Background:Post-operative recurrence rates are high for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).This study aimed to explore the factors associated with post-operative 1-year recurrence rate in pat...Background:Post-operative recurrence rates are high for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).This study aimed to explore the factors associated with post-operative 1-year recurrence rate in patients with HBV-related HCC who had a single small primary tumor(3 cmin diameter).Methods:This was a retrospective study of 203(training cohort)and 64(validation cohort)patients newly diagnosed with HBV-related HCC who had a single small primary tumor.The first year of post-operative follow-up was examined.Factors potentially associated with HCC recurrence were identified using Cox regression analyses.A model was constructed based on the factors identified and the prognostic value of the model was evaluated using receiver operating characteristic(ROC)curve analysis and calculation of the area under the ROC curve(AUC).Results:A history of alcoholismand serum levels of a-fetoprotein,total protein and c-glutamyl transpeptidase(GGT)were independently associated with 1-year recurrence rate after surgery.A predictive model based on these four factors had an AUC of 0.711(95%confidence interval,0.643–0.772)in the training cohort and 0.727(95%confidence interval,0.601–0.831)in the validation cohort.The 1-year recurrence rate was significantly lower in the low-risk group than in the high-risk group in both the training cohort(17.0%vs.49.5%,P<0.001)and the validation cohort(43.2%vs.74.1%,P=0.031).Conclusion:A history of alcoholism and serum levels of a-fetoprotein,total protein and c-glutamyl transpeptidase were independently associated with post-operative 1-year recurrence rate in patients with HBV-related HCC who had a single small primary tumor(3 cmin diameter).展开更多
基金This study was supported by the Beijing Municipal Science and Technology Commission[No.Z171100001017082]the Special Fund of Capital Health Research and Development[No.2016–2-2171]+1 种基金the Fund for Beijing Science&Technology Development of TCM[No.JJ2016-14]the Science and Technology Project of Beijing Municipal Education Commission[No.SQKM201610025026].
文摘Background:Post-operative recurrence rates are high for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).This study aimed to explore the factors associated with post-operative 1-year recurrence rate in patients with HBV-related HCC who had a single small primary tumor(3 cmin diameter).Methods:This was a retrospective study of 203(training cohort)and 64(validation cohort)patients newly diagnosed with HBV-related HCC who had a single small primary tumor.The first year of post-operative follow-up was examined.Factors potentially associated with HCC recurrence were identified using Cox regression analyses.A model was constructed based on the factors identified and the prognostic value of the model was evaluated using receiver operating characteristic(ROC)curve analysis and calculation of the area under the ROC curve(AUC).Results:A history of alcoholismand serum levels of a-fetoprotein,total protein and c-glutamyl transpeptidase(GGT)were independently associated with 1-year recurrence rate after surgery.A predictive model based on these four factors had an AUC of 0.711(95%confidence interval,0.643–0.772)in the training cohort and 0.727(95%confidence interval,0.601–0.831)in the validation cohort.The 1-year recurrence rate was significantly lower in the low-risk group than in the high-risk group in both the training cohort(17.0%vs.49.5%,P<0.001)and the validation cohort(43.2%vs.74.1%,P=0.031).Conclusion:A history of alcoholism and serum levels of a-fetoprotein,total protein and c-glutamyl transpeptidase were independently associated with post-operative 1-year recurrence rate in patients with HBV-related HCC who had a single small primary tumor(3 cmin diameter).
