针对现有的DDoS(distributed denial of service)攻击检测模型面临大量数据时,呈现出检测效率低的问题。为适应当前网络环境,通过研究DDoS攻击检测模型、提取流量特征、计算攻击密度,提出一种基于融合稀疏注意力机制的DDoS攻击检测模型G...针对现有的DDoS(distributed denial of service)攻击检测模型面临大量数据时,呈现出检测效率低的问题。为适应当前网络环境,通过研究DDoS攻击检测模型、提取流量特征、计算攻击密度,提出一种基于融合稀疏注意力机制的DDoS攻击检测模型GVBNet(global variable block net),使用攻击密度自适应计算稀疏注意力。利用信息熵以及信息增益分析提取攻击流量的连续字节作为特征向量,通过构建基于GVBNet的网络模型在两种数据集上进行训练。实验结果表明,该方法具有良好的识别效果、检测速度以及抗干扰能力,在不同的环境下具有应用价值。展开更多
目的探讨电切镜加ELLIC冲洗器与金属空心尿管在膀胱填塞中的应用效果,以分析两种处理方式优缺点,。方法统计云南省曲靖市第一人民医院微创泌尿外科9年来处理膀胱填塞患者共87例,其中采用电切镜配合ELLIC冲洗器清除血块45例,采用金属空...目的探讨电切镜加ELLIC冲洗器与金属空心尿管在膀胱填塞中的应用效果,以分析两种处理方式优缺点,。方法统计云南省曲靖市第一人民医院微创泌尿外科9年来处理膀胱填塞患者共87例,其中采用电切镜配合ELLIC冲洗器清除血块45例,采用金属空心尿管处理患者42例。电切镜组先用电切环将膀胱血块分块切割后换用ELLIC冲洗器清除血块,检查有活动性出血患者电切镜下止血,直视下观察至膀胱内血块清除后留置一22F双腔尿管接持续膀胱冲洗;金属空心尿管处理组采用金属空心尿管接20 m L注射器反复抽吸将血块逐渐碎屑化后吸出,配合反复少量注水加抽吸有助于将血块顺利吸出,待冲洗与抽吸均顺利,膀胱区膨隆消失后留置一22F双腔尿管持续膀胱冲洗。比较两组不同处理方式的手术时间、术后冲洗时间、有效率、再次出血例数、患者投诉例数。结果 87例膀胱填塞患者均能通过两种不同方法顺利清除血块。两组患者处理后再次出血分别为4例(8.89%)、7例(16.7%)。手术有效率两组分别为100%、95.2%。两组患者手术时间分别为(53.2±6.5)min、(45.1±5.5)min,术后冲洗时间为(21.4±3.0)h、(22.7±2.8)h。手术投诉率两组分别为13.3%、2.3%。两组患者在术后再次出血、术后冲洗时间上比较差异无统计学意义,但通过金属空心尿管清除血块患者在手术时间上较经尿道电切镜处理组比较差异有统计学意义(P<0.05),患者投诉率亦明显较前者减少。结论膀胱填塞是泌尿外科常见急症。电切镜鞘配合ELLIC冲洗器及金属空心尿管均可有效清除膀胱内血块,电切镜鞘下直观、可视,并可有效处理活动性出血,但多需在硬膜外麻下进行;金属空心尿管可在床旁局麻下进行,从而可尽快解决患者痛苦,减少患者二次手术之苦,同时可有效减少医疗投诉隐患。展开更多
Objective:To study the chemical constituents in leaves of Cebera manghas.Methods:Chemical constituents were isolated by using various column chromatography and tho structures were elucidated on basis of physicochemica...Objective:To study the chemical constituents in leaves of Cebera manghas.Methods:Chemical constituents were isolated by using various column chromatography and tho structures were elucidated on basis of physicochemical constants and spectral data analysis.Results:Nine compounds were obtained including p-hydroxybenzaldehyde(1),benzamide(2),n-hexadecane acid monoglyceride(3),loliolide(4),β-sitosterol(5),cerberin(6),neriifolin(7),cerleaside A(8), daucosterol(9).Conclusions:Compounds 1-4 are obtained from this genus for the first time.展开更多
Let Hn(p)be the class of functions of the form f(z)=z p+ +∞Σ k=n akzk+p,which are analytic in the open unit disk U={z:|z|<1}.In the paper,we introduce a new subclass Bn(μ,a,c,α,p;φ)of Hn(p)and investigate its ...Let Hn(p)be the class of functions of the form f(z)=z p+ +∞Σ k=n akzk+p,which are analytic in the open unit disk U={z:|z|<1}.In the paper,we introduce a new subclass Bn(μ,a,c,α,p;φ)of Hn(p)and investigate its subordination relations,inclusion relations and distortion theorems.The results obtained include the related results of some authors as their special case.展开更多
Background Hirayama disease is a rare disease characterized by juvenile-onset of asymmetric amyotrophy, of which etiology has not been clarified. The aim of our study was to investigate the clinical and neurophysiolog...Background Hirayama disease is a rare disease characterized by juvenile-onset of asymmetric amyotrophy, of which etiology has not been clarified. The aim of our study was to investigate the clinical and neurophysiologic characteristics of Hirayama disease. Methods Neurophysiological tests, including nerve conduction studies （NCS）, F-wave and routine electromyography （EMG）, were performed in seventy-three patients with Hirayama disease. EMG was selectively performed on upper and lower extremities, sternocleidomast and thoracic paravertebral muscles according to the clinical features of the patients. Results Abnormal NCS parameters, including decreased compound muscle action potentials or delayed distal motor latency, were found in 34.2% （25/73） and 12.3% （9/73） of the patients, respectively. A total of 24.6% （18/73） of the patients showed decreased F-wave frequency. EMG demonstrated the presence of neurogenic lesions in all patients with spontaneous potentials, prolonged duration or augmentation of amplitude in motor unit potentials （MUPs）, or a single pattern of MUP recruitment. About 17.8% （13/73） of the patients showed neurogenic lesions, mostly in the C7-8 level of the cervical cord, only in the upper extremity of affected side, whereas 35.6% （26/73） of the patients possessed lesions in the upper extremities bilaterally. A total of 46.6% （34/73） of patients exhibited abnormalities in the lower extremities, sterno- cleidomast or thoracic paravertebral muscle. Changes in motor NCS were significantly correlated with muscle strength. Conclusions EMG detects diffused subclinical neurogenic lesion in a high proportion of patients with Hirayama disease. Results of our study challenge the hypothesis that Hirayama disease is a type of cervical myelopathy.展开更多
Background Amyotrophic lateral sclerosis （ALS） is a fatal neurodegenerative disorder characterized by progressive death of the upper and lower motor neurons. Transgenic mice over-expressing a mutant form of the huma...Background Amyotrophic lateral sclerosis （ALS） is a fatal neurodegenerative disorder characterized by progressive death of the upper and lower motor neurons. Transgenic mice over-expressing a mutant form of the human SOD1 gene develop an ALS-like phenotype. Currently, there is no effective treatment or drug for the fatal disease. Previous studies reported potent efficacy of dl-3-n-butylphthalide （DL-NBP） for several neurodegenerative disorders and cerebral ischemia. SOD1-G93A mice are a mouse model of ALS. In this study, we investigated the efficacy of DL-NBP on this ALS mouse model. Methods Sixty SOD1-G93A female mice were divided into four groups. The vehicle control group received 0 mg.kg-1.d-~ DL-NBP. The experimental groups received DL-NBP with doses of 30, 60 or 120 mg.kgl.d1, respectively. For measurement of motor activity, the hanging wire test and rotarod test were performed. Survival statistics were analyzed by Kaplan-Meier survival curves. The body weight of each mouse was recorded twice per week. The statistical motor unit number estimation （MUNE） technique was used to estimate the number of functioning motor units in gastrocnemius muscle. Muscle morphology was evaluated by hematoxylin and eosin staining. Motor neuron quantJtation was performed by Nissl staining and microglia activation was observed by immunohistochemistry. Results Oral administration of 60 mg.kg-l-d-1 DL-NBP significantly prolonged survival （（164.78±16.67） days） of SOD1-G93A mice compared with vehicle control （（140.00＋16.89） days）. Treating mice with DL-NBP （60 mg.kg-1.d-1） significantly decreased the progression rate of motor deficits and suppressed body weight reduction. Furthermore, we found that treating SOD1-G93A mice with DL-NBP （60 mg.kgl.d1） slowed the rate of MUNE reduction （P 〈0.01）. Motor neurons were remarkably preserved in the anterior horns in mice treated with DL-NBP （60 mg.kg-1d-1） at the stage of 19 weeks （P 〈0.01）. Treating mice with DL-NBP （60 mg.kg1.d1） significantly reduced CD11b immunoreactivity compared with vehicle control mice （P 〈0.05）. No significant effect was observed in mice treated with DL-NBP of 30 or 120 mg.kg-1.d-1. Conclusions The post-disease-onset administration of DL-NBP significantly prolonged survival and improved motor performance in SOD1-G93A mice. DL-NBP mav be a Dotential theraDeutic aaent for ALS.展开更多
文摘目的探讨电切镜加ELLIC冲洗器与金属空心尿管在膀胱填塞中的应用效果,以分析两种处理方式优缺点,。方法统计云南省曲靖市第一人民医院微创泌尿外科9年来处理膀胱填塞患者共87例,其中采用电切镜配合ELLIC冲洗器清除血块45例,采用金属空心尿管处理患者42例。电切镜组先用电切环将膀胱血块分块切割后换用ELLIC冲洗器清除血块,检查有活动性出血患者电切镜下止血,直视下观察至膀胱内血块清除后留置一22F双腔尿管接持续膀胱冲洗;金属空心尿管处理组采用金属空心尿管接20 m L注射器反复抽吸将血块逐渐碎屑化后吸出,配合反复少量注水加抽吸有助于将血块顺利吸出,待冲洗与抽吸均顺利,膀胱区膨隆消失后留置一22F双腔尿管持续膀胱冲洗。比较两组不同处理方式的手术时间、术后冲洗时间、有效率、再次出血例数、患者投诉例数。结果 87例膀胱填塞患者均能通过两种不同方法顺利清除血块。两组患者处理后再次出血分别为4例(8.89%)、7例(16.7%)。手术有效率两组分别为100%、95.2%。两组患者手术时间分别为(53.2±6.5)min、(45.1±5.5)min,术后冲洗时间为(21.4±3.0)h、(22.7±2.8)h。手术投诉率两组分别为13.3%、2.3%。两组患者在术后再次出血、术后冲洗时间上比较差异无统计学意义,但通过金属空心尿管清除血块患者在手术时间上较经尿道电切镜处理组比较差异有统计学意义(P<0.05),患者投诉率亦明显较前者减少。结论膀胱填塞是泌尿外科常见急症。电切镜鞘配合ELLIC冲洗器及金属空心尿管均可有效清除膀胱内血块,电切镜鞘下直观、可视,并可有效处理活动性出血,但多需在硬膜外麻下进行;金属空心尿管可在床旁局麻下进行,从而可尽快解决患者痛苦,减少患者二次手术之苦,同时可有效减少医疗投诉隐患。
基金supported by Hainan Provicinal Key Course Foundation of Medicinal Chemistry
文摘Objective:To study the chemical constituents in leaves of Cebera manghas.Methods:Chemical constituents were isolated by using various column chromatography and tho structures were elucidated on basis of physicochemical constants and spectral data analysis.Results:Nine compounds were obtained including p-hydroxybenzaldehyde(1),benzamide(2),n-hexadecane acid monoglyceride(3),loliolide(4),β-sitosterol(5),cerberin(6),neriifolin(7),cerleaside A(8), daucosterol(9).Conclusions:Compounds 1-4 are obtained from this genus for the first time.
基金Supported by the Doctoral Foundation of the Education Committee of China(20050574002)
文摘Let Hn(p)be the class of functions of the form f(z)=z p+ +∞Σ k=n akzk+p,which are analytic in the open unit disk U={z:|z|<1}.In the paper,we introduce a new subclass Bn(μ,a,c,α,p;φ)of Hn(p)and investigate its subordination relations,inclusion relations and distortion theorems.The results obtained include the related results of some authors as their special case.
文摘Background Hirayama disease is a rare disease characterized by juvenile-onset of asymmetric amyotrophy, of which etiology has not been clarified. The aim of our study was to investigate the clinical and neurophysiologic characteristics of Hirayama disease. Methods Neurophysiological tests, including nerve conduction studies （NCS）, F-wave and routine electromyography （EMG）, were performed in seventy-three patients with Hirayama disease. EMG was selectively performed on upper and lower extremities, sternocleidomast and thoracic paravertebral muscles according to the clinical features of the patients. Results Abnormal NCS parameters, including decreased compound muscle action potentials or delayed distal motor latency, were found in 34.2% （25/73） and 12.3% （9/73） of the patients, respectively. A total of 24.6% （18/73） of the patients showed decreased F-wave frequency. EMG demonstrated the presence of neurogenic lesions in all patients with spontaneous potentials, prolonged duration or augmentation of amplitude in motor unit potentials （MUPs）, or a single pattern of MUP recruitment. About 17.8% （13/73） of the patients showed neurogenic lesions, mostly in the C7-8 level of the cervical cord, only in the upper extremity of affected side, whereas 35.6% （26/73） of the patients possessed lesions in the upper extremities bilaterally. A total of 46.6% （34/73） of patients exhibited abnormalities in the lower extremities, sterno- cleidomast or thoracic paravertebral muscle. Changes in motor NCS were significantly correlated with muscle strength. Conclusions EMG detects diffused subclinical neurogenic lesion in a high proportion of patients with Hirayama disease. Results of our study challenge the hypothesis that Hirayama disease is a type of cervical myelopathy.
基金FENG Xin-hong and YUAN Wei contributed equally to the work. The study was supported by the grants from National Natural Science Foundation of China （No. 30971002 and No. 30911120496）.
文摘Background Amyotrophic lateral sclerosis （ALS） is a fatal neurodegenerative disorder characterized by progressive death of the upper and lower motor neurons. Transgenic mice over-expressing a mutant form of the human SOD1 gene develop an ALS-like phenotype. Currently, there is no effective treatment or drug for the fatal disease. Previous studies reported potent efficacy of dl-3-n-butylphthalide （DL-NBP） for several neurodegenerative disorders and cerebral ischemia. SOD1-G93A mice are a mouse model of ALS. In this study, we investigated the efficacy of DL-NBP on this ALS mouse model. Methods Sixty SOD1-G93A female mice were divided into four groups. The vehicle control group received 0 mg.kg-1.d-~ DL-NBP. The experimental groups received DL-NBP with doses of 30, 60 or 120 mg.kgl.d1, respectively. For measurement of motor activity, the hanging wire test and rotarod test were performed. Survival statistics were analyzed by Kaplan-Meier survival curves. The body weight of each mouse was recorded twice per week. The statistical motor unit number estimation （MUNE） technique was used to estimate the number of functioning motor units in gastrocnemius muscle. Muscle morphology was evaluated by hematoxylin and eosin staining. Motor neuron quantJtation was performed by Nissl staining and microglia activation was observed by immunohistochemistry. Results Oral administration of 60 mg.kg-l-d-1 DL-NBP significantly prolonged survival （（164.78±16.67） days） of SOD1-G93A mice compared with vehicle control （（140.00＋16.89） days）. Treating mice with DL-NBP （60 mg.kg-1.d-1） significantly decreased the progression rate of motor deficits and suppressed body weight reduction. Furthermore, we found that treating SOD1-G93A mice with DL-NBP （60 mg.kgl.d1） slowed the rate of MUNE reduction （P 〈0.01）. Motor neurons were remarkably preserved in the anterior horns in mice treated with DL-NBP （60 mg.kg-1d-1） at the stage of 19 weeks （P 〈0.01）. Treating mice with DL-NBP （60 mg.kg1.d1） significantly reduced CD11b immunoreactivity compared with vehicle control mice （P 〈0.05）. No significant effect was observed in mice treated with DL-NBP of 30 or 120 mg.kg-1.d-1. Conclusions The post-disease-onset administration of DL-NBP significantly prolonged survival and improved motor performance in SOD1-G93A mice. DL-NBP mav be a Dotential theraDeutic aaent for ALS.
