Phosphotungstic acid immobilized on amino-functionalized TS-1 zeolite as a solid acid catalyst for the synthesis of tributyl citrate

The amino-functionalization of TS-1 zeolite followed by immobilization of phosphotungstic acid(HPW)was presented to prepare a strong solid acid catalyst for the synthesis of bio-based tributyl citrate from the esterification of citric acid and n-butanol.γ-Aminopropyltriethoxysilane(APTES)was first grafted on the TS-1 zeolite via the condensation reactions with surface hydroxyl groups,and subsequently the HPW was immobilized via the reaction between the amino groups and the protons from HPW-forming strong ionic bonding.The Keggin structure of HPW and MFI topology of TS-1 zeolite were well maintained after the modifications.The amino-functionalization generated abundant uniformly distributed active sites on TS-1 for HPW immobilization,which promoted the dispersity,abundance,as well as the stability of the acid sites.The tetrahedrally coordinated framework titanium and non-framework titania behaved as weak Lewis acid sites,and the protons from the immobilized HPW acted as the moderate or strong Brønsted acid sites.An optimized TBC yield of 96.2%(mol)with a conversion of-COOH of 98.1%(mol)was achieved at 150℃for 6 h over the HPW immobilized on amino-functionalized TS-1.The catalyst exhibited good stability after four consecutive reaction runs,where the activity leveled off at still a relatively high level after somewhat deactivation possibly caused by the leaching of a small portion of weakly anchored APTES or HPW.

A Denoiser for Correlated Noise Channel Decoding: Gated-Neural Network

This letter proposes a sliced-gated-convolutional neural network with belief propagation(SGCNN-BP) architecture for decoding long codes under correlated noise. The basic idea of SGCNNBP is using Neural Networks(NN) to transform the correlated noise into white noise, setting up the optimal condition for a standard BP decoder that takes the output from the NN. A gate-controlled neuron is used to regulate information flow and an optional operation—slicing is adopted to reduce parameters and lower training complexity. Simulation results show that SGCNN-BP has much better performance(with the largest gap being 5dB improvement) than a single BP decoder and achieves a nearly 1dB improvement compared to Fully Convolutional Networks(FCN).

Lower extremity peripherally inserted central catheter placement ectopic to the ascending lumbar vein:A case report

BACKGROUND Peripherally inserted central catheters(PICCs)are an essential infusion route for oncology patients receiving intravenous treatments,but lower extremity veni-puncture is the preferred technique for patients with superior vena cava syndrome(SVCS).We report the case of a patient with a lower extremity PICC ectopic to the ascending lumbar vein,to indicate and verify PICC catheterisation in the lower extremity is safe and feasible.And hope to provide different per-spectives for clinical PICC venipuncture to get the attention of peers.CASE SUMMARY On 24 August 2022,a 58-year-old male was admitted to our department due to an intermittent cough persisting for over a month,which worsened 10 d prior.Imaging and laboratory investigations suggested the patient with pulmonary malignancy and SVCS.Chemotherapy was not an absolute contraindication in this patient.Lower extremity venipuncture is the preferred technique because administering upper extremity venous transfusion to patients with SVCS can exacerbate oedema in the head,neck,and upper extremities.The patient and his family were informed about the procedure,and informed consent was obtained.After successful puncture and prompt treatment,the patient was discharged,experiencing some relief from symptoms.CONCLUSION Inferior vena cava catheterisation is rare and important for cancer patients with SVCS,particularly in complex situations involving ectopic placement.

Elastic Buckling of Bionic Cylindrical Shells Based on Bamboo

High load-bearing efficiency is one of the advantages of biological structures after the evolution of billions of years. Biomimicking from nature may offer the potential for lightweight design. In the viewpoint ofrnechanics properties, the culm of bamboo comprises of two types of cells and the number of the vascular bundles takes a gradient of distribution. A three-point bending test was carried out to measure the elastic modulus. Results show that the elastic modulus of bamboo decreases gradually from the periphery towards the centre. Based on the structural characteristics of bamboo, a bionic cylindrical structure was designed to mimic the gradient distribution of vascular bundles and parenchyma cells. The buckling resistance of the bionic structure was compared with that of a traditional shell of equal mass under axial pressure by finite element simulations. Results show that the load-bearing capacity of bionic shell is increased by 124.8%. The buckling mode of bionic structure is global buckling while that of the conventional shell is local buckling.

Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury

Vision depends on accurate signal conduction from the retina to the brain through the optic nerve,an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.The mammalian optic nerve,an important part of the central nervous system,cannot regenerate once it is injured,leading to permanent vision loss.To date,there is no clinical treatment that can regenerate the optic nerve and restore vision.Our previous study found that the mobile zinc(Zn^(2+))level increased rapidly after optic nerve injury in the retina,specifically in the vesicles of the inner plexiform layer.Furthermore,chelating Zn^(2+)significantly promoted axonal regeneration with a long-term effect.In this study,we conditionally knocked out zinc transporter 3(ZnT3)in amacrine cells or retinal ganglion cells to construct two transgenic mouse lines(VGAT^(Cre)ZnT3^(fl/fl)and VGLUT2^(Cre)ZnT3^(fl/fl),respectively).We obtained direct evidence that the rapidly increased mobile Zn^(2+)in response to injury was from amacrine cells.We also found that selective deletion of ZnT3 in amacrine cells promoted retinal ganglion cell survival and axonal regeneration after optic nerve crush injury,improved retinal ganglion cell function,and promoted vision recovery.Sequencing analysis of reginal ganglion cells revealed that inhibiting the release of presynaptic Zn^(2+)affected the transcription of key genes related to the survival of retinal ganglion cells in postsynaptic neurons,regulated the synaptic connection between amacrine cells and retinal ganglion cells,and affected the fate of retinal ganglion cells.These results suggest that amacrine cells release Zn^(2+)to trigger transcriptomic changes related to neuronal growth and survival in reginal ganglion cells,thereby influencing the synaptic plasticity of retinal networks.These results make the theory of zinc-dependent retinal ganglion cell death more accurate and complete and provide new insights into the complex interactions between retinal cell networks.

Multiblock poly(ether-b-amide)copolymers comprised of PA1212 and PPO-PEO-PPO with specific moisture-responsive and antistatic properties

Functional multiblock poly(ether-b-amide)(PEBA)copolymers,comprised of PA1212(polyamide 1212)as hard segments and Jeffamine ED-2003 as soft segments,were successfully prepared via two-step melt polycondensation without any amidation catalyst.Here,using diamino-terminated poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide)(PPO-PEO-PPO),Jeffamine ED-2003,enhances the compatibility between polyamide oligomer and polyether,which is better than the traditional route using hydroxyl-terminated polyether.The chemical structure of multiblock PEBAs,as well as the microphase separated structure with crystalline phase of polyamide and polyether,were confirmed by heteronuclear multiple-bond correlation spectrum,heteronuclear multiple quantum correlation spectrum,Fourier transform infrared spectroscopy(FT-IR),differential scanning calorimetry and dynamic mechanical analysis.The hydrophilic PEBA copolymers showed water adsorption ranging from 87.3%to 17.1%depending on the polyether content,and specially showed moisture responsive behavior within seconds when exposed to moisture.The corresponding mechanism was studied using time-resolved attenuated total reflectance FT-IR spectroscopy in the molecular level and the water diffusion coefficient was estimated to be 1.07×10^(–8)cm^(2)∙s^(-1).Two-dimensional correlation FT-IR spectra analysis was performed to confirm that the interaction between water and polyether phase was in preference to that between water and polyamide matrix,and water molecule only forms hydrogen bond with the polyether segment.Due to the incorporation of PEO segments,the PEBAs have the surface resistivity varying from 5.6×10^(9)to 6.5×10^(10)Ω,which makes PEBA potential candidate as permanent antistatic agent.

Understanding the interfacial behaviors of benzene alkylation with butene using chloroaluminate ionic liquid catalyst: A molecular dynamics simulation

To better understand the benzene alkylation with chloroaluminate ionic liquids(ILs) as catalyst, the interfacial properties between the benzene/butene binary reactants and chloroaluminate ILs with varying cation alkyl chain length and different anions were investigated using molecular dynamics(MD) simulations. The results indicate that ILs can obviously improve the interfacial width, solubility and diffusion of reactants compared to H_(2)SO_(4). The longer alkyl chains of cations present a density enrichment at the interface and protrude into the binary reactants phase. Furthermore, the ILs consisting of 1-octyl-3-methylimidazolium cations([Omim]^(+)) and the stronger acidity heptachlorodialuminate anions([Al_(2)Cl_(7)]^(-)) are more beneficial to promote the interfacial width and facilitate the dissolution and diffusion of benzene in both the IL bulk and the interfacial region in comparison to the ones with shorter alkyl chains cations and weaker acidity anions. The information gives us a better guideline for the design of ILs for benzene alkylation.

Efficacy of lidocaine wet compress combined with red-light irradiation for chronic wounds

BACKGROUND Chronic wounds that fail to progress through normal phases of healing present a significant healthcare burden owing to prolonged treatment and associated costs.Traditional wound care typically involves regular dressing changes,which can be painful.Recent approaches have explored the use of lidocaine to manage pain and red-light irradiation(RLI),known for its anti-inflammatory and cell proliferation effects,to potentially enhance wound healing.AIM To investigate the therapeutic efficacy of lidocaine wet compression(LWC)combined with RLI for chronic wounds.METHODS We enrolled 150 patients with chronic wounds from the Wound and Ostomy Outpatient Clinic of the Second Hospital of Anhui Medical University from April to September 2022.The wounds were treated with dressing changes.The patients were randomly assigned to the control and experimental groups using a random number table and given the same first dressing change(2%LWC for 5 min and routine dressing change).From the second dressing change,in addition to 2%LWC for 5 min and routine dressing change,the experimental group received RLI,whereas the control group continued to receive the same LWC and dressing change.The first and second dressing changes were performed on days 1 and 2,respectively.The third dressing change was performed 3 d after the second change.The frequency of subsequent dressing changes was determined based on wound exudation and pain.Pain during the first three dressing changes was evaluated in both groups.The average number of dressing changes within 28 d and the degree of wound healing on day 28 were also recorded.RESULTS During the initial dressing change,no noticeable differences were observed in the pain levels experienced by the two groups,indicating similar pain tolerance.However,during the second and third dressing changes,the experimental group reported significantly less pain than the control group.Furthermore,over 28 d,the experimental group required fewer dressing changes than the control group.CONCLUSION Notably,the effectiveness of wound healing on the 28th day was significantly higher in the experimental group than that of in the control group.The combination of LWC and RLI was effective in reducing early-stage pain,promoting wound healing,decreasing the frequency of dressing changes,and enhancing patients’overall quality of life with chronic wounds.

江苏省优良食味粳稻的遗传与育种研究

为了培育适合在江苏种植的优良食味粳稻品种,以优良食味为主攻目标,对江苏省优质、抗病、高产粳稻品种的遗传基础开展了系统研究。通过关联分析,研究稻米蒸煮品质、营养品质与食味品质的关系,明确直链淀粉含量是影响食味品质的关键性状。直链淀粉含量为10%~14%的半糯米米饭表面光泽透亮、质地柔软、富有弹性,综合了糯米的柔软性和粳米的弹性,冷饭不硬,食味品质极佳,符合长三角地区人们喜食柔软香型粳米的口感需求。筛选出直链淀粉含量在10%左右、含有低直链淀粉含量基因Wx^(mp)的日本半糯粳稻品种“关东194”作为食味品质改良的核心种质。开发Wx^(mp)基因的分子标记,结合利用与抗病、高产相关基因紧密连锁的分子标记,开展优良食味、抗病、高产粳稻聚合育种。育成适合江苏省不同稻区种植的南粳46、南粳5055、南粳9108和南粳5718等优良食味粳稻系列新品种通过审定,形成了覆盖江苏省不同稻区的优良食味粳稻品种布局,累计推广面积超过533万公顷,有力地促进了江苏省及周边地区优质稻米产业的发展,为水稻产业供给侧结构调整,提质增效,保障粮食安全作出了重要贡献。

Application of Caenorhabditis elegans in screening active ingredients of traditional Chinese medicine

People continue to recognize the important role of Chinese medicine in the treatment of diseases,and there is an urgent need to clarify the mechanism of Chinese medicine.Because of the multi-target and multi-component characteristics of traditional Chinese medicine,it is difficult to elaborate from a single perspective.As a high-quality animal model,Caenorhabditis elegans with the characteristics of small size and fast reproduction,has been widely used in traditional Chinese medicine activity experiments.In this article,Caenorhabditis elegans,as model organisms used to screen the active components of traditional Chinese medicine were reviewed.

后交叉韧带撕裂的典型临床特征分析及关节镜手术与保守治疗的疗效比较

目的观察后交叉韧带撕裂的典型临床特征,并分析关节镜手术与保守治疗的疗效比较。方法该研究收集后交叉韧带撕裂的患者128例进行研究,其中接受关节镜手术治疗的患者共63例,保守治疗组患者65例,两组患者进行膝关节损伤及功能评价的相关临床检查,包括胫骨移位水平以及两种评分体系评分等,统计分析使用SPSS 17.0统计软件包。结果两组患者接受手术治疗后随访24个月,后抽屉试验(PDT)结果显示,关节镜手术组PDT评分总体情况优于保守治疗组,根据Lysholm和Tegner两种评分标准进行疗效评价,术后关节镜手术组Lysholm评分明显高于保守治疗组得分,关节镜组Tegner评分与保守治疗组差异无统计学意义(P>0.05)。结论关节镜下手术治疗后交叉韧撕裂损伤的疗效较保守治疗更优,特别是表现在治疗后关节稳定性等方面。

激光冲击强化ZCuAl10Fe3Mn2合金的热疲劳裂纹生长行为

为了提高高温构件的热疲劳性能、减少表面裂纹,研究激光冲击对ZCuAl10Fe3Mn2合金硬度、表面形貌、残余应力和热疲劳性能的影响。采用扫描电子显微镜(SEM)和能谱仪(EDS)分析合金的显微组织和裂纹形貌。结果表明:在4 J脉冲能量下,激光冲击能显著改善合金的热疲劳性能。在热应力和交变应力的作用下,试样缺口附近组织氧化而变得疏松多孔,促使萌生多条微裂纹。其中,竖直方向的微裂纹变为主裂纹,主要以裂尖前沿空洞连体的形式扩展;其他方向的微裂纹沿晶界生长而发生组织脱落现象。

狂犬病小鼠模型的制作

目的建立狂犬病病毒感染动物疾病模型。方法狂犬病病毒CVS-B2C毒株以10LD50剂量腿部肌肉注射接种4~6周龄的BALB/c小鼠,0.2 mL/只,于BSL2实验室负压IVC设备内饲养观察,并对其模型进行评价。结果小鼠接种狂犬病病毒后一周左右就出现临床症状,表现为饮食量下降,毛皮慢慢失去原先的光泽,体重下降,并出现麻痹等症状,进而死亡,部分小鼠出现躁狂的症状或抽搐性和强直性痉挛,而对照组小鼠则表现正常。DFA法检测结果：感染上狂犬病毒的小鼠脑组织涂片中出现特异性荧光抗体染色反应,而对照组动物的小鼠脑组织涂片未出现荧光抗体染色反应。RT-PCR法检测结果：从感染小鼠脑组织标本中提取病毒RNA,引物扩增出的目的基因片段,大小约为1kb,为N蛋白。免疫组化法检测结果：感染狂犬病毒的小鼠脑切片显示出棕色阳性颗粒,对照组小鼠脑切片染色阴性。病理检测结果：HE染色可见感染小鼠脑组织炎性细胞浸润,神经细胞胞质内出现内基体以及神经细胞退行性病变。结论成功的复制出小鼠狂犬病病毒感染模型,为研究和控制狂犬病奠定了基础。

Action Mechanism of Antibacterial Hydrolysate from Ruditapes philippinarum

[Objectives] The antibacterial mechanism of protein hydrolysate from Ruditapes philippinarum（ named RPPH） was studied in this article. [Methods]The integrity of bacteria＇s wall and membrane was determined by some traditional ways. [Results]The growth of Staphylococcus aureus and Bacillus subtilis were inhibited by RPPH in the logarithmic phase. The activity of alkaline phosphatase could be detected in the culture solution. The results showed that the protein content and the conductivity of two kinds of bacteria increased with the extension of incubation time. The results of scanning electron microscope revealed that it emerged the phenomenon of agglomeration with the extension of response time in the culture solution of S. aureus,and the cell shape became irregular,a large number of cells stuck together,afterwards intracellular material was released from bacteria,and the boundaries among cells completely disappeared. The cell surface of B. subtilis became rough,the cells began to adhere,intercellular boundaries became blurred,subsequently cells broke,and then intracellular material leaked out after treating for 9 h. The form of B. subtilis could be roughly identified from the remnants of the bacterial debris,and most of the bacteria had been completely cracked and died. Transmission electron microscope results showed that the surface of S. aureus became rough,with uneven distribution of cytoplasm,and darker substances appeared in the middle,followed by leakage of large numbers of intracellular material. Massive cells became dead when treating for 9 h. B. subtilis cells began to shrink,and cytoplasm was distributed unevenly. The significant phenomenon of plasmolysis and rupture of cell wall could be observed. Afterwards,intracellular material spilled out,only the residual and ambiguity nucleoplasm area could be seen,and cells were killed. [Conclusions] Therefore,it was speculated that the RPPH could destroy cell wall and membrane of the two kinds of bacteria,change the permeability of cells membrane,result in the leakage of intracellular substances and enter within the bacterial cells to affect their normal physiological metabolism which led to death.

数学建模课程中的几点思考

为了适应我国教育改革的需要,数学建模进入了大学课堂。如何安排好数学建模课程教学,培养学生利用数学的方法解决实际问题的能力,这是一个值得思考的问题。本文针对数学建模课程中的一些特点和问题,探索出一些解决这些问题的教学方法和手段。

三种气温预报产品黑龙江省预报效果检验

利用T639模式预报产品和黑龙江省83个国家气象站气温实况观测资料,采用最优预报因子方法选取预报因子,应用多元回归方法建立逐站日最高气温和日最低气温的MOS预报方程;对MOS、中央气象台指导预报(SCMOC)和T639三种气温预报产品的日最高气温和日最低气温预报效果进行对比检验分析,并用EOF方法检验预报与实况的时空变化特征一致性。结果表明:与实况的时空变化一致性方面,MOS和SCMOC较好,T639略差;预报效果方面,MOS和SCMOC对日最高气温和日最低气温的2℃预报准确率普遍高于T639,MOS的预报准确率在日最高气温方面高于SCMOC,在日最低气温方面低于SCMOC;MOS对T639气温预报产品改善效果明显,尤其对冬季日最低气温的预报改善效果十分显著;MOS较T639气温预报改善效果与T639模式预报效果呈负相关关系,主要表现为,MOS预报改善效果在T639预报准确率低的山区明显优于平原,在春、夏季,预报准确率较低的日最高气温明显优于日最低气温,在冬季,预报准确率较低的日最低气温优于日最高气温;MOS气温预报方法的预报性能较理想,SCMOC对黑龙江省预报难度较大的日最低气温预报效果较好。

不同发酵条件对小台农芒果酒中的Vc含量及风味的影响

为了研究不同发酵条件对小台农芒果酒中的Vc含量和风味的影响,以海南小台农芒果为主要原料,以不同梯度的果胶酶、酵母添加量和发酵时间为单因素实验,测定Vc、总糖、滴定酸、可溶性固形物等指标,在此基础上进行L33正交实验,确定最佳酿造工艺。结果筛选出两种工艺,一种工艺为果胶酶添加量为0.15%,酵母添加量为0.20 g/L,发酵时间为7 d,此工艺下酿造的小台农芒果酒总体评分最高为85分,Vc为33.89 mg/100 g,具有浓郁的芒果香气,酒体结构感强,酒香与果香融合较好,余味较长;另一种工艺为果胶酶添加量0.20%,酵母添加量0.20 g/L,发酵时间8 d,在此工艺下芒果酒最终评分为74,Vc含量为37.27 mg/100 g,但其酒精度较高,酒体较淡薄,结构感不强,后味略苦。因此,从风味上考虑,则优选第一种工艺为佳,果胶酶添加量为0.15%、酵母添加量为0.20g/L、发酵时间为7d;从Vc含量上考虑,则第二种工艺为最佳选择,果胶酶添加量为0.2%、酵母添加量为0.20 g/L、发酵时间为8d。

Andrews六要素指导下不同治疗方案对骨性Ⅱ类患者审美评价的影响

目的评价依据Andrews六要素制定的不同治疗方案对骨性Ⅱ类患者侧貌美观的影响,并研究正畸医生与非专业人员审美评价的差异。方法选取一名符合实验标准的骨性Ⅱ类患者作为研究对象,使用Dolphin Imaging导入试验对象头颅侧位片,与侧貌照片进行重叠,以Andrews六要素理论为指导制定正畸掩饰性治疗方案、正畸代偿结合颏成形方案及正畸-正颌方案,得到相应的侧貌彩图后用Photoshop转变成侧貌剪影图,选取正畸医生和非专业人员根据Likert量表对6张剪影图进行评分。结果两组评分者均认为根据Andrews六要素制定的正畸正颌双颌手术方案侧貌最美观,正畸代偿结合颏成形方案中颏部前移8 mm次之。在专业组中,原始侧貌得分明显低于非专业组,而双颌手术侧貌得分明显高于非专业组。结论对于下颌后缩的骨性Ⅱ类患者,根据Andrews六要素制定的正畸正颌双颌手术方案是最佳治疗方式,而在正畸代偿辅以颏成形术方案中,通过Andrews六要素制定的颏部前移量最有利于患者改善侧貌美观。专业组与非专业组之间存在审美差异。

面部生长型对侧貌唇突度的影响

目的:研究面部生长型对美观侧貌唇突度的三维审美评价的影响,并分析其结果是否在正畸医生和非专业人士之间有所不同。方法:选取一名面部协调美观且面部软硬组织各测量值均在Holdaway软组织分析法正常值范围内的成年女性志愿者,拍摄正侧位照片导入3D MAX软件制成三维头部模型,改变面型及唇突度后生成45个三维头模。选取正畸医生和非专业人员根据Likert量表对其进行评分。结果:两组评价者对平均生长型-矢状向正常骨面型的模型评分较高(P<0.05),对于其他骨性不协调评价较低,其中在平均生长型-下颌前突,垂直生长型-矢状向正常、垂直生长型-下颌前突,水平生长型-下颌前突中,较突出的唇部位置(+2 mm)评分较高(P<0.05),而平均生长型-下颌后缩,垂直生长型-下颌后缩,水平生长型-下颌后缩,稍微后缩的唇部位置(-2 mm)评分较高(P<0.05)。不同面部生长型对于不同矢状骨面型唇部位置改变量为(-4 mm)、(-2 mm)、(0 mm)、(+2 mm)、(+4 mm)时的评价均呈现显著性差异,具有统计学意义(P<0.05)。结论:美观侧貌的唇部位置不仅受到矢状向面部类型的影响,还受到面部生长型的影响。口腔正畸医生和非专业人士审美敏感性不同,审美趋势大致一致,专业人士较苛刻。