As one of the most common cancers in the world,hepatocellular carcinoma(HCC)has become a major threat to human health.Radioembolization is a first-line option for the treatment of HCC,especially when other conventiona...As one of the most common cancers in the world,hepatocellular carcinoma(HCC)has become a major threat to human health.Radioembolization is a first-line option for the treatment of HCC,especially when other conventional treatments fail or there exist some relative contraindications.Herein,we developed a facile and efficient method for preparing ^(177)Lu-microspheres potentially useful for precise radioembolization therapy of HCC.The radiolabeling efficiency of ^(177)Lu-microspheres was as high as 96.8%±0.5%,and the radiolabeling process did not alter the morphology of the mother microspheres.The SPECT/CT studies enabled by the unique emissions of ^(177)Lu suggested that almost no ^(177)Lu ion loaded by the microspheres was released over more than 32 d in vivo,which led to remarkable inhibition effect on the growth of HepG2 tumors subcutaneously transplanted in mice.The current approach may thus offer promising ^(177)Lu-microspheres for clinical radioembolization of HCC.展开更多
基金the financial support from the National Natural Science Found of China(Nos.81720108024,21976128)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the support from the Natural Science Foundation of Jiangsu Province(No.BK20200100)。
文摘As one of the most common cancers in the world,hepatocellular carcinoma(HCC)has become a major threat to human health.Radioembolization is a first-line option for the treatment of HCC,especially when other conventional treatments fail or there exist some relative contraindications.Herein,we developed a facile and efficient method for preparing ^(177)Lu-microspheres potentially useful for precise radioembolization therapy of HCC.The radiolabeling efficiency of ^(177)Lu-microspheres was as high as 96.8%±0.5%,and the radiolabeling process did not alter the morphology of the mother microspheres.The SPECT/CT studies enabled by the unique emissions of ^(177)Lu suggested that almost no ^(177)Lu ion loaded by the microspheres was released over more than 32 d in vivo,which led to remarkable inhibition effect on the growth of HepG2 tumors subcutaneously transplanted in mice.The current approach may thus offer promising ^(177)Lu-microspheres for clinical radioembolization of HCC.
