The emergence of new engineering disciplines has resulted in the growing trend of cross-discipline,and the enhancement of students’technical application ability has become the main teaching objective of engineering d...The emergence of new engineering disciplines has resulted in the growing trend of cross-discipline,and the enhancement of students’technical application ability has become the main teaching objective of engineering disciplines.For this reason,the Internet of Things(IoT)engineering program should be actively reformed,providing students with sufficient opportunities to improve their practical skills.This paper identifies the challenges within practical teaching of IoT engineering,delves into effective strategies for practical IoT teaching within the context of emerging engineering disciplines,and presents practical teaching experiences from the School of Information Engineering at Hainan University of Science and Technology as a case study.The aim is to offer guidance and insights to educators in this field.展开更多
On the basis of expounding the corrosion mechanism of the stator hollow copper conductor in the water-cooling generator, methods of preventing corrosion of the stator hollow copper conductor in the wa-ter-cooling gene...On the basis of expounding the corrosion mechanism of the stator hollow copper conductor in the water-cooling generator, methods of preventing corrosion of the stator hollow copper conductor in the wa-ter-cooling generator through adjusting water quality of its cooling water have been proposed. For internal water cooling systems which are airtight, the corrosion of the hollow copper conductor can be prevented through keeping foreign oxygen and carbon dioxide from entering the system, and the amount of oxygen in the internal water can be lowered by blowing high purity nitrogen. For systems not airtight, the corrosion of the hollow copper conductor can be inhibited through lowering the amount of oxygen to some extent by sealing and increasing pH value by processing part of cooling water with bypass small flow sodium-type mix-bed.展开更多
Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In ...Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In an earlier phase I study, a novel form of recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) that is currently in clinical development for the treatment of hematologic malignancies, i.e., circularly permuted TRAIL(CPT), was well tolerated at a dose of 2.5 mg/kg per day and showed promising preliminary activity in patients with RRMM. This phase II, open-label, multicenter study further investigated the eicacy and safety of 2.5-mg/kg per day CPT as single-agent therapy for patients with RRMM.Methods: Patients with RRMM were treated once daily with CPT(2.5 mg/kg, intravenously) for 14 consecutive days for each 21-day cycle. Clinical response and toxicity were assessed after each treatment cycle.Results: Twenty-seven patients received CPT. Using the European Group for Blood and Marrow Transplantation criteria, we calculated the overall response rate of 33.3% with 1 near-complete response(n CR) and 8 partial responses(PRs). The clinical beneit rate(48.1%) included 1 nCR, 8 PRs, and 4 minimal responses. The most common treatmentrelated adverse events(TRAEs) were fever, aspartate aminotransferase elevation, alanine aminotransferase elevation, leucopenia, rash, neutropenia, and thrombocytopenia. We graded toxicity using the Common Toxicity Criteria for Adverse Events, version 3.0, and determined that 37.0% of patients had at least 1 grade 3–4 TRAE.Conclusions: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted.展开更多
The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental horm...The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental hormone pollution,such as reducing the use of goods and pesticide and the study of new substitutes and degradation technology are advanced.展开更多
AIM To determine if packed red blood cell transfusions contribute to the development of parenteral nutrition associated liver disease. METHODS A retrospective chart review of 49 premature infants on parenteral nutriti...AIM To determine if packed red blood cell transfusions contribute to the development of parenteral nutrition associated liver disease. METHODS A retrospective chart review of 49 premature infants on parenteral nutrition for > 30 d who received packed red blood cell(PRBC) transfusions was performed. Parenteral nutrition associated liver disease was primarily defined by direct bilirubin(db) > 2.0 mg/dL. A high transfusion cohort was defined as receiving > 75 mL packed red blood cells(the median value). KaplanMeier plots estimated the median volume of packedred blood cells received in order to develop parenteral nutrition associated liver disease.RESULTS Parenteral nutritional associated liver disease(PNALD) was noted in 21(43%) infants based on db. Among the 27 high transfusion infants, PNALD was present in 17(64%) based on elevated direct bilirubin which was significantly greater than the low transfusion recipients. About 50% of the infants, who were transfused 101-125 mL packed red blood cells, developed PNALD based on elevation of direct bilirubin. All infants who were transfused more than 200 mL of packed red blood cells developed PNALD. Similar results were seen when using elevation of aspartate transaminase or alanine transaminase to define PNALD.CONCLUSION In this retrospective, pilot study there was a statistically significant correlation between the volume of PRBC transfusions received by premature infants and the development of PNALD.展开更多
Molecular dynamics simulations are used to study the boundary lubrication behaviors of squalane lubricant between two iron wall structures during shearing at different pressures and temperatures.Boundary lubrication m...Molecular dynamics simulations are used to study the boundary lubrication behaviors of squalane lubricant between two iron wall structures during shearing at different pressures and temperatures.Boundary lubrication models with a smooth iron wall and a nanostructured iron wall,respectively,are constructed,and the density distribution of the lubricating film and the velocity distribution in the shearing process are analyzed.The mechanical response of the solid wall is output,and the friction coefficient is calculated.A tribological test is performed with a UMT-2 tribometer under sliding conditions to evaluate the reliability of the simulation method.The results show that the surface nanostructure has a significant effect on the film thickness and delamination of the lubricating film but little effect on the velocity distribution of the lubricating film.The nano strip groove helps to reduce the friction coefficient of the boundary lubrication system.展开更多
As a kind of biopolymer,hydrolysates of fish swim bladder,safer than those of land mammals,are widely used in food,cosmetics as well as pharmaceutical and biomedical fields for their biocompatibility,biodegradability,...As a kind of biopolymer,hydrolysates of fish swim bladder,safer than those of land mammals,are widely used in food,cosmetics as well as pharmaceutical and biomedical fields for their biocompatibility,biodegradability,and weak antigenicity.To enhance hydrolysate production,in this paper,the papain and alcalase hydrolysis processes of larimichthys polyactis swim bladder were optimized with orthogonal experiments.With 89.5%hydrolysate yield,the optimal processing conditions for alcalase were solid-liquid ratio of 1:30,enzyme concentration of 0.7%,and extraction time of 6 h.As for papain,under the optimal processing conditions:solid-liquid ratio of 1:20,enzyme concentration of 0.5%,and extraction time of 8 h,the hydrolysate yield was 65.1%.To obtain higher hydrolysate yields,the ultrasonic pretreatments were implemented before the optimal enzyme hydrolysis processes.With ultrasonic waves of 100 W for 50 min,the hydrolysate yields were increased 2.1%(alcalase)and 4.5%(papain),respectively.The Fourier Transform Infrared(FTIR)spectroscopic analysis revealed that the hydrolysates extracted by papain exist in triple-helical forms.The Ultra-Violet(UV)absorption spectra indicated that the aromatic amino acids in the hydrolysates had strong absorptions in the wavelength range of 240 nm–300 nm.The results of this research demonstrate that the alcalase hydrolysates have better solubility in water and the solution is more stable under ambient temperature.However,the hydrolysates extracted by papain have a gel property and are insoluble in weak acid at room temperature,which is more suitable for applications in feedstock of biomedical.展开更多
Social trust network(STN)and minimum cost consensus(MCC)models have been widely used to address consensus issues in multi-attribute group decision-making(MAGDM)problems with limited resources.However,most researchers ...Social trust network(STN)and minimum cost consensus(MCC)models have been widely used to address consensus issues in multi-attribute group decision-making(MAGDM)problems with limited resources.However,most researchers have overlooked the decision maker‘(DMs)’confidence levels(CLs)and adjustment willingness implicit in their evaluations.To address these problems,this paper explores a confidence-based MCC model that considers DMs’adjustment willingness in the STN.The proposed model includes several modifications to the traditional trust propagation and consensus optimization models.Firstly,the improved method for measuring CLs of DMs and the confidence-based normalization approach are defined,respectively.Secondly,the bounded trust propagation operator is proposed,which considers the credibility of mediators to complete the STN.Thirdly,the identification rules based on the consensus index and CL are defined,and the MCC model with personalized cost functions and acceptable adjustment thresholds is built to automatically generate adjustment values for non-consensus DMs.Finally,a model to identify the non-cooperative behavior at the element level is established and the hybrid MCC model with persuasion strategies is provided.Finally,a case study is processed to verify the applicability of the proposed model,and comparison and sensitivity analysis are conducted to highlight its benefits.展开更多
文摘The emergence of new engineering disciplines has resulted in the growing trend of cross-discipline,and the enhancement of students’technical application ability has become the main teaching objective of engineering disciplines.For this reason,the Internet of Things(IoT)engineering program should be actively reformed,providing students with sufficient opportunities to improve their practical skills.This paper identifies the challenges within practical teaching of IoT engineering,delves into effective strategies for practical IoT teaching within the context of emerging engineering disciplines,and presents practical teaching experiences from the School of Information Engineering at Hainan University of Science and Technology as a case study.The aim is to offer guidance and insights to educators in this field.
文摘On the basis of expounding the corrosion mechanism of the stator hollow copper conductor in the water-cooling generator, methods of preventing corrosion of the stator hollow copper conductor in the wa-ter-cooling generator through adjusting water quality of its cooling water have been proposed. For internal water cooling systems which are airtight, the corrosion of the hollow copper conductor can be prevented through keeping foreign oxygen and carbon dioxide from entering the system, and the amount of oxygen in the internal water can be lowered by blowing high purity nitrogen. For systems not airtight, the corrosion of the hollow copper conductor can be inhibited through lowering the amount of oxygen to some extent by sealing and increasing pH value by processing part of cooling water with bypass small flow sodium-type mix-bed.
文摘Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In an earlier phase I study, a novel form of recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) that is currently in clinical development for the treatment of hematologic malignancies, i.e., circularly permuted TRAIL(CPT), was well tolerated at a dose of 2.5 mg/kg per day and showed promising preliminary activity in patients with RRMM. This phase II, open-label, multicenter study further investigated the eicacy and safety of 2.5-mg/kg per day CPT as single-agent therapy for patients with RRMM.Methods: Patients with RRMM were treated once daily with CPT(2.5 mg/kg, intravenously) for 14 consecutive days for each 21-day cycle. Clinical response and toxicity were assessed after each treatment cycle.Results: Twenty-seven patients received CPT. Using the European Group for Blood and Marrow Transplantation criteria, we calculated the overall response rate of 33.3% with 1 near-complete response(n CR) and 8 partial responses(PRs). The clinical beneit rate(48.1%) included 1 nCR, 8 PRs, and 4 minimal responses. The most common treatmentrelated adverse events(TRAEs) were fever, aspartate aminotransferase elevation, alanine aminotransferase elevation, leucopenia, rash, neutropenia, and thrombocytopenia. We graded toxicity using the Common Toxicity Criteria for Adverse Events, version 3.0, and determined that 37.0% of patients had at least 1 grade 3–4 TRAE.Conclusions: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted.
文摘The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental hormone pollution,such as reducing the use of goods and pesticide and the study of new substitutes and degradation technology are advanced.
文摘AIM To determine if packed red blood cell transfusions contribute to the development of parenteral nutrition associated liver disease. METHODS A retrospective chart review of 49 premature infants on parenteral nutrition for > 30 d who received packed red blood cell(PRBC) transfusions was performed. Parenteral nutrition associated liver disease was primarily defined by direct bilirubin(db) > 2.0 mg/dL. A high transfusion cohort was defined as receiving > 75 mL packed red blood cells(the median value). KaplanMeier plots estimated the median volume of packedred blood cells received in order to develop parenteral nutrition associated liver disease.RESULTS Parenteral nutritional associated liver disease(PNALD) was noted in 21(43%) infants based on db. Among the 27 high transfusion infants, PNALD was present in 17(64%) based on elevated direct bilirubin which was significantly greater than the low transfusion recipients. About 50% of the infants, who were transfused 101-125 mL packed red blood cells, developed PNALD based on elevation of direct bilirubin. All infants who were transfused more than 200 mL of packed red blood cells developed PNALD. Similar results were seen when using elevation of aspartate transaminase or alanine transaminase to define PNALD.CONCLUSION In this retrospective, pilot study there was a statistically significant correlation between the volume of PRBC transfusions received by premature infants and the development of PNALD.
基金This work was supported by the National Natural Science Foundation of China(Nos.51875105 and 51875106)the Jinjiang Science and Education Project of Fuzhou University(No.2019-JJFDKY-54)the Industry-Academy Cooperation Project of Fujian Province(No.2020H6025).
文摘Molecular dynamics simulations are used to study the boundary lubrication behaviors of squalane lubricant between two iron wall structures during shearing at different pressures and temperatures.Boundary lubrication models with a smooth iron wall and a nanostructured iron wall,respectively,are constructed,and the density distribution of the lubricating film and the velocity distribution in the shearing process are analyzed.The mechanical response of the solid wall is output,and the friction coefficient is calculated.A tribological test is performed with a UMT-2 tribometer under sliding conditions to evaluate the reliability of the simulation method.The results show that the surface nanostructure has a significant effect on the film thickness and delamination of the lubricating film but little effect on the velocity distribution of the lubricating film.The nano strip groove helps to reduce the friction coefficient of the boundary lubrication system.
基金This research was funded by the Fundamental Research Funds for the Central Universities,Grant No.2572018AB10the Fundamental Research Funds for the Central Universities,Grant No.2572019BB07.
文摘As a kind of biopolymer,hydrolysates of fish swim bladder,safer than those of land mammals,are widely used in food,cosmetics as well as pharmaceutical and biomedical fields for their biocompatibility,biodegradability,and weak antigenicity.To enhance hydrolysate production,in this paper,the papain and alcalase hydrolysis processes of larimichthys polyactis swim bladder were optimized with orthogonal experiments.With 89.5%hydrolysate yield,the optimal processing conditions for alcalase were solid-liquid ratio of 1:30,enzyme concentration of 0.7%,and extraction time of 6 h.As for papain,under the optimal processing conditions:solid-liquid ratio of 1:20,enzyme concentration of 0.5%,and extraction time of 8 h,the hydrolysate yield was 65.1%.To obtain higher hydrolysate yields,the ultrasonic pretreatments were implemented before the optimal enzyme hydrolysis processes.With ultrasonic waves of 100 W for 50 min,the hydrolysate yields were increased 2.1%(alcalase)and 4.5%(papain),respectively.The Fourier Transform Infrared(FTIR)spectroscopic analysis revealed that the hydrolysates extracted by papain exist in triple-helical forms.The Ultra-Violet(UV)absorption spectra indicated that the aromatic amino acids in the hydrolysates had strong absorptions in the wavelength range of 240 nm–300 nm.The results of this research demonstrate that the alcalase hydrolysates have better solubility in water and the solution is more stable under ambient temperature.However,the hydrolysates extracted by papain have a gel property and are insoluble in weak acid at room temperature,which is more suitable for applications in feedstock of biomedical.
基金This work has been supported in part by the National Natural Science Foundation of China(NSFC),under grants Nos.72101168,72071135.
文摘Social trust network(STN)and minimum cost consensus(MCC)models have been widely used to address consensus issues in multi-attribute group decision-making(MAGDM)problems with limited resources.However,most researchers have overlooked the decision maker‘(DMs)’confidence levels(CLs)and adjustment willingness implicit in their evaluations.To address these problems,this paper explores a confidence-based MCC model that considers DMs’adjustment willingness in the STN.The proposed model includes several modifications to the traditional trust propagation and consensus optimization models.Firstly,the improved method for measuring CLs of DMs and the confidence-based normalization approach are defined,respectively.Secondly,the bounded trust propagation operator is proposed,which considers the credibility of mediators to complete the STN.Thirdly,the identification rules based on the consensus index and CL are defined,and the MCC model with personalized cost functions and acceptable adjustment thresholds is built to automatically generate adjustment values for non-consensus DMs.Finally,a model to identify the non-cooperative behavior at the element level is established and the hybrid MCC model with persuasion strategies is provided.Finally,a case study is processed to verify the applicability of the proposed model,and comparison and sensitivity analysis are conducted to highlight its benefits.
