A recent research article published in Science by Ritter et al.reported that endosomal sorting complexes required for transport(ESCRT)proteins mediate repair of lesions in the cell membrane caused by the pore-forming ...A recent research article published in Science by Ritter et al.reported that endosomal sorting complexes required for transport(ESCRT)proteins mediate repair of lesions in the cell membrane caused by the pore-forming toxin perforin at sites of cytotoxic T cell engagement.1 Subsequent entry of granzymes and initiation of apoptosis of cancer cells is thus limited,leading to reduced sensitivity against T cell‑mediated cytotoxicity.1 Along these lines,this could constitute a new critical resistance mechanism for T cellbased treatment approaches.展开更多
基金supported by the Else Kröner-Fresenius Clinician Scientist Program Cancer Immunotherapy,the Munich Clinician Scientist Program(MCSP)the DKTK School of Oncology.This work was supported by the Marie Sklodowska-Curie Program Training Network for Optimizing Adoptive T Cell Therapy of Cancer funded by the H2020 Program of the European Union(Grant 955575,to S.K.)+14 种基金the Hector Foundation(to S.K.)the International Doctoral Program i-Target:Immunotargeting of Cancer funded by the Elite Network of Bavaria(to S.K.)Melanoma Research Alliance Grants 409510(to S.K.)the Else Kröner-Fresenius-Stiftung(2021_EKFK_01,to S.K.)the German Cancer Aid(to S.K.)the Ernst-Jung-Stiftung(to S.K.)the LMU Munich’s Institutional Strategy LMUexcellent within the framework of the German Excellence Initiative(to S.K.)the Bundesministerium für Bildung und Forschung(to S.K.)the Go-Bio Initiative(to S.K.)the m4 award of the Bavarian Ministry for Economical Affairs(to S.K.)the European Research Council Grant 756017,ARMOR-T(to S.K.)the German Research Foundation(DFG)(to S.K.)the SFB-TRR 338/12021-452881907(to S.K.)the Fritz-Bender Foundation(to S.K.)the Deutsche José-Carreras Leukämie-Stiftung(to S.K.).
文摘A recent research article published in Science by Ritter et al.reported that endosomal sorting complexes required for transport(ESCRT)proteins mediate repair of lesions in the cell membrane caused by the pore-forming toxin perforin at sites of cytotoxic T cell engagement.1 Subsequent entry of granzymes and initiation of apoptosis of cancer cells is thus limited,leading to reduced sensitivity against T cell‑mediated cytotoxicity.1 Along these lines,this could constitute a new critical resistance mechanism for T cellbased treatment approaches.
