An asymmetric isomerization/intramolecular coupling reaction of allylic alcohols to synthesize chiral dihydrocoumarins was successfully accomplished through ruthenium catalysis.This method demonstrates a wide substrat...An asymmetric isomerization/intramolecular coupling reaction of allylic alcohols to synthesize chiral dihydrocoumarins was successfully accomplished through ruthenium catalysis.This method demonstrates a wide substrate applicability,excellent tolerance for various functional groups,and good enantioselectivities(up to 90%ee).It provides a convenient pathway to produce a diverse range ofstructurallydistinct chiral dihydrocoumarins ingoodefficiency.展开更多
基金supported by the National Natural Science Foundation of China(21801206)Shaanxi Fundamental Science Research Project for Chemistry&Biology(22JHQ002)+2 种基金the Program for Young Talents of Shaanxi Province(5113190023)the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University(CX2023104)Natural Science Basic Research Program of Shaanxi(2024JC-ZDXM-08).
文摘An asymmetric isomerization/intramolecular coupling reaction of allylic alcohols to synthesize chiral dihydrocoumarins was successfully accomplished through ruthenium catalysis.This method demonstrates a wide substrate applicability,excellent tolerance for various functional groups,and good enantioselectivities(up to 90%ee).It provides a convenient pathway to produce a diverse range ofstructurallydistinct chiral dihydrocoumarins ingoodefficiency.
