目的应用CiteSpace软件分析皮肤病学领域肠道菌群的研究热点与前沿。方法检索中国知网、万方、维普及Web of Science数据库中皮肤病学领域肠道菌群相关研究。应用CiteSpace 6.1.R6软件对纳入文献的发文国家、机构、学科及本领域的研究...目的应用CiteSpace软件分析皮肤病学领域肠道菌群的研究热点与前沿。方法检索中国知网、万方、维普及Web of Science数据库中皮肤病学领域肠道菌群相关研究。应用CiteSpace 6.1.R6软件对纳入文献的发文国家、机构、学科及本领域的研究热点和前沿方向进行汇总分析。结果纳入文献共529篇,其中中文文献302篇,英文文献227篇。纳入文献发文量呈逐年上升趋势。中国发文量为世界首位,但研究较为分散,机构间和研究者间缺少合作。该领域中寻常痤疮、斑秃、银屑病仍为当前研究热点;研究方向以肠道菌群组成分析、代谢产物分析及临床疗效观察为主。结论本领域文献量仍较少,但发文量处于稳定增长水平,对于炎症性皮肤病的治疗和机制探讨为本领域研究热点,机制研究以菌群构成和代谢途径探讨为主。本领域对不同皮肤病的肠道菌群核心菌群检测尚处于起步阶段,未来应进一步探索不同皮肤病的核心菌群并探究其差异以期进一步探明脑−肠−皮肤轴机制。中医药相关研究干预方式多样,已取得一定成果,但多发表于国内期刊中,相关成果尚未走向国际。展开更多
Protein phosphorylation as one of the most important post-translational modifications in mammalian cells regulates numerous biological processes. Here we propose a novel strategy for the selective isolation and sensit...Protein phosphorylation as one of the most important post-translational modifications in mammalian cells regulates numerous biological processes. Here we propose a novel strategy for the selective isolation and sensitive analysis of mul- ti-phosphopeptides based on TiO2-gratfed mesoporous materials, in which MCM-41 and SBA-15 were chosen as the hard templates. The commercialized IMAC and TiO2 nanopartices were further investigated in the phosphopeptide analysis for comparison. The enrichment efficiency was evaluated and measured by MALDI-TOF mass spectrometry. The results indicated that both TiO2-SBA-15 and TiO2-MCM-41 exhibited the preferential affinity to multi-phosphopeptides compared with the other two widely used strategies. The mesoporous TiO2 based protocol showed highly selective and sensitive properties, where phosphopepddes could be identified at femtomole.展开更多
This paper presents the design of 0.5 V multi-gigahertz cascode CMOS LNA for low power wireless communication. By splitting the direct current through conventional cascode topology, the constraint of stacking- MOS str...This paper presents the design of 0.5 V multi-gigahertz cascode CMOS LNA for low power wireless communication. By splitting the direct current through conventional cascode topology, the constraint of stacking- MOS structure for supply voltage has been removed and based on forward-body-bias technology, the circuit can operate at 0.5 V supply voltage. Design details and RF characteristics have been investigated in this paper. To verify the investigation, a 0.5 V 5.4 GHz LNA has been fabricated through 0.18 μm CMOS technology and measured. Measured results show that it obtains 9.1 dB gain, 3 dB NF with 0.5 V voltage and 2.5 mW power dissipation. The measured IIP3 is -3.5 dBm. Compared with previously published cascode LNA, it achieves the lowest supply voltage and lowest power dissipation with competitive RF performances.展开更多
文摘目的应用CiteSpace软件分析皮肤病学领域肠道菌群的研究热点与前沿。方法检索中国知网、万方、维普及Web of Science数据库中皮肤病学领域肠道菌群相关研究。应用CiteSpace 6.1.R6软件对纳入文献的发文国家、机构、学科及本领域的研究热点和前沿方向进行汇总分析。结果纳入文献共529篇,其中中文文献302篇,英文文献227篇。纳入文献发文量呈逐年上升趋势。中国发文量为世界首位,但研究较为分散,机构间和研究者间缺少合作。该领域中寻常痤疮、斑秃、银屑病仍为当前研究热点;研究方向以肠道菌群组成分析、代谢产物分析及临床疗效观察为主。结论本领域文献量仍较少,但发文量处于稳定增长水平,对于炎症性皮肤病的治疗和机制探讨为本领域研究热点,机制研究以菌群构成和代谢途径探讨为主。本领域对不同皮肤病的肠道菌群核心菌群检测尚处于起步阶段,未来应进一步探索不同皮肤病的核心菌群并探究其差异以期进一步探明脑−肠−皮肤轴机制。中医药相关研究干预方式多样,已取得一定成果,但多发表于国内期刊中,相关成果尚未走向国际。
基金supported by the National Basic Research Program of Chi-na (2007CB714506)the National Natural Science Foundation of China (20735005 & 20925517)+1 种基金Science and Technology Committee of Shanghai (10XD1406000 & 09JC1402600)Shanghai Leading Academic Disci-pline B109
文摘Protein phosphorylation as one of the most important post-translational modifications in mammalian cells regulates numerous biological processes. Here we propose a novel strategy for the selective isolation and sensitive analysis of mul- ti-phosphopeptides based on TiO2-gratfed mesoporous materials, in which MCM-41 and SBA-15 were chosen as the hard templates. The commercialized IMAC and TiO2 nanopartices were further investigated in the phosphopeptide analysis for comparison. The enrichment efficiency was evaluated and measured by MALDI-TOF mass spectrometry. The results indicated that both TiO2-SBA-15 and TiO2-MCM-41 exhibited the preferential affinity to multi-phosphopeptides compared with the other two widely used strategies. The mesoporous TiO2 based protocol showed highly selective and sensitive properties, where phosphopepddes could be identified at femtomole.
基金Project Supported by the National Science Fund for Creative Research Groups of China(No.60821062)the National Basic Research Program of China(No.2009CB320202)
文摘This paper presents the design of 0.5 V multi-gigahertz cascode CMOS LNA for low power wireless communication. By splitting the direct current through conventional cascode topology, the constraint of stacking- MOS structure for supply voltage has been removed and based on forward-body-bias technology, the circuit can operate at 0.5 V supply voltage. Design details and RF characteristics have been investigated in this paper. To verify the investigation, a 0.5 V 5.4 GHz LNA has been fabricated through 0.18 μm CMOS technology and measured. Measured results show that it obtains 9.1 dB gain, 3 dB NF with 0.5 V voltage and 2.5 mW power dissipation. The measured IIP3 is -3.5 dBm. Compared with previously published cascode LNA, it achieves the lowest supply voltage and lowest power dissipation with competitive RF performances.
