Objective:To evaluate the efficacy and safety of Oxaliplatin in the patients with colorectal cancer. Methods:In a multicenter randomized control study,a total of 144 patients were divided into four groups:Oxaliplatin(...Objective:To evaluate the efficacy and safety of Oxaliplatin in the patients with colorectal cancer. Methods:In a multicenter randomized control study,a total of 144 patients were divided into four groups:Oxaliplatin(Haitong)+5-FU,CF(group A) 41 cases;5-FU+CF(group B) 41 cases;Oxaliplatin(Haitong)+5-FU,CF(group C) 31 cases;Oxaliplatin(positive drug)+5-FU+CF(group D) 31 cases. Oxaliplatin combination regimen:L-OHP 130 mg/m2 i.v. infusion 2 h d1;CF 200 mg/m2 i.v. 2 h d1-d5;5-FU 300 mg/m2 i.v. infusion 4 h d1-d5(after CF). 5-FU+CF combination regimen:CF 200 mg/m2 i.v. infusion 2 h d1-d5,5-FU 300 mg/m2 i.v. infusion 4h d1-d5(after CF),the schedule was repeated every 3 weeks. The total cycles were 3. Results:After three circles treatment,overall response rate of 4 groups was 24.4%(group A),2.4%(group B),25.8%(group C) and 19.4%(group D),respectively. The response rate was significantly different between group A and group B(P < 0.01),but no significant difference was observed between group C and group D(P > 0.05). Conclusion:The Oxaliplatin(Haitong) for injection combination regimen is effective in the treatment of colorectal cancer.展开更多
文摘Objective:To evaluate the efficacy and safety of Oxaliplatin in the patients with colorectal cancer. Methods:In a multicenter randomized control study,a total of 144 patients were divided into four groups:Oxaliplatin(Haitong)+5-FU,CF(group A) 41 cases;5-FU+CF(group B) 41 cases;Oxaliplatin(Haitong)+5-FU,CF(group C) 31 cases;Oxaliplatin(positive drug)+5-FU+CF(group D) 31 cases. Oxaliplatin combination regimen:L-OHP 130 mg/m2 i.v. infusion 2 h d1;CF 200 mg/m2 i.v. 2 h d1-d5;5-FU 300 mg/m2 i.v. infusion 4 h d1-d5(after CF). 5-FU+CF combination regimen:CF 200 mg/m2 i.v. infusion 2 h d1-d5,5-FU 300 mg/m2 i.v. infusion 4h d1-d5(after CF),the schedule was repeated every 3 weeks. The total cycles were 3. Results:After three circles treatment,overall response rate of 4 groups was 24.4%(group A),2.4%(group B),25.8%(group C) and 19.4%(group D),respectively. The response rate was significantly different between group A and group B(P < 0.01),but no significant difference was observed between group C and group D(P > 0.05). Conclusion:The Oxaliplatin(Haitong) for injection combination regimen is effective in the treatment of colorectal cancer.
