Artificial intelligence promotes shared decision-making through recommending tests to febrile pediatric outpatients

BACKGROUND:To promote the shared decision-making(SDM)between patients and doctors in pediatric outpatient departments,this study was designed to validate artificial intelligence(AI)-initiated medical tests for children with fever.METHODS:We designed an AI model,named Xiaoyi,to suggest necessary tests for a febrile child before visiting a pediatric outpatient clinic.We calculated the sensitivity,specificity,and F1 score to evaluate the efficacy of Xiaoyi’s recommendations.The patients were divided into the rejection and acceptance groups.Then we analyzed the rejected examination items in order to obtain the corresponding reasons.RESULTS:We recruited a total of 11,867 children with fever who had used Xiaoyi in outpatient clinics.The recommended examinations given by Xiaoyi for 10,636(89.6%)patients were qualified.The average F1 score reached 0.94.A total of 58.4%of the patients accepted Xiaoyi’s suggestions(acceptance group),and 41.6%refused(rejection group).Imaging examinations were rejected by most patients(46.7%).The tests being time-consuming were rejected by 2,133 patients(43.2%),including rejecting pathogen studies in 1,347 patients(68.5%)and image studies in 732 patients(31.8%).The difficulty of sampling was the main reason for rejecting routine tests(41.9%).CONCLUSION:Our model has high accuracy and acceptability in recommending medical tests to febrile pediatric patients,and is worth promoting in facilitating SDM.

Dysregulated RUNX1 Predicts Poor Prognosis by Mediating Epithelialmesenchymal Transition in Cervical Cancer

Objective Runt-related transcription factor 1(RUNX1)has been proven to be over-expressed and vital in many malignancies.However,its role in cervical cancer is still unclear.Methods Some online databases(Oncomine,GEPIA,UALCAN,LinkedOmics,and others)were used to explore the expression level,prognostic significance,and gene mutation characteristics of RUNX1 in cervical cancer.The protein levels of RUNX1 in cervical cancer were measured by immunohistochemistry(IHC).The functional changes of cervical cancer cells were measured in vitro after decreasing RUNX1.Results Bioinformatic results revealed that RUNX1 was upregulated in cervical cancer compared to normal tissues.Moreover,over-expression of RUNX1 was significantly correlated with cervical cancer patients’clinical parameters(e.g.,individual cancer stages,patients’age,nodal metastasis status,and others).Meanwhile,functional enrichment analysis of RUNX1-related genes indicated that RUNX1 was mainly involved in the epithelial-mesenchymal transition(EMT)process in cervical cancer.Furthermore,RUNX1 may be upregulated by hsamiR-616-5p and hsa-miR-766 identified by miRDB,TargetScan,and miRWalk.Finally,RUNX1 was upregulated in cervical cancer compared to normal tissues by IHC in collected cervical cancer samples.The invasion and migration abilities of cervical cancer cells were significantly reduced by repressing EMT after knocking down RUNX1 in vitro.Conclusion RUNX1 was highly expressed in cervical cancer,and upregulated RUNX1 could significantly promote the invasive abilities of cervical cancer cells by inducing EMT.Therefore,RUNX1 may be a potential biomarker for early diagnosis and targeted therapy of cervical cancer.

Isotypic heterojunction based on Fe-doped and terephthalaldehyde-modified carbon nitride for improving photocatalytic degradation with simultaneous hydrogen production

To achieve an efficient photocatalytic for clean energy production and environmental remediation,the highly active Fe-doped and terephthalaldehyde-modified carbon nitride(Fe-CN/NTE)isotypic heterojunction photocatalyst is constructed via a simple annealing method for degradation of organic pollutants with simultaneous resource recovery.The Fe-CN/NTE catalyst exhibits a 93%removal rate of pnitrophenol(4-NP)and a 1.72 mmol/g H2 evolution rate in 2 h simultaneously under visible light irradiation,which are higher than those of pristine CN,Fe-CN,and NTE,respectively.Photoelectrochemical tests show that the excellent photocatalytic performance of Fe-CN/NTE comes from the improved migration,transportation,and separation of photoinduced charge carriers and expanded light-harvesting range.Moreover,hydroxyl radical(·OH),electron(e^(-)),and hole(h^(+))are the main active species and the rational mechanism of 4-NP photodegradation was proposed based on scavenger measurements and liquid chromatography-mass spectrometry(LC–MS),respectively.Isotypic heterojunction Fe-CN/NTE photocatalyst possesses excellent stability in the H2 evolution and 4-NP degradation during five-run cycle tests,posing as a promising candidate in practical works for organic pollution and energy challenges.

Effect of tumor size on dermoscopic features of pigmented basal cell carcinoma

Basal cell carcinoma(BCC)is the most common malignant tumor of the skin and the incidence increases yearly worldwide.Most BCC is an indolent kind of tumor,it can grow into a large lesion and lost its classic performance.In addition,giant BCC has attracted the attention of researchers in recent years.111 Thus,BCC with a large tumor size also catches our attention.Dermoscopy is a useful adjuvant tool for the diagnosis and management of BCCs.[2].There are few literatures on BCC tumor size and BCC dermoscopic features.We observed and analyzed 98 cases of BCCs and found that dermoscopic features of BCCs>1 cm in diameter were different from that of smaller BCCs.

Preparation and properties of W–Cu–Zn alloy with low W–W contiguity

The W–Cu–Zn alloy with a-brass matrix and low W–W contiguity was prepared by method of electroless copper plating combined with spark plasma sintering（SPS） method.The effects of process and parameters on the microstructure and mechanical properties of the alloy were investigated.The W–Cu–Zn alloy with a relative density of 96 % and a W–W contiguity of about 10 % was prepared by original fine tungsten particles combined with wet mixing method and SPS solid-state sintering method at 800℃ for 10 min.The microstructure analysis shows that Cu–Zn matrix consists of nano-sized a-brass grains,and the main composition is Cu3Zn electride.The nano-sized Cu was coated on the surface of tungsten particles by electroless copper plating method,and the fairly low consolidation temperature and short solid-state sintering time result in the nano-sized matrix phase.The dynamic compressive strength of the W–Cu–Zn alloy achieves to1000 MPa,but the alloy shows poor ductility due to the formation of the hard and brittle Cu3Zn electrides.The fine-grain strengthening and the solution strengthening of the Cu–Zn matrix phase are responsible for the high Vickers microhardness of about 300 MPa for W–Cu–Zn alloy.