A new palladium-catalyzed annulative allylic alkylation(AAA)reaction of 2-(indol-2-yl)phenols with dual allylic electrophiles such as isobutylene dicarbonate and butene dicarbonate is described,leading to the regiosel...A new palladium-catalyzed annulative allylic alkylation(AAA)reaction of 2-(indol-2-yl)phenols with dual allylic electrophiles such as isobutylene dicarbonate and butene dicarbonate is described,leading to the regioselective synthesis of tetracyclic medium-sized cyclic ethers possessing a bridged aryl-indole scaf-fold,namely,benzo[2,3]oxocino[4,5-b]indoles and benzo[2,3]oxepino[4,5-b]indoles,in good to excellent yields.This protocol demonstrates a broad substrate scope,good compatibility with substituents and high regioselectivity,providing a catalytic and flexible method for creating bridged aryl-indole skeletons.展开更多
基金the National Natural Science Foundation of China(Nos.21971090 and 22271123).
文摘A new palladium-catalyzed annulative allylic alkylation(AAA)reaction of 2-(indol-2-yl)phenols with dual allylic electrophiles such as isobutylene dicarbonate and butene dicarbonate is described,leading to the regioselective synthesis of tetracyclic medium-sized cyclic ethers possessing a bridged aryl-indole scaf-fold,namely,benzo[2,3]oxocino[4,5-b]indoles and benzo[2,3]oxepino[4,5-b]indoles,in good to excellent yields.This protocol demonstrates a broad substrate scope,good compatibility with substituents and high regioselectivity,providing a catalytic and flexible method for creating bridged aryl-indole skeletons.
