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Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes 被引量:1
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作者 Henry Liu lisa sangkum +3 位作者 Geoffrey Liu Michael Green Marilyn Li Alan Kaye 《The Journal of Biomedical Research》 CAS CSCD 2016年第5期380-385,共6页
Epinephrine is often used for the treatment of patients with heart failure, low cardiac output and cardiac arrest. It can acutely improve hemodynamic parameters; however, it does not seem to improve longer term clinic... Epinephrine is often used for the treatment of patients with heart failure, low cardiac output and cardiac arrest. It can acutely improve hemodynamic parameters; however, it does not seem to improve longer term clinical outcomes. Therefore, we hypothesized that epinephrine may induce unfavorable changes in gene expression of cardiomyocyte. Thus, we investigated effects of epinephrine exposure on the mediation or modulation of gene expression of cultured cardiomyocytes at a genome-wide scale. Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression ofangiopoietin-2 gene (~ 2.1 times), and down-regulate the gene expression of neuregulin 1 (-3.7 times), plasminogen activator inhibitor-1 (-2.4 times) and SPARC-related modular calcium-binding protein-2 (-4.5 times). These changes suggest that epinephrine exposure may induce inhibition of angiogenesis-related gene expressions in cultured rat cardiomyocytes. The precise clinical significance of these changes in gene expression, which was induced by epinephrine exposure, warrants further experimental and clinical investigations. 展开更多
关键词 EPINEPHRINE ANGIOGENESIS gene expression CARDIOMYOCYTES ANGIOPOIETIN-2 neuregulin 1 plasminogen activator inhibitor-1 SPARC-related modular calcium-binding protein
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