Network Curriculum Design of Traditional Chinese Medicine Pharmacy Specialty Formed by Introducing Guangxi Minority Medicine

Starting from the background and significance of the development and design of the network course of traditional Chinese medicine pharmacy specialty formed by introducing Guangxi minority medicine,this paper discusses the teaching design scheme and module construction of the network course in the development process,and summarizes the design,production and construction experience of the network course.Through practice,the teaching effect and achievement of the network course of traditional Chinese medicine pharmacy specialty formed by introducing Guangxi minority medicine are obvious.

Aureobasidium subglaciale F134 is a bifunctional whole-cell biocatalyst for Baeyer-Villiger oxidation or selective carbonyl reduction controllable by temperature

The microbial production of either ester/lactones or enantio-enriched alcohols through Baeyer-Villiger oxidation or stereoselective reduction of ketones,respectively,is possible by using whole cells of A.subglaciale F134 as a bifunctional biocatalyst.The chemoselective pattern of acetophenone biotransformation catalyzed by these cells can be regulated through reaction temperature,directing the reaction either towards oxidation or reduction products.The Baeyer–Villiger oxidation activity of A.subglaciale F134 whole cells is particularly dependent on reaction temperature.Acetophenone was transformed efficiently to phenol via the primary Baeyer–Villiger product phenyl acetate at 20℃ after 48 h with 100% conversion.In contrast,at 35℃,enantio-enriched(S)-1-phenylethanol was obtained as the sole product with 64% conversion and 89% ee.In addition,A.subglaciale F134 cells also catalyze the selective reduction of various structurally different aldehydes and ketones to alcohols with 40% to 100% yield,indicating broad substrate spectrum and good enantioselectivity in relevant cases.Our study provides a bifunctional biocatalyst systemthat can be used in Baeyer–Villiger oxidation aswell as in asymmetric carbonyl reduction,setting the stage for future work concerning the identification and isolation of the respective enzymes.

Research and Practice on Curriculum Reform of Chinese Pharmaceutical Manufacturing Major against the Backdrop of"Comprehensive Health"

Against the backdrop of Comprehensive Health,the Chinese Pharmaceutical Manufacturing major faces both opportunities and challenges.This paper describes some problems encountered in the development of the Chinese Pharmaceutical Manufacturing major,puts forward some suggestions and measures to adapt to the training of talents of Chinese pharmaceutical manufacturing against the backdrop of Comprehensive Health,and discusses the practical research on curriculum reform.

Meteorological Sensor Data Storage Mechanism Based on TimescaleDB and Kafka

The scale of meteorological sensor data increases at TB level every week. Traditional relational database is inefficient in storing and processing such data and cannot satisfy many soft requirements. However, the heterogeneity and diversity of the numerous existing NoSQL systems impede the well-informed comparison and selection of a data store appropriate for a given application context. Implementing a meteorological sensor data storage mechanism is a key challenge. Therefore, a meteorological sensor data storage mechanism based on TimescaleDB and Kafka is proposed. In this solution, meteorological sensor data was acquired and transmitted by Kafka and was sent to TimescaleDB for storage and analysis. Based on simulated meteorological sensor dataset, it compared the solution with other NoSQL stores such as Redis, MongoDB, Cassandra, HBase and Riak TS. The experimental results show that the storage mechanism proposed is superior in the storage and processing of massive meteorological sensor data.