This article reviews recent developments in the non-Hermitian skin effect(NHSE),particularly on its rich interplay with topology.The review starts off with a pedagogical introduction on the modified bulk-boundary corr...This article reviews recent developments in the non-Hermitian skin effect(NHSE),particularly on its rich interplay with topology.The review starts off with a pedagogical introduction on the modified bulk-boundary correspondence,the synergy and hybridization of NHSE and band topology in higher dimensions,as well as,the associated topology on the complex energy plane such as spectral winding topology and spectral graph topology.Following which,emerging topics are introduced such as non-Hermitian criticality,dynamical NHSE phenomena,and the manifestation of NHSE beyond the traditional linear non-interacting crystal lattices,particularly its interplay with quantum many-body interactions.Finally,we survey the recent demonstrations and experimental proposals of NHSE.展开更多
Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activit...Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates(MIC:<0.002-0.030 μg/mL).Compounds 2f,5e and 5g display acceptable safety and pharmacokinetic profiles,opening a new direction for further development.展开更多
基金C.H.Lee acknowledges support from Singapore NRF’s QEP2.0 grant(NRF2021-QEP2-02-P09)MOE Tier-1 grant(WBS:A-8000022-00-00)+1 种基金L.Li acknowledges support from National Natural Science Foundation of China(Grant No.12104519)the Guangdong Project(Grant No.2021QN02X073).
文摘This article reviews recent developments in the non-Hermitian skin effect(NHSE),particularly on its rich interplay with topology.The review starts off with a pedagogical introduction on the modified bulk-boundary correspondence,the synergy and hybridization of NHSE and band topology in higher dimensions,as well as,the associated topology on the complex energy plane such as spectral winding topology and spectral graph topology.Following which,emerging topics are introduced such as non-Hermitian criticality,dynamical NHSE phenomena,and the manifestation of NHSE beyond the traditional linear non-interacting crystal lattices,particularly its interplay with quantum many-body interactions.Finally,we survey the recent demonstrations and experimental proposals of NHSE.
基金the Singapore Ministry of Education Academic Research Fund Tier-3 Grant No.MOE2017T3-1-001(WBS.No.R-144-000-425-592)the Singapore National Research Foundation Grant No.NRF-NRFI2017-04(WBS No.R-144-000-378-281)。
基金funding support by the National Natural Science Foundation of China (12104519)the Guangdong Basic and Applied Basic Research Foundation (2020A1515110773)
基金supported by the CAMS Innovation Fund for Medical Science(No.CAMS-2017-I2M-1-011)National Mega-project for Innovative Drugs(Nos.2015ZX09102007-008,2018ZX09721001004-007,2018ZX09711001-007-002)the National Natural Science Foundation of China(No.81872753)。
文摘Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates(MIC:<0.002-0.030 μg/mL).Compounds 2f,5e and 5g display acceptable safety and pharmacokinetic profiles,opening a new direction for further development.
