针对高动态无人机自组网中节点之间链路生存时间(Link Live Time,LLT)短和节点遭遇路由空洞次数多的问题,提出了一种基于空洞节点检测的可靠无人机自组网路由协议——GPSR-HND(Greedy Perimeter Stateless Routing Based on Hollow Node...针对高动态无人机自组网中节点之间链路生存时间(Link Live Time,LLT)短和节点遭遇路由空洞次数多的问题,提出了一种基于空洞节点检测的可靠无人机自组网路由协议——GPSR-HND(Greedy Perimeter Stateless Routing Based on Hollow Node Detection)。GPSR-HND协议中,转发节点通过空洞节点检测机制检测邻居节点状态,将有效邻居节点加入待选邻居节点集;然后基于层次分析法(Analytic Hierarchy Process,AHP)的多度量下一跳节点选择机制从待选邻居节点集中选择权重最大的邻居节点贪婪转发数据;如果待选邻居节点集为空,则从空洞邻居节点集中选择权重最大的空洞节点启动改进的周边转发机制,寻找可恢复贪婪转发模式的节点。与GPSR-NS协议和GPSR协议相比,GPSR-HND协议表现出了更好的性能,包括平均端到端时延和丢包率的改善,以及吞吐量的提高。展开更多
Lop Nur is a huge vanished lake located at the east end of Tarim Basin,northwest of China and finally dried up before 70s.In history,Lop Nur was a large lake,rich production,beautiful scenery,and there were numerous
OBJECTIVE: To observe the effect of Qibai Pingfei capsule(QBPF) medicated serum on the proliferation of rat pulmonary arterial smooth muscle cells(PASMCs) under hypoxia conditions and to investigate its key molecular ...OBJECTIVE: To observe the effect of Qibai Pingfei capsule(QBPF) medicated serum on the proliferation of rat pulmonary arterial smooth muscle cells(PASMCs) under hypoxia conditions and to investigate its key molecular effects on the Ca^(2+)/calcineurin/nuclear factor of activated T-cells 3(NFATc3) signaling pathway.METHODS: QBPF was provided to rats via continuous gavage for 10 days. Primary rat PASMCs were cultured using the direct adherent culture method.Methyl thiazolyl tetrazolium assay was used to eval-uate the effect of QBPF on PASMCs proliferation under hypoxia conditions. Laser scanning confocal microscopy was used to detect changes in intracellular free calcium([Ca^(2+)]_i) in PASMC-loaded Fluo-3-AM.Real-time quantitative polymerase chain reaction and western blot were used to detect the transcription and protein expression levels of calcineurin and NFATc3 genes in PASMCs.RESULTS: Compared with normoxia conditions,PASMCs proliferated at 12, 24, 48, and 72 h under hypoxia conditions. QBPF at concentrations of 5%,10%, and 20% could inhibit hypoxia-induced PASMC proliferation to different degrees. The inhibitory effect was most significant in the 20% QBPF group under 24 h hypoxia conditions. The concentration of [Ca^(2+)]_iin PASMCs under hypoxia was increased and [Ca^(2+)]_iwas significantly decreased when co-incubated with QBPF at 5%, 10%, and 20%. Compared with normoxia conditions, the m RNA and protein expression levels of calcineurin and NFATc3 in PASMCs induced by hypoxia were up-regulated.QBPF application significantly down-regulated m RNA and protein expression levels of calcineurin and NFATc3 in PASMCs.CONCLUSION: QBPF can effectively inhibit hypoxia-induced proliferation of PASMCs through down-regulation of key molecular expression via the Ca^(2+)/calcineurin/NFATc3 pathway.展开更多
文摘针对高动态无人机自组网中节点之间链路生存时间(Link Live Time,LLT)短和节点遭遇路由空洞次数多的问题,提出了一种基于空洞节点检测的可靠无人机自组网路由协议——GPSR-HND(Greedy Perimeter Stateless Routing Based on Hollow Node Detection)。GPSR-HND协议中,转发节点通过空洞节点检测机制检测邻居节点状态,将有效邻居节点加入待选邻居节点集;然后基于层次分析法(Analytic Hierarchy Process,AHP)的多度量下一跳节点选择机制从待选邻居节点集中选择权重最大的邻居节点贪婪转发数据;如果待选邻居节点集为空,则从空洞邻居节点集中选择权重最大的空洞节点启动改进的周边转发机制,寻找可恢复贪婪转发模式的节点。与GPSR-NS协议和GPSR协议相比,GPSR-HND协议表现出了更好的性能,包括平均端到端时延和丢包率的改善,以及吞吐量的提高。
文摘Lop Nur is a huge vanished lake located at the east end of Tarim Basin,northwest of China and finally dried up before 70s.In history,Lop Nur was a large lake,rich production,beautiful scenery,and there were numerous
基金Supported by the National Natural Science Foundation of China(Intervention Mechanism of Yiqi Huatan Quyu Recipe on Pulmonary Vascular Remodeling of Chronic Obstructive Pulmonary Disease Based on Ca~(2+)-Calcineurin-NFAT Signaling Pathway,No.81403308)the National Natural Science Foundation of China(Based on"Lung Qi Deficiency and Missing Management and Regulation"Discuss the Mechanism of Chronic Obstructive Pulmonary Disease Pulmonary Vasoconstriction and KATP Channel,No.81373598)
文摘OBJECTIVE: To observe the effect of Qibai Pingfei capsule(QBPF) medicated serum on the proliferation of rat pulmonary arterial smooth muscle cells(PASMCs) under hypoxia conditions and to investigate its key molecular effects on the Ca^(2+)/calcineurin/nuclear factor of activated T-cells 3(NFATc3) signaling pathway.METHODS: QBPF was provided to rats via continuous gavage for 10 days. Primary rat PASMCs were cultured using the direct adherent culture method.Methyl thiazolyl tetrazolium assay was used to eval-uate the effect of QBPF on PASMCs proliferation under hypoxia conditions. Laser scanning confocal microscopy was used to detect changes in intracellular free calcium([Ca^(2+)]_i) in PASMC-loaded Fluo-3-AM.Real-time quantitative polymerase chain reaction and western blot were used to detect the transcription and protein expression levels of calcineurin and NFATc3 genes in PASMCs.RESULTS: Compared with normoxia conditions,PASMCs proliferated at 12, 24, 48, and 72 h under hypoxia conditions. QBPF at concentrations of 5%,10%, and 20% could inhibit hypoxia-induced PASMC proliferation to different degrees. The inhibitory effect was most significant in the 20% QBPF group under 24 h hypoxia conditions. The concentration of [Ca^(2+)]_iin PASMCs under hypoxia was increased and [Ca^(2+)]_iwas significantly decreased when co-incubated with QBPF at 5%, 10%, and 20%. Compared with normoxia conditions, the m RNA and protein expression levels of calcineurin and NFATc3 in PASMCs induced by hypoxia were up-regulated.QBPF application significantly down-regulated m RNA and protein expression levels of calcineurin and NFATc3 in PASMCs.CONCLUSION: QBPF can effectively inhibit hypoxia-induced proliferation of PASMCs through down-regulation of key molecular expression via the Ca^(2+)/calcineurin/NFATc3 pathway.
