Arterial characterization of healthy descending thoracic aorta(DTA)is indispensable in determining stress distributions across wall thickness and different regions that may be responsible for aorta inhomogeneous dilat...Arterial characterization of healthy descending thoracic aorta(DTA)is indispensable in determining stress distributions across wall thickness and different regions that may be responsible for aorta inhomogeneous dilation,rupture,and dissection when aneurysm occurs.Few studies have shown the inhomogeneity of DTA along the aorta tree considering changes in circumferential direction.The present study aims to clarify the circumferential regional characterization of DTA.Porcine DTA tissues were tested according to region and orientation using uniaxial tension.For axial test,results show that the difference in circumferential direction was mainly in collagen fiber modulus,where the anterior collagen fiber modulus was significantly lower than the posterior quadrant.For circumferential test,the difference in circumferential direction was mainly in the recruitment parameter,where the circumferential stiffness is significantly higher in the posterior region at physiological maximum stress.The proximal posterior quadrant and left quadrant showed significantly lower axial collagen fiber stiffness than the right and anterior quadrants,which may be a factor in aneurysm development.Furthermore,the constitutive parameters for similar detailed regions can be used by biomedical engineers to investigate improved therapies and thoroughly understand the initial stage of aneurysm development.The regional collagen fiber modulus can help improve our understanding of the mechanisms of arterial dilation and aortic dissection.展开更多
The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussu...The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity,but the principal mechanism and molecular target of COS remain unclear.Here,we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3,altering the ATPase activity and assembly of NLRP3 inflammasome.We declare COS’s great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome activation.We also reveal that theα-methylene-γ-butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 activation.Taken together,NLRP3 is identified as a direct target of COS for its anti-inflammasome activity.COS,especially theα-methylene-γ-butyrolactone motif in COS structure,might be used to design and produce novel NLRP3 inhibitors as a lead compound.展开更多
In celebration of JIPB＇s 60th anniversary, this paper summarizes and reviews the development process of the journal. To start, we offer our heartfelt thanks to JIPB＇s pioneer Editors-in-Chief who helped get the jour...In celebration of JIPB＇s 60th anniversary, this paper summarizes and reviews the development process of the journal. To start, we offer our heartfelt thanks to JIPB＇s pioneer Editors-in-Chief who helped get the journal off the ground and make it successful. Academic achievement is the soul of academic journals, and this paper summarizes JIPB＇s course of academic development by analyzing it in four stages： the first two stages are mostly qualitative analyses, and the latter two stages are dedicated to quantitative analyses. Most-cited papers were statistically analyzed. Improvements in editing, pub- lication, distribution and online accessibility--which are detailed in this paper--contribute to JIPB＇s sustainable development. In addition, JIPB＇s evaluation index and awards are provided with accompany- ing pictures. At the end of the paper, JIPB＇s milestones are listed chronologically. We believe that JIPB＇s development, from a national journal to an international one, parallels the development of the Chinese plant sciences.展开更多
基金the support of the Nature Science Foundation of China(Grant No.11372208,11502157)Shanxi Province Programs for Science and Technology Innovation in Colleges and Universities(Grant No.2016BY062).
文摘Arterial characterization of healthy descending thoracic aorta(DTA)is indispensable in determining stress distributions across wall thickness and different regions that may be responsible for aorta inhomogeneous dilation,rupture,and dissection when aneurysm occurs.Few studies have shown the inhomogeneity of DTA along the aorta tree considering changes in circumferential direction.The present study aims to clarify the circumferential regional characterization of DTA.Porcine DTA tissues were tested according to region and orientation using uniaxial tension.For axial test,results show that the difference in circumferential direction was mainly in collagen fiber modulus,where the anterior collagen fiber modulus was significantly lower than the posterior quadrant.For circumferential test,the difference in circumferential direction was mainly in the recruitment parameter,where the circumferential stiffness is significantly higher in the posterior region at physiological maximum stress.The proximal posterior quadrant and left quadrant showed significantly lower axial collagen fiber stiffness than the right and anterior quadrants,which may be a factor in aneurysm development.Furthermore,the constitutive parameters for similar detailed regions can be used by biomedical engineers to investigate improved therapies and thoroughly understand the initial stage of aneurysm development.The regional collagen fiber modulus can help improve our understanding of the mechanisms of arterial dilation and aortic dissection.
基金supported by the National Natural Science Foundation of China(81930108 to Guang Liang,82000793 to Wu Luo,and 82170373 to Yi Wang)Natural Science Foundation of Zhejiang Province(LY22H070004 to Wu Luo,China)+1 种基金Zhejiang Provincial Key Scientific Project(2021C03041 to Guang Liang,China)Wenzhou Scientific Project in China(Y20210213 to Wu Luo)。
文摘The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity,but the principal mechanism and molecular target of COS remain unclear.Here,we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3,altering the ATPase activity and assembly of NLRP3 inflammasome.We declare COS’s great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome activation.We also reveal that theα-methylene-γ-butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 activation.Taken together,NLRP3 is identified as a direct target of COS for its anti-inflammasome activity.COS,especially theα-methylene-γ-butyrolactone motif in COS structure,might be used to design and produce novel NLRP3 inhibitors as a lead compound.
文摘In celebration of JIPB＇s 60th anniversary, this paper summarizes and reviews the development process of the journal. To start, we offer our heartfelt thanks to JIPB＇s pioneer Editors-in-Chief who helped get the journal off the ground and make it successful. Academic achievement is the soul of academic journals, and this paper summarizes JIPB＇s course of academic development by analyzing it in four stages： the first two stages are mostly qualitative analyses, and the latter two stages are dedicated to quantitative analyses. Most-cited papers were statistically analyzed. Improvements in editing, pub- lication, distribution and online accessibility--which are detailed in this paper--contribute to JIPB＇s sustainable development. In addition, JIPB＇s evaluation index and awards are provided with accompany- ing pictures. At the end of the paper, JIPB＇s milestones are listed chronologically. We believe that JIPB＇s development, from a national journal to an international one, parallels the development of the Chinese plant sciences.
