3,5-Diaryl-1,2,4-oxadiazoles were synthesized by homocoupling of chloroarylaldoxime from arylaldoxime and N-chlorosuccinimide(NCS)in the presence of Cs_(2)CO_(3) in one pot.The method is suitable for thiophene-3-carba...3,5-Diaryl-1,2,4-oxadiazoles were synthesized by homocoupling of chloroarylaldoxime from arylaldoxime and N-chlorosuccinimide(NCS)in the presence of Cs_(2)CO_(3) in one pot.The method is suitable for thiophene-3-carbaldehyde,ison-icotinaldehyde and arylaldehyde without active substituent with a yield from 19%to 78%.However,it was not suitable for aliphatic aldehydes,other heteroaromatic aldehydes and benzaldehydes carrying active groups(hydroxyl,amino and carbox-ylic acid).Compared to reported methods,this method uses only aromatic aldoxime as a single substrate.The process is sim-ple,convenient,and green,making it a reliable way to synthesize 3,5-(homo-substituted)-1,2,4-oxadiazoles.展开更多
文摘3,5-Diaryl-1,2,4-oxadiazoles were synthesized by homocoupling of chloroarylaldoxime from arylaldoxime and N-chlorosuccinimide(NCS)in the presence of Cs_(2)CO_(3) in one pot.The method is suitable for thiophene-3-carbaldehyde,ison-icotinaldehyde and arylaldehyde without active substituent with a yield from 19%to 78%.However,it was not suitable for aliphatic aldehydes,other heteroaromatic aldehydes and benzaldehydes carrying active groups(hydroxyl,amino and carbox-ylic acid).Compared to reported methods,this method uses only aromatic aldoxime as a single substrate.The process is sim-ple,convenient,and green,making it a reliable way to synthesize 3,5-(homo-substituted)-1,2,4-oxadiazoles.
