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Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
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作者 Nan-Yu Zou Ran liu +18 位作者 Mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min Huang Yi-Li Xu ling liu Yu-Chen Sun Mi Yang Qi Guo Yan Huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo Chang-Jun Li 《Bone Research》 SCIE CAS CSCD 2024年第1期122-136,共15页
Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluse... Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture healing.Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair.Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence.Mechanistically,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular senescence.Depletion of Plxnb2 in SSPCs impaired fracture healing.Administration of GCA-neutralizing antibody enhanced fracture healing in aged mice.Thus,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals. 展开更多
关键词 healing UNION SENESCENCE
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科教融汇、多维贯通的化学化工实验教学新范式建设——以化学化工国家级实验教学示范中心(浙江工业大学)为例
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作者 刘秋平 杨阿三 +3 位作者 蔡金法 刘玲 计伟荣 强根荣 《大学化学》 CAS 2024年第7期1-7,共7页
化学化工国家级实验教学示范中心(浙江工业大学)全面聚焦创新型人才培养,秉承学校“艰苦创业、开拓创新、争创一流”的精神传统,遵循“创新主导、多元融合、寓教于研、协同育人”理念,探索了以“科教融汇、多维贯通”为特色的人才培养模... 化学化工国家级实验教学示范中心(浙江工业大学)全面聚焦创新型人才培养,秉承学校“艰苦创业、开拓创新、争创一流”的精神传统,遵循“创新主导、多元融合、寓教于研、协同育人”理念,探索了以“科教融汇、多维贯通”为特色的人才培养模式,建立了“理工一体、理实一体”化学化工实验教学新体系,打造了“虚实结合、理工融合”化学化工实验教学新平台,创建了“基础与创新并重,化学化工全覆盖”的创新创业教育新机制,形成了具有鲜明工科院校特色的化学化工实验教学新范式,有效提升了学生实践能力与创新精神,取得的成果可为其它同类高校实验室的建设和管理提供借鉴、参考。 展开更多
关键词 国家级实验教学示范中心 化学化工实验教学 实验室建设 人才培养模式
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由苯甲醇合成苯甲酸乙酯综合制备实验的课程思政设计 被引量:3
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作者 刘玲 王海滨 强根荣 《大学化学》 CAS 2024年第2期94-98,共5页
将苯甲酸合成与苯甲酸乙酯制备两个经典实验改造为综合实验,并以改进合成过程实现绿色、高效转化为案例,引导学生通过查阅文献,综合分析合成过程,指出原合成方法存在的问题和不足,提出改进的建议,在此过程中,引导学生将法律法规、实验... 将苯甲酸合成与苯甲酸乙酯制备两个经典实验改造为综合实验,并以改进合成过程实现绿色、高效转化为案例,引导学生通过查阅文献,综合分析合成过程,指出原合成方法存在的问题和不足,提出改进的建议,在此过程中,引导学生将法律法规、实验规范、学科伦理、绿色理念、环保和可持续发展理念等融入实验的设计和实施全过程,使学生在受到基本操作训练的同时得到素质的全面提升。 展开更多
关键词 苯甲醇 苯甲酸 苯甲酸乙酯 有机化学实验 绿色化学 课程思政
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课程思政引领下的分析化学教学改革与实践
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作者 李甜 张莉萍 +3 位作者 刘玲 李瑞芳 毛龙飞 杨晖 《大学化学》 CAS 2024年第6期189-194,共6页
针对分析化学课程传统教学模式的痛点,以课程思政为契机,对课程实施教学改革。阐述了分析化学课程思政建设的总体思路,从重修教学大纲、重构教学内容、改革教学模式、改革课程考核方式等多方位协同进行。通过线上线下混合式教学改革,使... 针对分析化学课程传统教学模式的痛点,以课程思政为契机,对课程实施教学改革。阐述了分析化学课程思政建设的总体思路,从重修教学大纲、重构教学内容、改革教学模式、改革课程考核方式等多方位协同进行。通过线上线下混合式教学改革,使教师的价值引领与学生的深度参与同步进行,实现知识传授、能力培养和价值塑造三位一体的培养目标。 展开更多
关键词 分析化学 课程思政 混合式教学 教学改革
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Design Principles and Mechanistic Understandings of Non-Noble-Metal Bifunctional Electrocatalysts for Zinc-Air Batteries 被引量:1
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作者 Yunnan Gao ling liu +10 位作者 Yi Jiang Dexin Yu Xiaomei Zheng Jiayi Wang Jingwei liu Dan Luo Yongguang Zhang Zhenjia Shi Xin Wang Ya‑Ping Deng Zhongwei Chen 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第9期13-48,共36页
Zinc-air batteries(ZABs)are promising energy storage systems because of high theoretical energy density,safety,low cost,and abundance of zinc.However,the slow multi-step reaction of oxygen and heavy reliance on noble-... Zinc-air batteries(ZABs)are promising energy storage systems because of high theoretical energy density,safety,low cost,and abundance of zinc.However,the slow multi-step reaction of oxygen and heavy reliance on noble-metal catalysts hinder the practical applications of ZABs.Therefore,feasible and advanced non-noble-metal elec-trocatalysts for air cathodes need to be identified to promote the oxygen catalytic reaction.In this review,we initially introduced the advancement of ZABs in the past two decades and provided an overview of key developments in this field.Then,we discussed the work-ing mechanism and the design of bifunctional electrocatalysts from the perspective of morphology design,crystal structure tuning,interface strategy,and atomic engineering.We also included theoretical studies,machine learning,and advanced characterization technologies to provide a comprehensive understanding of the structure-performance relationship of electrocatalysts and the reaction pathways of the oxygen redox reactions.Finally,we discussed the challenges and prospects related to designing advanced non-noble-metal bifunctional electrocatalysts for ZABs. 展开更多
关键词 Zinc-air batteries Bifunctional electrocatalysts Design principles Mechanistic understandings
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铁死亡抑制因子KIF20A对食管癌细胞生物学行为及铁死亡的影响
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作者 热则耶·麦麦提祖农 李秀娟 +1 位作者 刘玲 李卉 《昆明医科大学学报》 CAS 2024年第2期49-56,共8页
目的探讨驱动蛋白家族成员20A(KIF20A)在食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中的表达及对Eca109细胞生物学行为和铁死亡的影响。方法通过生物信息学分析预测KIF20A在ESCC中的表达。构建KIF20A敲低/过表达Eca109... 目的探讨驱动蛋白家族成员20A(KIF20A)在食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中的表达及对Eca109细胞生物学行为和铁死亡的影响。方法通过生物信息学分析预测KIF20A在ESCC中的表达。构建KIF20A敲低/过表达Eca109细胞系,实验分组:对照组,KIF20A敲低组,KIF20A过表达组。通过CCK-8法,Transwell侵袭实验,细胞划痕实验检测KIF20A对Eca109细胞增殖,迁移能力的影响。采用RAS选择性致死化合物3(RSL3)诱导建立铁死亡应激模型,检测谷胱甘肽(glutathione,GSH),丙二醛(malondialdehyde,MDA)含量。结果和对照组比较,KIF20A敲低组细胞增殖活力降低(P<0.05),KIF20A过表达组细胞增殖活力增加(P<0.05)。与对照组比较,KIF20A敲低组细胞侵袭及迁移能力降低(P<0.05),KIF20过表达组细胞侵袭及迁移能力增加(P<0.05)。RSL3诱导处理后,KIF20A敲低组细胞裂解液中GSH含量低于对照组(P<0.05),MDA含量高于对照组(P<0.05);KIF20A过表达组细胞结果与之相反。结论KIF20A在ESCC中高表达,其在Eca109细胞中发挥着促进增殖、侵袭、迁移及抑制铁死亡的作用。 展开更多
关键词 铁死亡 驱动蛋白家族成员20A 食管鳞状细胞癌 RAS选择性致死化合物3
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Pd^(0)-O v-Ce^(3+) Interfacial Sites with Charge Redistribution for Enhanced Hydrogenation of Methyl Oleate to Methyl Stearate
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作者 Zhaohui Meng Ying Liao +6 位作者 ling liu Yaqian Li Hao Yan Xiang Feng Xiaobo Chen Yibin liu Chaohe Yang 《Transactions of Tianjin University》 EI CAS 2024年第4期359-368,共10页
Improving the efficiency of metal/reducible metal oxide interfacial sites for hydrogenation reactions of unsaturated groups(e.g.,C=C and C=O)is a promising yet challenging endeavor.In our study,we developed a Pd/CeO_(... Improving the efficiency of metal/reducible metal oxide interfacial sites for hydrogenation reactions of unsaturated groups(e.g.,C=C and C=O)is a promising yet challenging endeavor.In our study,we developed a Pd/CeO_(2) catalyst by enhancing the oxygen vacancy(O V)concentration in CeO_(2) through high-temperature treatment.This process led to the formation of an interface structure ideal for supporting the hydrogenation of methyl oleate to methyl stearate.Specifi cally,metal Pd^(0) atoms bonded to the O V in defective CeO_(2) formed Pd^(0)-O v-Ce^(3+)interfacial sites,enabling strong electron transfer from CeO_(2) to Pd.The interfacial sites exhibit a synergistic adsorption eff ect on the reaction substrate.Pd^(0) sites promote the adsorption and activation of C=C bonds,while O V preferably adsorbs C=O bonds,mitigating competition with C=C bonds for Pd^(0) adsorption sites.This synergy ensures rapid C=C bond activation and accelerates the attack of active H*species on the semi-hydrogenated intermediate.As a result,our Pd/CeO_(2)-500 catalyst,enriched with Pd^(0)-O v-Ce^(3+)interfacial sites,dem-onstrated excellent hydrogenation activity at just 30℃.The catalyst achieved a Cis-C18:1 conversion rate of 99.8% and a methyl stearate formation rate of 5.7 mol/(h·g metal).This work revealed the interfacial sites for enhanced hydrogenation reactions and provided ideas for designing highly active hydrogenation catalysts. 展开更多
关键词 HYDROGENATION Interfacial sites Oxygen vacancy C=C bond
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Electron capture and excitation in intermediate-energy He^(2+)–H(1s,2s)collisions
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作者 刘亚东 贾聪聪 +5 位作者 马茗萱 高翔 刘玲 吴勇 陈向军 王建国 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第8期72-79,共8页
The semiclassical non-perturbative atomic orbital close-coupling approach has been employed to study the electron capture and excitation processes in He^(2+)-H(1s)and He^(2+)-H(2s)collision systems.In order to ensure ... The semiclassical non-perturbative atomic orbital close-coupling approach has been employed to study the electron capture and excitation processes in He^(2+)-H(1s)and He^(2+)-H(2s)collision systems.In order to ensure the accuracy of our calculated cross sections,a large number of high excited states and pseudostates are included in the expansion basis sets which are centered on the target and projectile,respectively.The total and partial charge transfer and excitation cross sections are obtained for a wide-energy domain ranging from 1 keV/amu to 200 keV/amu.The present calculations are also compared with the results from other theoretical methods.These cross section data are useful for the investigation of astrophysics and laboratory plasma. 展开更多
关键词 atomic orbital close-coupling(AOCC)method inelastic collision processes electron capture and excitation
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Effect of drying methods on perovskite films and solar cells
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作者 ling liu Chuantian Zuo +3 位作者 Guang-Xing Liang Hua Dong Jingjing Chang Liming Ding 《Journal of Semiconductors》 EI CAS CSCD 2024年第1期1-5,共5页
The high efficiency,solution processibility,and flexibility of perovskite solar cells make them promising candidates for the photovoltaic industry[1−8].The deposition method is one of the most critical factors that af... The high efficiency,solution processibility,and flexibility of perovskite solar cells make them promising candidates for the photovoltaic industry[1−8].The deposition method is one of the most critical factors that affect the performance of perovskite films.Various deposition methods have been developed to make perovskite films,including spin-coating,slotdie coating. 展开更多
关键词 PEROVSKITE FILMS CRITICAL
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垂直再生——经开区天空之境产业广场
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作者 刘凌 吴钢 +2 位作者 王瑾 秦元高 徐春艳 《城市设计》 2024年第3期52-55,共4页
经开区天空之境产业广场项目是北京经济技术开发区内一项城市更新的典范工程。原址为废弃的达涅利冶金设备生产基地,该项目通过回购和拆除重建,转型为聚焦生物医药产业的绿色智能摩天工厂。项目不仅提升了土地效能,促进了产业升级,还成... 经开区天空之境产业广场项目是北京经济技术开发区内一项城市更新的典范工程。原址为废弃的达涅利冶金设备生产基地,该项目通过回购和拆除重建,转型为聚焦生物医药产业的绿色智能摩天工厂。项目不仅提升了土地效能,促进了产业升级,还成功引入了上市企业义翘神州,预计到2025年将显著带动周围区域经济增长。项目采用创新的融资模式,贯彻了集约节约、产业集群、专业空间载体及绿色共享园区的理念,为城市更新提供了新思路和实践案例。 展开更多
关键词 城市更新 产业升级 绿色建筑 垂直再生
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Solution to the Horizontal Crossing Problem of Transportation System at Key Points in Open-Pit Mines
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作者 Tao DONG ling liu 《Asian Agricultural Research》 2024年第7期36-38,47,共4页
In order to reduce the horizontal crossing transportation problems between coal trucks and stripping trucks,large and small vehicles,and transport trucks and belt conveyors at key points of open pit mine in production... In order to reduce the horizontal crossing transportation problems between coal trucks and stripping trucks,large and small vehicles,and transport trucks and belt conveyors at key points of open pit mine in production,the separate transportation mode of underpass bridge and overpass steel trestle is proposed to optimize the open pit development transportation system,so as to solve the practical problems that the horizontal cross of transport vehicles causes vehicle blockage,affects production schedule and production safety.The results show that the horizontal crossing road can be changed into a separate type of overpass steel trestle,which can realize the classified transportation of large and small vehicles,reduce the traffic density,make vehicles with different functions go their own way,eliminate the hidden danger of traffic accidents,and improve the production efficiency. 展开更多
关键词 Open-pit mines Cross-transport Underpass bridge Overpass steel trestle Production efficiency
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Feasibility of Synchronously Straightening Working Line of Adjacent Open-cast Mines
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作者 ling liu Tao DONG 《Asian Agricultural Research》 2024年第7期28-32,共5页
Taking Heidaigou Open-cast Mine and Haerwusu Open-cast Mine in Zhungeer mining area as the research objects,this paper deeply analyzes the current mining status of the two mines.Based on the existing working line leng... Taking Heidaigou Open-cast Mine and Haerwusu Open-cast Mine in Zhungeer mining area as the research objects,this paper deeply analyzes the current mining status of the two mines.Based on the existing working line length,mining technology,transportation system,equipment configuration,transportation access and many other factors,it systematically discusses the feasibility of straightening the working line of adjacent open-cast mines.Through in-depth theoretical analysis,it establishes the mathematical model of impact indicators and cost calculation,and it is concluded that the work line straightening can be technically achieved.However,from the perspective of economic benefits,straightening the working line does not show obvious advantages. 展开更多
关键词 Adjacent open-cast mines Tracing the mining Working line straightening Advancing direction
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Research Progress on the Application of Cluster Nursing Mode in ECMO-Assisted Patients
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作者 ling liu Sheilla Magbanua Trajera 《Journal of Clinical and Nursing Research》 2024年第3期72-75,共4页
Cluster care,also known as cluster therapy,cluster intervention,or bundled therapy,is a series of evidence-based supportive joint care measures developed to improve the quality of care for specific patients or nursing... Cluster care,also known as cluster therapy,cluster intervention,or bundled therapy,is a series of evidence-based supportive joint care measures developed to improve the quality of care for specific patients or nursing issues.It is highly reliable and can effectively improve patient prognosis.This article summarized the application of cluster nursing care in extracorporeal membrane oxygenation(ECMO)-assisted patients and the problems faced to provide a reference for evidence-based decision-making in clinical practice. 展开更多
关键词 Bundled care ECMO Critical and severe
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Blood exosomal micro ribonucleic acid profiling reveals the complexity of hepatocellular carcinoma and identifies potential biomarkers for differential diagnosis 被引量:6
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作者 Lang-Qing Sheng Jia-Rong Li +15 位作者 Hao Qin ling liu Da-Dong Zhang Qi Zhang Meng-Li Huang Xiao-Li Li Xiao-Ya Xu Yang-Nian Wei Zi-Shuo Chen Hui Luo Ji-Yang Zhang Cheng-Hui Zhou Hao Chen Ze-Guo Chen Fu-Gen Li Nian-Feng Li 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2020年第10期1195-1208,共14页
BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths worldwide,but there is a shortage of effective biomarkers for its diagnosis.AIM To explore blood exosomal micro ribonucleic... BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths worldwide,but there is a shortage of effective biomarkers for its diagnosis.AIM To explore blood exosomal micro ribonucleic acids(miRNAs)as potential biomarkers for HCC diagnosis.RESULTS The principal component analysis suggested that daily alcohol consumption could alter the blood exosomal miRNA profiles of hepatitis B virus positive non-HCC patients through miR-3168 and miR-223-3p.The miRNA profiles also revealed the tumor stages of HCC patients.High expression of miR-455-5p and miR-30c-5p,which significantly correlated with better overall survival in tumor tissues,could also be detected in blood exosomes.Two pairs of miRNAs(miR-584-5p/miR-106-3p and miR-628-3p/miR-941)showed a 94.1%sensitivity and 68.4%specificity to differentiate HCC patients from non-HCC patients.The specificity of the combination was substantially influenced by alcohol consumption habits.CONCLUSION This study suggested that blood exosomal miRNAs can be used as new noninvasive diagnostic tools for HCC.However,their accuracy could be affected by tumor stage and alcohol consumption habits. 展开更多
关键词 Blood exosomal micro ribonucleic acids Biomarker Differential diagnosis Alcohol consumption habit Hepatocellular carcinoma BIOINFORMATICS
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Finite-State Markov Wireless Channel Modeling for Railway Tunnel Environments 被引量:3
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作者 Cuiran Li ling liu Jianli Xie 《China Communications》 SCIE CSCD 2020年第2期30-39,共10页
In recent years,high-speed railways(HSRs)have developed rapidly with a high transportation capacity and high comfort level.A tunnel is a complex high-speed rail terrain environment.It is very important to establish an... In recent years,high-speed railways(HSRs)have developed rapidly with a high transportation capacity and high comfort level.A tunnel is a complex high-speed rail terrain environment.It is very important to establish an accurate channel propagation model for a railway tunnel environment to improve the safety of HSR operation.In this paper,a method for finite-state Markov chain(FSMC)channel modeling with least squares fitting based on non-uniform interval division is proposed.First,a path loss model is obtained according to measured data.The communication distance between the transmitter and receiver in the tunnel is non-uniformly divided into several large non-overlapping intervals based on the path loss model.Then,the Lloyd-Max quantization method is used to determine the threshold of the signal-to-noise ratio(SNR)and the channel state quantization value and obtain the FSMC state transition probability matrix.Simulation experiments show that the proposed wireless channel model has a low mean square error(MSE)and can accurately predict the received signal power in a railway tunnel environment. 展开更多
关键词 railway tunnel FSMC channel model SNR path loss
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China requires region-specific manure treatment and recycling technologies 被引量:3
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作者 Zhaohai Bai Xuan Wang +5 位作者 Xiaofei Wu Weishuai Wang ling liu Xiaohang Zhang Xiangwen Fan Lin Ma 《Circular Agricultural Systems》 2021年第1期1-8,共8页
Heterogenous distribution of crops,feed and livestock across China has halted the circulation of nutrients within the agricultural system and is responsible for massive nutrient losses[1,2].Generated livestock manure ... Heterogenous distribution of crops,feed and livestock across China has halted the circulation of nutrients within the agricultural system and is responsible for massive nutrient losses[1,2].Generated livestock manure exceeded optimal crop requirements in 30%and 50%of over 2300 studied counties when there was improved recycling of nitrogen(N)and phosphorus(P)in the food chain,repectively[2].Most of these counties are located in southern and coastal areas,whereas there is a deficit of livestock manure in northern and western China.Such heterogenous distribution of crop-livestock production led to 4.0 Tg manure N and 0.9 Tg manure P[2],which are economically impossible to recycle and will end up in the surrounding environment.In addition,about 40%of feed protein consumed by domestic livestock production relied on importation,putting China’s livestock production supply at high risk in the post pandemic world[3].Hence,China is facing the twin issues of too many manure nutrients but too little feed nutrients simultaneously. 展开更多
关键词 MANURE crops LIVESTOCK
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Debye-screening effect on electron-impact excitation of helium-like Al^(11+)and Fe^(24+)ions
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作者 Yu-Long Ma ling liu +5 位作者 Lu-You Xie Yong Wu Deng-Hong Zhang Chen-Zhong Dong Yi-Zhi Qu Jian-Guo Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第4期299-304,共6页
Debye-screening effects on the electron-impact excitation(EIE)processes for the dipole-allowed transition 1 s_(2)^(1)S→1 s2 p^(1)P in He-like Al^(11+)and Fe^(24+)ions are investigated using the fully relativistic dis... Debye-screening effects on the electron-impact excitation(EIE)processes for the dipole-allowed transition 1 s_(2)^(1)S→1 s2 p^(1)P in He-like Al^(11+)and Fe^(24+)ions are investigated using the fully relativistic distorted-wave methods with the Debye-Huckel(DH)model potential.Debye-screening effects on the continuum-bound(CB)interaction and target ion are discussed,both of which result in reduction of EIE cross sections.This reduction due to screening on the CB interaction is dominant.The non-spherical and spherical DH potentials are adopted for considering the screening effect on the CB interaction.It is found that the spherical DH potential could significantly overestimate the influence of plasma screening on EIE cross sections for multielectron He-like ions. 展开更多
关键词 Debye plasmas electron-impact excitation Debye-Hückel model potential He-like Al^(11+)and Fe^(24+)ions
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Electron excitation processes in low energy collisions of hydrogen-helium atoms
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作者 Kun Wang Chuan Dong +4 位作者 Yi-Zhi Qu ling liu Yong Wu Xu-Hai Hong Robert J.Buenker 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第12期213-218,共6页
The electron excitation processes of H(1s)+He(1s^(2))→H(2s/2p)+He(1s^(2))are studied in impact energy range of 20-2000 e V/u by using the quantum-mechanical molecular orbital close-coupling(QMOCC)method.Total and sta... The electron excitation processes of H(1s)+He(1s^(2))→H(2s/2p)+He(1s^(2))are studied in impact energy range of 20-2000 e V/u by using the quantum-mechanical molecular orbital close-coupling(QMOCC)method.Total and state-selective cross sections have been obtained and compared with the available theoretical and experimental results.The results agree well with available measurements in the overlapping energy regions overall.The comparison of our results with other theoretical calculations further demonstrates the importance of considering a sufficient number of channels.The datasets presented in this paper,including the excitation cross sections,are openly available at https://www.doi.org/10.57760/sciencedb.j00113.00083. 展开更多
关键词 electron excitation processes low energy collision quantum-mechanical molecular orbital close-coupling method cross section
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基于数据挖掘的《医案类聚》痿证用药规律分析 被引量:1
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作者 刘灵 高龙霞 +2 位作者 李萌 李辰 赵汉青 《数理医药学杂志》 CAS 2023年第2期88-94,共7页
目的 分析挖掘《医案类聚》中治疗痿证医案中的用药规律,为痿证的临床治疗提供参考。方法 搜集整理《医案类聚》中古代医家的医案,根据纳入排除标准提取处方药物,进行规范化处理,应用古今医案云平台软件(V2.3.5)对处方数据进行频次统计... 目的 分析挖掘《医案类聚》中治疗痿证医案中的用药规律,为痿证的临床治疗提供参考。方法 搜集整理《医案类聚》中古代医家的医案,根据纳入排除标准提取处方药物,进行规范化处理,应用古今医案云平台软件(V2.3.5)对处方数据进行频次统计、聚类分析、关联分析、复杂网络等分析,得到古代医家治疗痿证的用药规律。结果 经过筛选,共涉及医家38人,纳入医案157案,共166诊次,总用药频次1 596次。常用中药味多甘苦,主要归于肾、肝经,高频药物为当归、牛膝、茯苓,常用药对有当归-牛膝、虎胫骨-牛膝等,核心方药组成以虎潜丸为基础加减。结论 《医案类聚》中各医家治疗痿证的常用药物以补肝肾、强筋骨为主,清利湿热、调畅气机为辅,治疗以补益为主,以肝肾为本,辅以清热坚阴。 展开更多
关键词 痿证 医案类聚 古今医案云平台 数据挖掘
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4‑Terminal Inorganic Perovskite/Organic Tandem Solar Cells Offer 22%Efficiency 被引量:2
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作者 ling liu Hanrui Xiao +10 位作者 Ke Jin Zuo Xiao Xiaoyan Du Keyou Yan Feng Hao Qinye Bao Chenyi Yi Fangyang liu Wentao Wang Chuantian Zuo Liming Ding 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第2期172-181,共10页
After fast developing of single-junction perovskite solar cells and organic solar cells in the past 10 years,it is becoming harder and harder to improve their power conversion efficiencies.Tandem solar cells are recei... After fast developing of single-junction perovskite solar cells and organic solar cells in the past 10 years,it is becoming harder and harder to improve their power conversion efficiencies.Tandem solar cells are receiving more and more attention because they have much higher theoretical efficiency than single-junction solar cells.Good device performance has been achieved for perovskite/silicon and perovskite/perovskite tandem solar cells,including 2-terminal and 4-terminal structures.However,very few studies have been done about 4-terminal inorganic perovskite/organic tandem solar cells.In this work,semi-transparent inorganic perovskite solar cells and organic solar cells are used to fabricate 4-terminal inorganic perovskite/organic tandem solar cells,achieving a power conversion efficiency of 21.25%for the tandem cells with spin-coated perovskite layer.By using drop-coating instead of spin-coating to make the inorganic perovskite films,4-terminal tandem cells with an efficiency of 22.34%are made.The efficiency is higher than the reported 2-terminal and 4-terminal inorganic perovskite/organic tandem solar cells.In addition,equivalent 2-terminal tandem solar cells were fabricated by connecting the sub-cells in series.The stability of organic solar cells under continuous illumination is improved by using semi-transparent perovskite solar cells as filter. 展开更多
关键词 4-Terminal tandem solar cells Inorganic perovskite solar cells Organic solar cells SEMITRANSPARENT Drop-coating
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