GSDME enhances Cisplatin sensitivity to regress non-small cell lung carcinoma by mediating pyroptosis to trigger antitumor immunocyte infiltration

Dear Editor,Non-small cell lung cancer(NSCLC)is the most common type of lung cancers.Since the majority of NSCLC patients are diagnosed at the advanced stage with a dramatic impact on the prognosis,chemotherapy is still the mainstay of treatment.Cisplatin(CDDP)remains one of the most widely used first-line drugs in the therapy of NSCLC,based on the clinical data that the poor outcomes of untreated NSCLC patients(5%overall survival at 1 year)have shown improvements in natural history of disease after CDDPbased chemotherapy(15%overall survival at 1 year).1 Nevertheless,Cisplatin has strong toxic side effects and many NSCLC patients treated with CDDP are easy to occur drug insensitivity,near-to-invariably leading to relapse and therapeutic failure.Therefore,finding novel target molecules which can regulate CDDP innate sensitivity is vital to improve clinical efficacy.For decades,a long-held consensus is that caspases-3-induced apoptosis is the major pattern for antitumor role of CDDP.The CDDP can promote cancer cell elimination via rewiring proproliferative signaling to pro-apoptotic pathway.However,apoptosis resistance readily occurs after CDDP treatment and it is of great significance to explore whether other types of programmed cell death can effectively heighten innate CDDP sensitivity.

Nuclear encoded elongation factor EF-Tu is required for chloroplast development in rice grown under low-temperature conditions

As a thermophilic crop that originated in tropical and subtropical areas, rice is sensitive to low temperatures, particularly during the early seedling stage. Cold stress at the seedling stage inhibits chlorophyll biosynthesis and causes oxidative damage, resulting in death(Zhao et al., 2020). Investigation of the mechanism of chloroplast development in rice seedlings under low-temperature conditions is important for breeding varieties with increased cold resistance.

Yield-height correlation and QTL localization for plant height in two lowland switchgrass populations

Switchgrass(Panicum virgatum L.), as a model herbaceous crop species for bioenergy production,is targeted to improve biomass yield and feedstock quality.Plant height is a major component contributing to biomass yield. Accordingly, the objectives of this research were to analyze phenotypic variation for biomass and plant height and the association between them and to localize associated plant height QTLs. Two lowland switchgrass mapping populations, one selfed and another hybrid population established in the field at Perkins and Stillwater,Oklahoma, were deployed in the experiment for two years post establishment. Large genetic variation existed for plant biomass and height within the two populations. Plant height was positively correlated with biomass yield in the selfed population(r = 0.39, P < 0.0001) and the hybrid population(r = 0.41, P < 0.0001). In the selfed population,a joint analysis across all environments revealed 10 QTLs and separate analysis for each environment, collectively revealed 39 QTLs related to plant height. In the hybrid population, the joint analysis across overall environments revealed 35 QTLs and the separate analysis for each environment revealed 38 QTLs. The findings of this research contribute new information about the genetic control for plant height and will be useful for future plant breeding and genetic improvement programs in lowland switchgrass.