目的:探讨血管性认知障碍(VCI)患者中医证候分布规律及认知损害特点,为防治VCI提供理论依据。方法:采取多中心、横断面研究,选取5家三级甲等中医院,纳入符合标准362例VCI患者,应用蒙特利尔认知评估量表(montreal cognitive assessment,M...目的:探讨血管性认知障碍(VCI)患者中医证候分布规律及认知损害特点,为防治VCI提供理论依据。方法:采取多中心、横断面研究,选取5家三级甲等中医院,纳入符合标准362例VCI患者,应用蒙特利尔认知评估量表(montreal cognitive assessment,MoCA)、血管性痴呆中医辨证量表(the scale for the differentiation of syndromes of vascular dementia,SDSVD)进行评估,经过数据处理和统计学分析方法进行比较。结果:VCI患者以肾精亏虚证型最为多见,中医证型组合形式以两种证型或1种证型组合形式为主,其中虚实结合证型例数最多,占54.97%。虚证组与实证组、虚实结合证候2组在体重、BMI指数差异有统计学意义(P<0.01)。实证组在MoCA量表总分、命名因子分明显高于虚实结合证型组,差异有统计学意义(尸<0.05)。实证组在延迟回忆因子分与另外2组差异也有统计学意义(PV 0.05)。结论:VCI不同虚实证候组的认知功能损害存在差异,VCI患者中医证候以虚实夹杂为主,治疗上首当分清虚实。展开更多
Bone marrow mesenchymal stem cells(BMSCs),periosteal stem cells(PSCs),and other bone stem cells originate from embryonic bone formation,but their function and stem cell characteristics such as proliferation ability an...Bone marrow mesenchymal stem cells(BMSCs),periosteal stem cells(PSCs),and other bone stem cells originate from embryonic bone formation,but their function and stem cell characteristics such as proliferation ability and differentiation ability change at different anatomical locations.Perichondral-derived stem cells(PCSCs)are more closely related to PSCs in origin and function,usually used to be studied together with PSCs as one type of stem cell.However,this leads to the ignoration of the PCSCs'characteristics.Since the anatomical locations of these two types of stem cells diverse,PCSCs should have some differences from PSCs.In this study,the PCSCs in the perichondrium surrounding the growth plate cartilage expressed CTSK and CD200 same as PSCs.However,when compared the stem cell characteristics of PCSCs with that of PSCs,PCSCs were more elongated than PSCs in morphology and have stronger self-renewal ability,as well as stronger chondrogenic and adipogenic differentiation potentials.This study revealed the stem cell characteristics of PCSCs distinguished from PSCs,which may indicate PCSCs and PSCs should not be treated as one type of cell to research in the future.展开更多
文摘目的:探讨血管性认知障碍(VCI)患者中医证候分布规律及认知损害特点,为防治VCI提供理论依据。方法:采取多中心、横断面研究,选取5家三级甲等中医院,纳入符合标准362例VCI患者,应用蒙特利尔认知评估量表(montreal cognitive assessment,MoCA)、血管性痴呆中医辨证量表(the scale for the differentiation of syndromes of vascular dementia,SDSVD)进行评估,经过数据处理和统计学分析方法进行比较。结果:VCI患者以肾精亏虚证型最为多见,中医证型组合形式以两种证型或1种证型组合形式为主,其中虚实结合证型例数最多,占54.97%。虚证组与实证组、虚实结合证候2组在体重、BMI指数差异有统计学意义(P<0.01)。实证组在MoCA量表总分、命名因子分明显高于虚实结合证型组,差异有统计学意义(尸<0.05)。实证组在延迟回忆因子分与另外2组差异也有统计学意义(PV 0.05)。结论:VCI不同虚实证候组的认知功能损害存在差异,VCI患者中医证候以虚实夹杂为主,治疗上首当分清虚实。
基金This research was funded by the National Natural Science Foundation of China,grants number 11972068 and 12002026funded by the China Space Station Engineering Experiment Project,grants number HYZHXM01016.
文摘Bone marrow mesenchymal stem cells(BMSCs),periosteal stem cells(PSCs),and other bone stem cells originate from embryonic bone formation,but their function and stem cell characteristics such as proliferation ability and differentiation ability change at different anatomical locations.Perichondral-derived stem cells(PCSCs)are more closely related to PSCs in origin and function,usually used to be studied together with PSCs as one type of stem cell.However,this leads to the ignoration of the PCSCs'characteristics.Since the anatomical locations of these two types of stem cells diverse,PCSCs should have some differences from PSCs.In this study,the PCSCs in the perichondrium surrounding the growth plate cartilage expressed CTSK and CD200 same as PSCs.However,when compared the stem cell characteristics of PCSCs with that of PSCs,PCSCs were more elongated than PSCs in morphology and have stronger self-renewal ability,as well as stronger chondrogenic and adipogenic differentiation potentials.This study revealed the stem cell characteristics of PCSCs distinguished from PSCs,which may indicate PCSCs and PSCs should not be treated as one type of cell to research in the future.
