.3.5(10)-trien-17-one and (+/-)-6-oxa-13 beta-ethyl-2-methoxy-8 alpha-gona-1.3.5(10)-trien-17-one was described.
基金This work was supported by the National Natural Science Foundation of China （No. 30070883）.
文摘Tetracycline analogs were designed and synthesized and their bone affinities were tested on hydroxyapatite. The results showed that the carbonyl-amide-enol structure in A ring and phenol-ketone structure in BCD ring may be responsible for tetracycline＇s high bone affinity and either A ring or BCD ring has a planar conformation is essential. 2007 Ling Ling Weng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
文摘Eight of new 5-oxo-[1]benzopyrano[2,3-b]pyridines as the analogues of tetracycline, were designed and synthesized, and their affinity to the hydroxyapatite the inorganic composition of bone were tested.
文摘In this article, using the four-directional core and quaternary carbon branching point, adendritic polyestrone with twelve estrone units was synthesized by convergent strategy. Itsstructure was confirmed by IR and NMR spectra.
文摘The total synthesis of (+/-)-6-oxa-13 beta-ethyl-3-methoxy-8 alpha-gona-1.3.5(10)-trien-17-one and (+/-)-6-oxa-13 beta-ethyl-2-methoxy-8 alpha-gona-1.3.5(10)-trien-17-one was described.
