Coca-Cola consumption vs fragmentation in the management of patients with phytobezoars:A prospective randomized controlled trial

BACKGROUND Gastric phytobezoars(GPBs)are very common in northern China.Combined therapy involving carbonated beverage consumption and endoscopic lithotripsy has been shown to be effective and safe.Existing studies on this subject are often case reports highlighting the successful dissolution of phytobezoars through Coca-Cola consumption.Consequently,large-scale prospective investigations in this domain remain scarce.Therefore,we conducted a randomized controlled trial to examine the effects of Coca-Cola consumption on GPBs.AIM To evaluate the impact of Coca-Cola on GPBs,including the dissolution rate,medical expenses,ulcer rate,and operation time.METHODS A total of 160 consecutive patients diagnosed with GPBs were allocated into two groups(a control group and an intervention group)through computer-generated randomization.Patients in the intervention group received a Coca-Cola-based regimen(Coca-Cola 2000-4000 mL per day for 7 d),while those in the control group underwent emergency fragmentation.RESULTS Complete dissolution of GPBs was achieved in 100% of the patients in the intervention group.The disparity in expenses between the control group and intervention group(t=25.791,P=0.000)was statistically significant,and the difference in gastric ulcer occurrence between the control group and intervention group(χ^(2)=6.181,P=0.013)was also statistically significant.CONCLUSION Timely ingestion of Coca-Cola yields significant benefits,including a complete dissolution rate of 100%,a low incidence of gastric ulcers,no need for fragmentation and reduced expenses.

二氧化碳充气对无痛结肠镜诊疗患者舒适度的影响

目的比较空气和二氧化碳充气对无痛结肠镜患者术后疼痛评分、腹胀持续时间及满意度的差异。方法将200例无痛结肠镜患者随机分成两组(空气组和二氧化碳组),分别记录结肠镜诊疗的时间,待患者苏醒后评估腹痛评分、腹胀持续时间及满意度评分,使用SPSS 16.0统计软件分析数据。结果空气组视觉模拟评分(VAS)为(1.42±0.55)分,二氧化碳组为(0.52±0.16)分,两组比较,差异有统计学意义(t=10.78,P<0.01);空气组腹胀持续时间(45.60±16.78)min,二氧化碳组腹胀时间(21.31±19.67)min,两组比较,差异有统计学意义(t=10.13,P<0.01);空气组结肠镜诊疗时间(10.55±5.33)min,二氧化碳组(10.96±5.23)min,两组比较,差异无统计学意义(t=-0.54,P>0.05);空气组无痛结肠镜患者术后满意度(92.46±1.93)分,二氧化碳组(99.95±0.36)分,两组比较,差异有统计学意义(t=-37.95,P<0.01)。结论无痛结肠镜诊治使用二氧化碳充气,明显减轻腹胀程度、减少VAS评分和缩短腹胀持续时间,提高患者舒适度和满意度。

上消化道异物急诊内镜处理的回顾性分析

目的展示急诊内镜下上消化道异物取出术的经验及创新的措施。方法该研究回顾性分析2013年1月-2016年11月在该院消化内镜室取出异物的251例患者,患者采取局部麻醉或静脉复合麻醉方法,应用软式内镜和各种内镜附件(鼠齿钳、鳄鱼钳、息肉勒除器、息肉抓钳、取石网篮、碎石器或者碎石工具套装和橡胶手套等)进行诊治。收集患者的一般资料(年龄、性别、异物类型)、麻醉种类、异物崁顿的位置、内镜附件的类型、并发症和成功率。结果 251例患者均通过内镜确诊为消化道异物,248例患者异物被成功取出,3例失败,其中1例患者行胸外科手术,1例行耳鼻喉科手术,1例患者因为没有症状和治疗风险而拒绝行异物取出术。192例有轻微黏膜损伤或出血,45例患者发现潜在疾病。结论急诊内镜下异物取出术是治疗消化道异物的最佳手段,因为其在安全性、有效性、费用低、微创方面有绝对优势,而且内镜治疗时还可以发现潜在消化系统疾病;创新性的手段可提高异物取出成功率。

Application of Intraoperative Contrast-Enhanced Ultrasound in the Resection of Brain Tumors

Objective:To investigate the value of routine intraoperative ultrasound(IU)and intraoperative contrast-enhanced ultrasound(ICEUS)in the surgical treatment of brain tumors,and to explore the utilization of ICEUS for the removal of the remnants surrounding the resection cavity.Methods:In total,51 patients who underwent operations from 2012 to 2018 due to different tumors in the brain were included in this study.The clinical data were evaluated retrospectively.IU was performed in all patients,among which 28 patients underwent ICEUS.The effects of IU and ICEUS on tumor resection and recurrence were evaluated.

基于ACO-BP NN的飞机零件橡皮囊成形起皱预测（英文）

利用ABAQUS/Explicit有限元分析软件对2A12-O态铝合金橡皮囊成形凸曲线弯边零件起皱现象进行分析,借助正交试验工具,进行了橡皮囊成形数值模拟试验。通过分析材料性能参数和工艺参数对凸弯边橡皮囊成形零件的影响,获取了影响凸曲线弯边零件起皱的主效应参数,并在此试验基础上建立了基于蚁群神经网络的起皱预测模型。在利用大量试验数据对其训练之后,使用该模型预测橡皮囊成形零件的起皱情况,同时对2A12-O态铝合金板材橡皮囊成形凸弯边零件进行工艺试验验证,结果表明:该模型能够在研究新零件成形过程中快速获得最佳成形参数,并且可以提高效率的工业,且预测误差控制在5%以内,且满足工业应用标准。

Effect of Different Drying Methods on the Volatile Compounds Jinmudan Oolong Tea

Jinmudan,a new tea variety from Fujian Province has an excellent quality with a unique aroma like magnolia frogrance.To monitor the changes in the tea volatile compounds during the Jinmudan Oolong tea manufacturing(drying) process,the volatiles of tea samples were extracted and analyzed.Characteristic volatile compounds in Jinmudan Oolong tea were nerolidol,α-farnesene,linolenic acid,palmitic acid,indole,phenylacetaldehyde,cisjasmone,β-phenylethanol,etc.The content of nerolidol was the highest in four tested samples.The composition of the volatile compounds in microwave drying sample was simple,but its concentration was high,in which the main volatile compounds were alcohols and esters.The processing with combination of traditional drying craft and modern aroma-improvement technique could obviously improve the tea aroma,especially in level of epoxy linalool and jasmine lactone.

A Study on Effects of Turn-over Technology on the Quality of Jinmudan Oolong Tea

This paper reported the effect of oolong tea processing procedure of turn-over on quality of the Jinmudan Oolong tea,including taste components and volatile compounds.The content of the water extractable solids was gradually increased,but the content of amino acid decreased and then increased,and the content of the soluble sugar and tea polyphenols increased after the first turn-over processing.The major volatiles of the three tested Jinmudan Oolong tea samples were nerolidolcistrans,α-farnesene,palmitic acid,indole and 9,12,15-octadecatrienoicacid and methyl ester.The sensory evaluation results showed that an appropriate increase in the number of turn-over was helpful to quality of the Jinmudan Oolong tea.

Pathogen Analysis of Superficial Mucocutaneous Mycosis in a Tertiary A-level Hospital from 2007 to 2018

Objective This study aimed to analyze the fungal species of pathogens isolated from patients with superficial mucocutaneous mycosis from May 2007 to December 2018.Methods A retrospective analysis was carried out to determine the pathogenic fungi isolated from patients with superficial fungal infections in the Medical Mycology Clinical Laboratory,Department of Dermatology and Venereology,Union Hospital,from May 2007 to December 2018.Results A total of 7639 strains were obtained,belonging to 21 genera and 36 species.They mainly consisted of Candida(3707/7639,48.53%)and dermatophytes(3594/7639,47.05%).The specimens were skin scales,nail shavings,secretions on the nail grooves,broken or diseased hair and dandruff,secretions or pseudomembrane of the external genitalia,and the oral mucosa.A total of 7300 patients were enrolled in this study,including 3301 males and 3999 females aged 2 months to 92 years old with a median age of 46.04 years old except for 633 patients whose ages were unknown.Two strains of different species were isolated from each of 339 patients at different body sites.The most frequent species were Trichophyton rubrum complex(2906/7639,38.04%),Candida albicans(2619/7639,34.28%),and unclassified Candida spp.Dermatophytes were mostly isolated from glabrous skin(2138/3594,59.49%),with T.rubrum complex being the predominant species.Candida strains were most commonly isolated from mucosal sites(1979/3707,53.39%),and C.albicans was the most prevalent causative agent.Conclusion The main distribution of pathogenic fungal species isolated from patients with superficial mycosis from 2007 to 2018 in Wuhan,Hubei province and the surrounding areas was that Candida slightly outnumbered dermatophytes.Among all of the isolated strains,T.rubrum complex was the most abundant.

Vertebral body infection due to esophageal perforation caused by ingestion of fishbone:a case report

Background:Esophageal injury is a common complication of foreign bodies in the upper gastrointestinal tract,but bilateral pleural effusion or vertebral infection is a rare condition due to a swallowed fishbone.It is considerably difficult for a physician to diagnose quickly because of incomplete patient history of foreign bodies ingestion and/or insufficient experiences.Patient concerns:We describe the case of a 56-year-old man who was admitted to an emergency medical department owing to a low to moderate fever for 7 days.After a series of examinations,the patient was diagnosed with esophageal perforation(EP)caused by a fishbone that was swallowed half a month ago.Diagnoses:About 12 days after the onset of fever,he was diagnosed with EP based on the gastric endoscopic images combined with histological section and sufficient history of the disease.About 2 months later,the patient has obvious back pain and lack of strength in two legs and was diagnosed with vertebral body infection.Interventions:Antibiotic therapy,multi-disciplinary team(MDT),and surgical intervention had been exerted.Outcomes:It is very fortunate for this patient to have a good prognosis due to a timely diagnosis and proper management.Muscle power has attained level 5.Lessons:Several lessons can be learned from this case;for example,physicians should be alerted to the EP,endoscopic intervention should be prompt,antibiotics should be used regularly,and so on.

Volatile Compounds in Two Camellia chrysantha(Hu)Tuyama Species

In the study,the volatile compounds in two Camellia chrysantha(Hu) Tuyama species were extracted and analysed by simultaneous steam distillation and extraction(SDE) and gas chromatography mass spectrometry(GCMS),respectively.The relative contents of the chemical constituents in the volatile components were quantified by peak area normalization and NIST database.A total of 60 volatile components were identified,45 for Camellia nitidissima and 26 for Camellia euphlebia.Aldehydes and acids were the most dominant volatiles in Camellia nitidissima,but for Camellia euphlebia there were hydrocarbons and ketones.Hexanoic acid,4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one,cis-2-decenal,4-[2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl]-3-buten-2-one,phenylacetaldehyde,eicosane,alpha-ionone,geranylacetone 2,6-di-tert-butyl-4-methylphenol,7,9-di-tertbutyl-1-oxaspiro[4,5]deca-6,9-diene-2,8-dioi and tetradecanal were both in two Camellia chrysantha(Hu)Tuyama species.

Analysis of Volatile Compounds of Jinmudan Oolong Tea by Different Wrapping-Twisting

In this study,the volatile compounds in four kinds of Jinmudan Oolong tea were extracted and analyzed by simultaneous steam distillation and extraction(SDE) and gas chromatography-mass spectrometry(GC-MS),respectively.The relative contents of the chemical constituents in the volatile components were quantified by peak area normalization and NIST database.A total of 93 volatile components were identified,46 for sample 1,56 for sample 2,45 for sample 3 and 30 for sample 4.Alcohols and esters were the most abundant volatiles in Jinmudan Oolong tea.Palmitic acid,nerolidol,2-phenylethanol,phytol,cis-5-ethenyltetrahydro-.α,α-5-trimethyl-2-furanmethanol,2,2,6-trimethyl-6-ethenyltetrahydro-2h-pyran-3-ol,a-farnesene,eicosane,hexadecane,indole,β-phenethyl hexanoate,β-phenethyl hexanoate,methyl palmitate,benzoic acid,2-phenylethyl ester,tetrahydro-6-(cis-2-pentenyl)-2h-pyran-2-one and cis-jasmone were in all of the samples.Nerolidol was shown to be the aroma components with the highest content in Jinmudan Oolong tea,which accounted for 26.61%,36.89%,36.89%and 36.89%.

Arabidopsis Sucrose Transporter SUT4 Interacts with Cytochrome b5-2 to Regulate Seed Germination in Response to Sucrose and Glucose

It remains unknown whether a sucrose transporter mediates sugar signaling. Here, we report that the Arabidopsis （Arabidopsis thaliana） sucrose transporter SUT4 interacts with five members of the Arabidopsis cytochrome b5 （Cyb5） family, and sucrose represses the interaction between SUT4 and a Cyb5 member Cyb5-2/A. We observed that down- regulation of SUT4 and three cytochrome b5 members （Cyb5-2, Cyb5-4, and Cyb5-6） confers the sucrose- and glucose- insensitive phenotypes in the sucrose/glucose-induced inhibition of seed germination. The sut4 cybS-2 double mutant displays slightly stronger sucrose/glucose-insensitive phenotypes than either the sut4 or cyb5-2 single mutant. We showed that the SUT4/Cyb5-2-mediated signaling in the sucrose/glucose-induced inhibition of seed germination does not require ABA or the currently known ABI2/ABI4/ABI5-mediated signaling pathway（s）. These data provide evidence that the sucrose transporter SUT4 interacts with Cyb5 to positively mediate sucrose and glucose signaling in the sucrose/ glucose-induced inhibition of seed germination.

Fracture Characteristics of Fully Pearlitic Steel Wire in Tension and Torsion

The fracture characteristics of fully pearlitic steel wires with fine and randomly oriented lamellae have been investigated after tension and torsion, respectively. It is found that the predominant fracture mode under small pre- deformation is dimple. The analysis of the colony size and the lamellar structure near the fracture surface indicates that each dimple roots from one colony. A simulation of tensile deformation with several pearlitic colonies based on the real scanning electron microscopy （SEM） observation shows that the plastic deformation concentrates and the stress t^hxialit~＂ is larger ~it the boundaries bf colonies. It demonstrates the microe/＇a^ks initialize at colony boundaries. Thus, the colony size is a significant factor for fracture behaviors under small pre-deformation. On the other hand, the fracture surface is investigated after large pre-deformation via torsion. The results show that fracture characteristics vary with radius from dimples, elongated dimples to the fibrous structure. It indicates that the fracture charac-teristics are dependent on the pre-deformation. The fracture mode under large pre-deformation becomes an anisotropic fibrous structure instead of dimples.

Influence of Lamellar Direction in Pearlitic Steel Wire on Mechanical Properties and Microstructure Evolution

During cold drawing of pearlitic steel wire, the lamellar structure becomes gradually aligned with the draw ing axis, which contributes to the ultra high strength. A direct simulation about the mechanical behaviors and microstructural evolution of pearlitic lamellae was presented. A representative volume element （RVE） containing one pearlitic colony was established based on the real transmission electron microscope （TEM） observation. The deformation of pearlitic colony during tension, shear and wire drawing were successfully simulated. The numerical results show that this metallographic texture leads to a strong anisotropy. The colony has higher yielding stress when the la mellar direction is parallel and perpendicular to the tensile direction. The lamellar evolution is strongly dependent on the initial direction and deformation mode. The formation of typical period shear bands is analyzed. In the wire draw ing, the pearlitic colony at the sub surface experiences a complex strain path： rotation, stretching along the die sur face, and rotation back.