Stomach cancer is the fourth leading cause of cancer-related deaths worldwide[1].There are approximately one million new cases of gastric cancer worldwide each year,with about 45%occurring in China[1].In China,the num...Stomach cancer is the fourth leading cause of cancer-related deaths worldwide[1].There are approximately one million new cases of gastric cancer worldwide each year,with about 45%occurring in China[1].In China,the number of deaths from gastric cancer ranks second among all tumors each year[2],the majority of patients are diagnosed at an advanced or late stage,making them ineligible for surgical treatment.Some of these patients can regain the opportunity for surgery through conversion therapy,while more patients can only receive comprehensive treatment with cytotoxic drugs,anti-metabolite drugs,DNA-targeting drugs,and targeted drugs[3].展开更多
Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides,named ypsilandrosides U-X(1-4),and one new cholestanol glycoside,named ypsilandroside Y(5).Their struc...Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides,named ypsilandrosides U-X(1-4),and one new cholestanol glycoside,named ypsilandroside Y(5).Their structures have been established by extensive spectroscopic data and chemical methods.Among them,compound 4 is a rare spirostanol glycoside which possesses a novel 5(6→7)abeo-steroidal aglycone,while compound 1 is a first spiro-stanol bisdesmoside attached to C-3 and C-12,respectively,isolated from the genus Ypsilandra.The induced platelet aggregation activity of the isolates was tested.展开更多
Acute appendicitis is one of the most common surgical diseases in the general population, but it rarely happens after orthotopic liver transplantation （OLT）, The impaired immune function in these patients usually pr...Acute appendicitis is one of the most common surgical diseases in the general population, but it rarely happens after orthotopic liver transplantation （OLT）, The impaired immune function in these patients usually predisposes them to a delay in diagnosis owing to an atypical presentation, which might increase complications including death. It is reported that acute appendicitis after liver transplantation happens mostly after postoperative day （POD） 14. Herein, we presented two cases of acute appendicitis after OLT happened within POD 14.展开更多
Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese population.We aimed to examine the independent...Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese population.We aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern China.Methods:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 years.Baseline self-reported PA and SB were collected via the questionnaire.Kaplan–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause mortality.Results:A total of 11,744 eligible participants were included in the analysis.Over an average of 5.4 years of follow-up,796 deaths occurred.The risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SB<6 h(7.8%vs.6.0%;HR:1.37,95%CI:1.17–1.61).Participants with prolonged SB(≥6 h)and inadequate PA(low to moderate)had a higher risk of all-cause mortality compared to those with SB<6 h and high PA(11.2%vs.4.9%;HR:1.67,95%CI:1.35–2.06).Even in the participants with high PA,prolonged SB(≥6 h)was still associated with the higher risk of all-cause mortality compared with SB<6 h(7.0%vs.4.9%;HR:1.33,95%CI:1.12–1.56).Conclusions:Among Chinese population,PA and SB have a joint association with the risk of all-cause mortality.Participants with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.展开更多
文摘Stomach cancer is the fourth leading cause of cancer-related deaths worldwide[1].There are approximately one million new cases of gastric cancer worldwide each year,with about 45%occurring in China[1].In China,the number of deaths from gastric cancer ranks second among all tumors each year[2],the majority of patients are diagnosed at an advanced or late stage,making them ineligible for surgical treatment.Some of these patients can regain the opportunity for surgery through conversion therapy,while more patients can only receive comprehensive treatment with cytotoxic drugs,anti-metabolite drugs,DNA-targeting drugs,and targeted drugs[3].
基金supported by the National Natural Science Foundation of China (U1802287 and 32000280)the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talentsthe State Key Laboratory of Phytochemistry and Plant Resources in West China (P2019-ZZ02).
文摘Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides,named ypsilandrosides U-X(1-4),and one new cholestanol glycoside,named ypsilandroside Y(5).Their structures have been established by extensive spectroscopic data and chemical methods.Among them,compound 4 is a rare spirostanol glycoside which possesses a novel 5(6→7)abeo-steroidal aglycone,while compound 1 is a first spiro-stanol bisdesmoside attached to C-3 and C-12,respectively,isolated from the genus Ypsilandra.The induced platelet aggregation activity of the isolates was tested.
文摘Acute appendicitis is one of the most common surgical diseases in the general population, but it rarely happens after orthotopic liver transplantation （OLT）, The impaired immune function in these patients usually predisposes them to a delay in diagnosis owing to an atypical presentation, which might increase complications including death. It is reported that acute appendicitis after liver transplantation happens mostly after postoperative day （POD） 14. Herein, we presented two cases of acute appendicitis after OLT happened within POD 14.
基金the National Natural Science Foundation of China(No.81760049)the Jiangxi Science and Technology Innovation Platform Project(No.20165BCD41005)+2 种基金the National Key R&D Program of China(No.2018YFC1312902)the Science and Technology Plan of Health Commission of Jiangxi Province(No.20185215)the Key Project of Education Department of Jiangxi Province(No.GJJ170013).
文摘Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese population.We aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern China.Methods:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 years.Baseline self-reported PA and SB were collected via the questionnaire.Kaplan–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause mortality.Results:A total of 11,744 eligible participants were included in the analysis.Over an average of 5.4 years of follow-up,796 deaths occurred.The risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SB<6 h(7.8%vs.6.0%;HR:1.37,95%CI:1.17–1.61).Participants with prolonged SB(≥6 h)and inadequate PA(low to moderate)had a higher risk of all-cause mortality compared to those with SB<6 h and high PA(11.2%vs.4.9%;HR:1.67,95%CI:1.35–2.06).Even in the participants with high PA,prolonged SB(≥6 h)was still associated with the higher risk of all-cause mortality compared with SB<6 h(7.0%vs.4.9%;HR:1.33,95%CI:1.12–1.56).Conclusions:Among Chinese population,PA and SB have a joint association with the risk of all-cause mortality.Participants with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.
