Revision of “Introduction to General Medicine” Based on the Six-Step Curriculum Development Process

Objective:Based on the six-step curriculum development process proposed by Professor Schneiderhan et al.,the course needs,the cognition,and course summative assessment results,combined with the career preferences and work value orientation of clinical medical students undertaking the course“Introduction to General Medicine”were surveyed.Methods:A self-designed questionnaire was used to collect information on the course cognition,course summative evaluation,and professional inclination of 233 junior medical students majoring in clinical medicine undertaking the course“Introduction to General Practice.”An analysis was conducted to provide a basis for curriculum revision in accordance with the structured composition of the curriculum development process.Results:(i)In terms of course cognition,before the course,67.0%of students were unaware of general medicine and general practitioners,73.0%of students had never participated in practical activities(including volunteer work),and 53.6%of students expressed interest in the course;there were significant differences in the growth environment,the frequency of participation in club activities,the cognition of general medicine/general practitioners before the course,participation in practical activities(including volunteer work),attentiveness to the current situation of medical treatment,and the interest toward the course(P<0.05);multi-factor logistics analysis showed that the factors influencing the interest toward the course include growth environment,frequency of participation in club activities,course cognition,participation in practical activities,and attentiveness to the current status of development of medical treatment.(ii)The course summative assessment results showed that 91.8%of students felt that it is necessary to learn this course,33.9%of students felt that the most important thing in the course is to learn the theoretical knowledge of general medicine and related diagnosis and treatment skills,53.2%of students felt that the most unfavorable factor affecting the learning of this course is the lack of interest in general medicine,and 64.4%of students hoped for more clinical practice to understand and participate in the work of general practitioners;paired t-test revealed differences in career preferences before and after the course(P<0.05);after the course,more students thought that general practitioner is an ideal career option.(iii)The results showed that 58.8%of students had considered their future specialty but did not have specific goals or plans,while 21.9%had considered their future specialty and had clear goals;there was a significant difference in professional inclination between genders as well as those who were attentive to the current state and development of medical treatment in our country and those who were not(P<0.05);with regard to the scores of importance in terms of the influencing factors of professional inclination,interest and possibility of professional development scored 3.92,ranking first,followed by income,which scored 3.91,and career prestige,which scored the lowest(3.62).Conclusion:Based on the needs assessment of clinical medical students,it is important to focus on improving students’interest in general medicine,especially their cognition and professional understanding of the course before the course itself,in addition to the development of relevant practical activities,and their attentiveness to the current state and development of medical treatment.The summative assessment results suggest that the implementation of this course has a positive influence on the career preferences of clinical medical students to a certain extent.Therefore,it is necessary to combine the course content with the development of general medicine,so as to stimulate students’interest in self-driven learning and in general medicine.This will attract more students whose work value orientation is influenced by interest and possibility of professional development to choose general practitioner as their future professional inclination.

High-precision relocation of the aftershock sequence of the January 8,2022,M_(S)6.9 Menyuan earthquake

The 2022 Menyuan M_(S)6.9 earthquake,which occurred on January 8,is the most destructive earthquake to occur near the Lenglongling(LLL)fault since the 2016 Menyuan M_(S)6.4 earthquake.We relocated the mainshock and aftershocks with phase arrival time observations for three days after the mainshock from the Qinghai Seismic Network using the double-difference method.The total length and width of the aftershock sequence are approximately 32 km and 5 km,respectively,and the aftershocks are mainly concentrated at a depth of 7-12 km.The relocated sequence can be divided into 18 km west and 13 km east segments with a boundary approximately 5 km east of the mainshock,where aftershocks are sparse.The east and west fault structures revealed by aftershock locations differ significantly.The west fault strikes EW and inclines to the south at a 71°-90°angle,whereas the east fault strikes 133°and has a smaller dip angle.Elastic strain accumulates at conjunctions of faults with different slip rates where it is prone to large earthquakes.Based on surface traces of faults,the distribution of relocated earthquake sequence and surface ruptures,the mainshock was determined to have occurred at the conjunction of the Tuolaishan(TLS)fault and LLL fault,and the west and east segments of the aftershock sequence were on the TLS fault and LLL fault,respectively.Aftershocks migrate in the early and late stages of the earthquake sequence.In the first 1.5 h after the mainshock,aftershocks expand westward from the mainshock.In the late stage,seismicity on the northeast side of the east fault is higher than that in other regions.The migration rate of the west segment of the aftershock sequence is approximately 4.5 km/decade and the afterslip may exist in the source region.

Comparison of the earthquake detection abilities of PhaseNet and EQTransformer with the Yangbi and Maduo earthquakes

PhaseNet and EQTransformer are two state-of-the-art earthquake detection methods that have been increasingly applied worldwide.To evaluate the generaliz-ation ability of the two models and provide insights for the development of new models,this study took the sequences of the Yunnan Yangbi M6.4 earthquake and Qinghai Maduo M7.4 earthquake as examples to compare the earthquake detection effects of the two abovementioned models as well as their abilities to process dense seismic sequences.It has been demonstrated from the corresponding research that due to the differences in seismic waveforms found in different geographical regions,the picking performance is reduced when the two models are applied directly to the detection of the Yangbi and Maduo earthquakes.PhaseNet has a higher recall than EQTransformer,but the recall of both models is reduced by 13%-56%when compared with the results rep-orted in the original papers.The analysis results indicate that neural networks with deeper layers and complex structures may not necessarily enhance earthquake detection perfor-mance.In designing earthquake detection models,attention should be paid to not only the balance of depth,width,and architecture but also to the quality and quantity of the training datasets.In addition,noise datasets should be incorporated during training.According to the continuous waveforms detected 21 days before the Yangbi and Maduo earthquakes,the Yangbi earthquake exhibited foreshock,while the Maduo earthquake showed no foreshock activity,indicating that the two earthquakes’nucleation processes were different.

S-wave velocity structure in the SE Tibetan plateau

We use observations recorded by 23 permanent and 99 temporary stations in the SE Tibetan plateau to obtain the S-wave velocity structure along two profiles by applying joint inversion with receiver functions and surface waves. The two profiles cross West Yunnan block(WYB),the Central Yunnan sub-block(CYB), South China block(SCB), and Nanpanjiang basin(NPB). The profile at ~25°N shows that the Moho interface in the CYB is deeper than those in the WYB and the NPB, and the topography and Moho depth have clear correspondence.Beneath the Xiaojiang fault zone(XJF), there exists a crustal low-velocity zone(LVZ), crossing the XJF and expanding eastward into the SCB. The NPB is shown to be of relatively high velocity. We speculate that the eastward extrusion of the Tibetan plateau may pass through the XJF and affect its eastern region, and is resisted by the rigid NPB, which has high velocity. This may be the main cause of the crustal thickening and uplift of the topography. In the Tengchong volcanic area, the crust is shown to have alternate high- and low-velocity layers, and the upper mantle is shown to be of low velocity. We consider that the magma which exists in the crust is from the upper mantle and that the complex crustal velocity structure is related to magmatic differentiation. Between the Tengchong volcanic area and the XJF, the crustal velocity is relatively high.Combining these observations with other geophysical evidence, it is indicated that rock strength is high and deformation is weak in this area, which is why the level of seismicity is quite low. The profile at ~23°N shows that the variation of the Moho depth is small from the eastern rigid block to the western active block with a wide range of LVZs. We consider that deformation to the south of the SE Tibetan Plateau is weak.

Nitrogen-doped lignin based carbon microspheres as anode material for high performance sodium ion batteries

Nitrogen-doped lignin-based carbon microspheres are synthesized using 3-aminophenol as a nitrogen source by the hydrothermal method.The structural change and the effect on the electrochemical properties are systematically investigated. Nitrogen-doped lignin-based carbon microspheres represent well-developed spherical morphology with many active sites, ultramicroporous(< 0.7 nm) structure, and large interlayer spacing. Consistent with the obtained physical structures and properties, the nitrogen-doped carbon microspheres exhibit fast sodium ion adsorption/intercalation kinetic process and excellent electrochemical performance. For example, a reversible specific capacity of 374 m Ah g^(-1) at 25 m A g^(-1) with high initial coulombic efficiency of 85% and high capacitance retention of 90% after 300 cycles at 100 m A g^(-1) and stable charge/discharge behavior at different current density is obtained. The additional defects and abundant ultramicroporous structure can enhance sloping capacity, and large interlayer spacing is considered to be the reason for improving plateau capacity.

Phase velocity maps of Rayleigh waves in the Ordos block and adjacent regions

We analyze continuous waveform data from 257 broadband stations of the portable seismic array deployed under the "China Seismic Array-northern part of NS seismic belt" project as well as data from a permanent seismic network from January 2014 to December 2015. The phase velocity dispersion curve of 7,185 Rayleigh waves is obtained with a method based on the image analysis of phase velocity extraction, and the inversion is obtained. The period of Rayleigh wave phase velocity distribution has a range of 5–40 s, and minimum resolution close to 20 km. The results show that the phase velocity structure image well reflects the geological structural characteristics of the crust and uppermost mantle, and that the phase velocity distribution has obvious lateral heterogeneity. The phase velocity of the 5–15 s period is closely linked to the surface layer and sedimentary layer, the low-velocity anomalies correspond to loose sedimentary cover, and the high-velocity anomalies correspond to orogenic belts and uplifts and the boundary between high and low velocity anomalies is consistent with the block boundary. The phase velocity of the 5–15 s period is strongly affected by the crust layer thickness, the northeastern Tibetan plateau has low-velocity anomalies in the middle to lower crust, the west side of the Ordos block is consistent with the northeastern Tibetan plateau, which may imply the material exchange and fusion in this area. The velocity variation is inversely related to the Moho depth in the 40 s period of Swave, and the lateral velocity heterogeneity represents the lateral variation of the Moho depth. The Ordos block and the northern margin of Sichuan basin are located in the uppermost mantle at this depth, and the depth in the transition zone is still located in the lower crust.

The Optimization and Thinking about Traditional Living Environment of the Tibetan Gongbu Culture——In the Case of Juemu Village on the Side of the Niyang River

Based on the problems of traditional living environment of the Tibetan Gongbu culture and the concept of inheriting the Tibetan Gongbu culture and the harmonious coexistence of environment and human,living environment design of Juemu Village on the side of the Niyang River is optimized. It adheres to the importance of traditional culture,and especially emphasizes the layout of buildings with Tibetan style and their surrounding,function optimization,and the plant design,thereby exploring and attempting planning method of Tibetan living environment under the background of new rural construction.

双闭环管理人工智能质量控制模式在产前超声切面质量控制中的应用价值

目的探讨双闭环管理人工智能产科超声标准切面质控模式的应用效果。方法选取华中科技大学协和深圳医院2021年第一季度和第二季度在产前超声人工智能智慧云平台上传的数据(345例共15475帧产科超声图像切面)进行人工智能质控,并在第一季度质控后针对质控结果进行学习。统计并利用χ^(2)检验对比两季度的切面标准率、基本标准率与非标准率的差异,分析两季度质控图像不标准的原因,利用申诉-专家质控的双闭环管理方式检测AI质控的准确性。结果与第一季度相比,第二季度切面标准率由80.76%提高到83.90%,非标准率由5.36%下降到3.33%,完全达到标准切面要求的切面由14.3%提高到42.9%,完全不符合要求的切面由23.8%减少到0,差异均具有统计学意义(χ^(2)=24.687、0.050、1.200、5.676,P<0.001、<0.001、=0.040、=0.017);双闭环管理方式显示人工智能质控准确率为98.5%。结论双闭环管理人工智能质控模式是一种客观、准确、高效、便捷的质控方式,该模式有利于提高产前超声检查的切面标准度,在产前超声质控工作中具有较高的应用价值。

TAOK1 negatively regulates IL-17-mediated signaling and inflammation

Interleukin 17(IL-17)is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases.However,the regulation of its signaling transduction has not been well described.In this study,we report that thousand and one kinase 1(TAOK1)functions as a negative regulator of IL-17-mediated signal transduction and inflammation.TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB.We further demonstrate that TAOK1 interacts with IL-17 receptor A(IL-17RA)independent of its kinase activity,and TAOK1 dose-dependently prevents the formation of the IL-17R-Act1(nuclear factor activator 1,also known as tumor necrosis factor receptor-associated factor 3 interacting protein 2)complex.Consistent with this,TAOK1 deficiency exacerbates colitis in the 2,4,6-trinitrobenzenesulfonic acid-induced experimental model of inflammatory bowel disease,likely by its promotion of the IL-17-mediated signaling pathway.TAOK1 expression is decreased in the colons of ulcerative colitis patients.In conclusion,these findings suggest that TAOK1 is involved in the development of IL-17-related autoimmune disorders.

Polyelectrolytes/α-Fe_(2)O_(3) modification of carbon cloth anode for dealing with food wastewater in microbial fuel cell

In this paper,the layer-by-layer assembled polydimethyl diallyl ammonium chloride(PDADMAC),poly sodium-p-styrene sulfonate(PSS)and α-Fe_(2)O_(3) modified carbon cloth(CC),nitric acid activated CC,blank CC were used as anodes in two-chamber microbial fuel cell(MFC)for dealing with food wastewater.The electricity production of microbial fuel cell increased dramatically after modification of the anode.When four double layers of PDADMAC and PSS and one layer α-Fe_(2)O_(3) was assembled on CC(CC/(PDADMAC/PSS)4/α-Fe_(2)O_(3)),the highest current 0.48 mA and the highest power density 0.285 W/m2 were obtained.The electrode process of CC/(PDADMAC/PSS)4/α-Fe_(2)O_(3) anode in MFC was controlled by the electron production step,while the blank CC anode was an electron diversion-controlled process.The high electricity production of nitric acid treated CC anode in MFC was due to the amino group after activation,which made microbes easy to anchor on the anode surface.The effect of polyelectrolytes and α-Fe_(2)O_(3) on the performance improvement of MFC was due to both physical and chemical properties of the anode surface.

Correction to: TAOK1 negatively regulates IL-17-mediated signaling and inflammation

Correction to:Cellular&Molecular Immunology(2018).https://doi.org/10.1038/cmi.2017.158;published online 5 February 2018 In this article,published online 5 February 2018,the second primer of mouse actin,il-6,il-1β,TNFα,cxcl1,cxcl2 and ccl20 in Table 2 should be marked as“reverse primer”instead of“forward primer”.Corrected Table 2 is shown below.The authors regret the errors.