Risk factors for post-operative delirium in elderly Chinese patients

Objective:The purpose of this study was to systematically analyze the risk factors for post-operative delirium(PD)in elderly patients in an effort to provide a basis for developing relevant clinical interventions in China.Methods:All published studies focusing on the risk factors for PD among elderly patients in Wanfant Data,China National Knowledge Infrastructure(CNKI),and VIP were collected accord-ing to the inclusion and exclusion criteria of this study.A meta-analysis was performed on case-control studies using RevMan5.2 software,and the incidence of PD risk factors was calculated among case series.Results:Sixteen studies,including 8 case-control studies and 8 case series,were included in the current study.There were 353 cases and 2008 controls in the case-control studies.The pooled odds ratios(95%CI)of PD risk factors were as follows:hypoxemia,2.58(1.59~4.18);pulmonary infection,4.51(2.23~9.13);hypertension,2.16(1.20~3.89);coronary heart disease,1.50(0.82~2.73);post-operative pain,3.18(1.63~6.20);general anesthesia,3.64(0.94~14.11);operative time,1.70(0.79~3.66);and senility,0.52(-0.25~1.29).The meta-analysis showed that hypoxemia,pulmonary infection,hypertension,coronary heart disease,post-operative pain,gen-eral anesthesia,operative time,and senility were significant risk factors for PD.There were 404 cases in the case series,and the incidence of hypoxemia,hypertension,general anesthesia,dia-betes mellitus,senility,coronary heart disease,pulmonary infection,and cerebrovascular disease was 62.62%,55.90%,33.7%,24.8%,16.58%,15.3%,13.9%,and 12.1%,respectively,which was much higher than other risk factors.Conclusion:Senility,hypertension,coronary heart disease,diabetes mellitus,pulmonary infection,hypoxemia,post-operative pain,and general anesthesia are significant risk factors for PD among elderly Chinese patients.