期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Diagnosis and treatment of primary pulmonary enteric adenocarcinoma:Report of Six cases 被引量:1
1
作者 ling-fang tu Ling-Yan Sheng +4 位作者 Jian-Ying Zhou Xue-Fen Wang Yue-Hong Wang Qian Shen Yi-Hong Shen 《World Journal of Clinical Cases》 SCIE 2021年第30期9236-9243,共8页
BACKGROUND Primary pulmonary enteric adenocarcinoma(PEAC)is a very rare subtype of invasive adenocarcinoma,and there have been no large studies on PEAC to date.Therefore,it is necessary to obtain much more information... BACKGROUND Primary pulmonary enteric adenocarcinoma(PEAC)is a very rare subtype of invasive adenocarcinoma,and there have been no large studies on PEAC to date.Therefore,it is necessary to obtain much more information about the clinical and pathological features,diagnosis,differential diagnosis,and treatment of PEAC.CASE SUMMARY All clinical data of six patients with confirmed PEAC from 2013 to 2018 were collected,and data on diagnosis,differential diagnosis,and treatment of PEAC are discussed combined with all the associated literature.The mean age of six patients was 64.0±5.6(59-73)years old.Their clinical manifestations were heterogeneous,and during their disease course,there were no gastrointestinal symptoms.There was no evidence from colonoscopy or imaging studies to suggest digestive tract tumors or new metastases.The most commonly mutated gene was KRAS(50.0%),and the pathological features of the six cases were similar to those of colorectal cancer.CDX2(83.3%)and CK7(66.7%)had the highest positive rates upon immunohistochemical examination.In the associated literature,252 cases were identified,and the most commonly mutated gene was KRAS(42.9%).Additionally,CDX2(68.3%)and CK7(85.8%)had the highest positive rates.Patients mainly received surgery,chemotherapy,and radiotherapy,immunotherapy was not included.CONCLUSION Positive results for CDX2 and CK7 play an important role in the diagnosis and differential diagnosis of PEAC,and immunotherapy or targeted therapy focused on KRAS needs to be further studied for the treatment of PEAC. 展开更多
关键词 Pulmonary enteric adenocarcinoma IMMUNOHISTOCHEMISTRY Diagnosis Treatment KRAS Case report
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部