为了有效去除阴影噪声对遥感影像水体提取的干扰,快速准确计算大区域范围内的水面率,本文提出基于GF6(高分六号卫星)影像,利用UWI(Urban Water Index,城市水体指数)并结合FROM-GLC10(Finer Resolution Observa-tion and Monitoring of G...为了有效去除阴影噪声对遥感影像水体提取的干扰,快速准确计算大区域范围内的水面率,本文提出基于GF6(高分六号卫星)影像,利用UWI(Urban Water Index,城市水体指数)并结合FROM-GLC10(Finer Resolution Observa-tion and Monitoring of Global Land Cover 10,全球陆地覆盖精细化观测与监测10)数据,通过求交计算和小碎斑删除实现水体提取结果的精细化,有效消除了阴影等噪声对水体提取的干扰,实现水面率的快速计算。本文选择中山市作为试验区,试验区域范围广、地物背景复杂,综合对比本文算法、NDWI(Normalized Water Index,归一化水体指数)算法和TSUWI(Two-Sted Urban Water Index,城市二类水体指数)算法,从定性与定量角度分析,结果表明:本文算法提取的水体连续完整、漏提和误提较少,可有效去除阴影、建筑、道路等噪声干扰,在总体精度、Kappa系数、错分误差、漏分误差等指标均取得了较好结果。利用UWI与FROM-GLC10数据相结合计算水面率具有可行性,为工程化、大面积、快速计算水面率提供了一种新的思路。展开更多
在知识经济浪潮下,知识动态能力为企业提供了动态竞争环境下培育持续竞争优势的路径。由于知识动态能力研究具有多元化、阶段性等复杂特点,因此探究该领域知识基础与发展脉络具有重要的理论及实践意义。基于Web of Science 数据库2000-2...在知识经济浪潮下,知识动态能力为企业提供了动态竞争环境下培育持续竞争优势的路径。由于知识动态能力研究具有多元化、阶段性等复杂特点,因此探究该领域知识基础与发展脉络具有重要的理论及实践意义。基于Web of Science 数据库2000-2018年248篇知识动态能力文献,利用CiteSpace软件的可视化处理技术以及期刊双图叠加技术,分析知识动态能力研究力量分布、知识基础、研究热点、发展阶段以及学科知识流动情况,并在此基础上建立理论框架,将知识动态能力细分为重构、合成、发展、构建、复制、转换、同化和整合等能力。展开更多
目的了解海南省高血压候鸟人群的流行病学特征,为候鸟人群的健康管理提供依据。方法在海南省澄迈县红树湾社区中抽取180名在该社区居住时间3个月及以上的高血压候鸟人群作为研究对象。通过问卷与体格检查的方法收集研究对象性别、年龄...目的了解海南省高血压候鸟人群的流行病学特征,为候鸟人群的健康管理提供依据。方法在海南省澄迈县红树湾社区中抽取180名在该社区居住时间3个月及以上的高血压候鸟人群作为研究对象。通过问卷与体格检查的方法收集研究对象性别、年龄、民族、职业、服药情况、有无高血压家族史、家乡居住环境、海南居住环境(居住地周围有无水域和绿地、水域和绿地的类型)、吸烟与饮酒情况以及身高和体质量等数据,调查研究对象的流行病学特征,并采用非条件二分类Logistic回归分析影响高血压候鸟人群在海南服药前后血压降低的因素。结果共纳入180例研究对象,其中男性77例(42.8%),女性103例(57.2%),年龄≤65岁78例(43.3%);在高血压分级中,血压正常高值87例(48.3%),一级高血压56例(31.1%),二级高血压37例(20.6%)。在海南期间血压下降的候鸟中,血压分级越高的人,占比越少。年龄、高血压分级、饮食习惯、居住环境、身体质量指数(body mass index,BMI)、饮酒等与规律服用高血压药的研究对象在海南期间血压下降有关。饮食偏咸(OR=2.778,95%CI:1.070~7.213,P=0.036)、饮酒(OR=2.686,95%CI:1.042~6.925,P=0.041)是服药前舒张压降低的不利因素;超重(OR=3.487,95%CI:1.306~9.310,P=0.013)是影响服药后舒张压降低的不利因素。结论65岁以下、饮食清淡、不饮酒、BMI正常的候鸟人群血压降低较显著,环境因素、年龄、饮食习惯、生活方式等是影响血压的主要原因,可为海南高血压候鸟人群的健康管理提供参考依据。展开更多
OBJECTIVE: To investigate, in terms of Notch signaling pathway, the effect on pancreatic cancer of the extract of an anti-tumor prescription — Qingyihuaji formula(QYHJ) — from Traditional Chinese Medicine(TCM).METHO...OBJECTIVE: To investigate, in terms of Notch signaling pathway, the effect on pancreatic cancer of the extract of an anti-tumor prescription — Qingyihuaji formula(QYHJ) — from Traditional Chinese Medicine(TCM).METHODS: Nude mice were implanted subcutaneously with human pancreatic cancer cell line SW1990 and then randomly divided into four groups: Control, QYHJ extract, Gemcitabine, and Combination of QYHJ extract and gemcitabine.Treatments were given for 21 days and tumor growth was evaluated simultaneously. Then, expression of Notch receptors(Notch-1, Notch-2,Notch-3, and Notch-4) and their Jagged ligands(Jagged-1 and Jagged-2) in dissected tumor tissuewere detected by real-time quantitative reverse transcription-polymerase chain reaction and Western blot. Finally, immunohistochemistry was performed to detect CD133, a marker of pancreatic cancer stem cells(CSCs), to evaluate the impact of QYHJ extract on pancreatic CSCs.RESULTS: QYHJ extract treatment effectively inhibited the tumor growth in nude mice. The expression of both Notch-4 and Jagged-1 were decreased significantly in QYHJ treatment groups(P < 0.05), while gemcitabine alone had no significant effect in down-regulating Jagged-1(P > 0.05).No significant difference was observed in the expression of Notch-1, Notch-2, Notch-3, and Jagged-2 between three treatment groups and control group(P > 0.05). Moreover, immunohistochemical analysis showed that the number of CD133 positive cells was significantly reduced by QYHJ treatment(P < 0.05), and the combined treatment was more effective than gemcitabine alone(P < 0.05).CONCLUSION: The role of the extract in pancreatic cancer treatment was associated with down-regulation of Notch-4 and Jagged-1 in Notch signaling pathway. The extract could enhance the antitumor activity of gemcitabine and was more effective than gemcitabine in regulating Notch signaling pathway to some extent.展开更多
文摘为了有效去除阴影噪声对遥感影像水体提取的干扰,快速准确计算大区域范围内的水面率,本文提出基于GF6(高分六号卫星)影像,利用UWI(Urban Water Index,城市水体指数)并结合FROM-GLC10(Finer Resolution Observa-tion and Monitoring of Global Land Cover 10,全球陆地覆盖精细化观测与监测10)数据,通过求交计算和小碎斑删除实现水体提取结果的精细化,有效消除了阴影等噪声对水体提取的干扰,实现水面率的快速计算。本文选择中山市作为试验区,试验区域范围广、地物背景复杂,综合对比本文算法、NDWI(Normalized Water Index,归一化水体指数)算法和TSUWI(Two-Sted Urban Water Index,城市二类水体指数)算法,从定性与定量角度分析,结果表明:本文算法提取的水体连续完整、漏提和误提较少,可有效去除阴影、建筑、道路等噪声干扰,在总体精度、Kappa系数、错分误差、漏分误差等指标均取得了较好结果。利用UWI与FROM-GLC10数据相结合计算水面率具有可行性,为工程化、大面积、快速计算水面率提供了一种新的思路。
文摘在知识经济浪潮下,知识动态能力为企业提供了动态竞争环境下培育持续竞争优势的路径。由于知识动态能力研究具有多元化、阶段性等复杂特点,因此探究该领域知识基础与发展脉络具有重要的理论及实践意义。基于Web of Science 数据库2000-2018年248篇知识动态能力文献,利用CiteSpace软件的可视化处理技术以及期刊双图叠加技术,分析知识动态能力研究力量分布、知识基础、研究热点、发展阶段以及学科知识流动情况,并在此基础上建立理论框架,将知识动态能力细分为重构、合成、发展、构建、复制、转换、同化和整合等能力。
文摘目的了解海南省高血压候鸟人群的流行病学特征,为候鸟人群的健康管理提供依据。方法在海南省澄迈县红树湾社区中抽取180名在该社区居住时间3个月及以上的高血压候鸟人群作为研究对象。通过问卷与体格检查的方法收集研究对象性别、年龄、民族、职业、服药情况、有无高血压家族史、家乡居住环境、海南居住环境(居住地周围有无水域和绿地、水域和绿地的类型)、吸烟与饮酒情况以及身高和体质量等数据,调查研究对象的流行病学特征,并采用非条件二分类Logistic回归分析影响高血压候鸟人群在海南服药前后血压降低的因素。结果共纳入180例研究对象,其中男性77例(42.8%),女性103例(57.2%),年龄≤65岁78例(43.3%);在高血压分级中,血压正常高值87例(48.3%),一级高血压56例(31.1%),二级高血压37例(20.6%)。在海南期间血压下降的候鸟中,血压分级越高的人,占比越少。年龄、高血压分级、饮食习惯、居住环境、身体质量指数(body mass index,BMI)、饮酒等与规律服用高血压药的研究对象在海南期间血压下降有关。饮食偏咸(OR=2.778,95%CI:1.070~7.213,P=0.036)、饮酒(OR=2.686,95%CI:1.042~6.925,P=0.041)是服药前舒张压降低的不利因素;超重(OR=3.487,95%CI:1.306~9.310,P=0.013)是影响服药后舒张压降低的不利因素。结论65岁以下、饮食清淡、不饮酒、BMI正常的候鸟人群血压降低较显著,环境因素、年龄、饮食习惯、生活方式等是影响血压的主要原因,可为海南高血压候鸟人群的健康管理提供参考依据。
基金Supported by the National Natural Science Foundation of China(No.81173461)China Scholarship Council(No.201306100055)
文摘OBJECTIVE: To investigate, in terms of Notch signaling pathway, the effect on pancreatic cancer of the extract of an anti-tumor prescription — Qingyihuaji formula(QYHJ) — from Traditional Chinese Medicine(TCM).METHODS: Nude mice were implanted subcutaneously with human pancreatic cancer cell line SW1990 and then randomly divided into four groups: Control, QYHJ extract, Gemcitabine, and Combination of QYHJ extract and gemcitabine.Treatments were given for 21 days and tumor growth was evaluated simultaneously. Then, expression of Notch receptors(Notch-1, Notch-2,Notch-3, and Notch-4) and their Jagged ligands(Jagged-1 and Jagged-2) in dissected tumor tissuewere detected by real-time quantitative reverse transcription-polymerase chain reaction and Western blot. Finally, immunohistochemistry was performed to detect CD133, a marker of pancreatic cancer stem cells(CSCs), to evaluate the impact of QYHJ extract on pancreatic CSCs.RESULTS: QYHJ extract treatment effectively inhibited the tumor growth in nude mice. The expression of both Notch-4 and Jagged-1 were decreased significantly in QYHJ treatment groups(P < 0.05), while gemcitabine alone had no significant effect in down-regulating Jagged-1(P > 0.05).No significant difference was observed in the expression of Notch-1, Notch-2, Notch-3, and Jagged-2 between three treatment groups and control group(P > 0.05). Moreover, immunohistochemical analysis showed that the number of CD133 positive cells was significantly reduced by QYHJ treatment(P < 0.05), and the combined treatment was more effective than gemcitabine alone(P < 0.05).CONCLUSION: The role of the extract in pancreatic cancer treatment was associated with down-regulation of Notch-4 and Jagged-1 in Notch signaling pathway. The extract could enhance the antitumor activity of gemcitabine and was more effective than gemcitabine in regulating Notch signaling pathway to some extent.
