Cardiogenic shock(CS)is a common cause of mortality and treatment remains challenging despite advances in therapeutic options.CS is caused by severe impairment of myocardial performance that results in decreased cardi...Cardiogenic shock(CS)is a common cause of mortality and treatment remains challenging despite advances in therapeutic options.CS is caused by severe impairment of myocardial performance that results in decreased cardiac output,hypoperfusion of the end organ,and hypoxia.Clinically this presents as hypotension refractory to volume resuscitation with features of end-organ hypoperfusion requiring pharmacological or mechanical intervention.Acute myocardial infarction(AMI)accounts for 81%of patients with CS.Heat shock protein family B member 1(HSPB1)is a multifunctional protein induced by various stress factors and has a protective effect on cells.A large number of studies have demonstrated that HSPB1 plays an important role in regulating apoptosis.Recently,some studies have suggested that HSPB1 also participates in the autophagic process.HSPB1 are expressed in many cells of the cardiovascular system such as endothelial cells,cardiac muscle cells,monocytes,and platelets.They are up-regulated in response to inflammation,oxidative stress,or ischemia and protect cells against extracellular stress factors.Here,we explore the involvement of HSPB1 in apoptosis,autophagy,and CS.We speculate that HSPB1 may exert its anti-myocardial injury role via the regulation of apoptosis and autophagy;this may provide the basis for the development of new approaches for the prevention and treatment of CS.展开更多
Lymphopenia has been implicated in patients infected with Severe Acute Respiratory Syndrome Coronavirus-2,while the association of Lymphocyte count and changes with subsequent the progression of COVID-19 remains uncle...Lymphopenia has been implicated in patients infected with Severe Acute Respiratory Syndrome Coronavirus-2,while the association of Lymphocyte count and changes with subsequent the progression of COVID-19 remains unclear.The clinical and laboratory data of 228 patients with the definite outcome by February 19,2020 in the First Hospital of Changsha were reviewed.The characteristics of COVID-19 with lymphopenia patients in age distribution,underlying diseases,hospitalization,treatment and hospitalization time were analyzed.Meanwhile,we analyzed the difference between the change of lymphocyte count and the progress of the disease within15 days.Among the 228 patients,226(99.1%)were discharged and survived,and 2(0.8%)were died.The hospitalization days(≥15)of patients with lymphopenia(77.2%)of almost three times as high as that for nonlymphopenia(23.6%)(P<0.05).Compared with the non-lymphopenia,COVID-19 with lymphopenia had a higher proportion of severe patients(32.4%vs.67.6%)(P<0.05).Dynamic changes of lymphocyte were also closely related to the progress of COVID-19 during hospitalization.Baseline lymphocyte levels and changes were associated with subsequent progression.Monitoring lymphocyte during hospitalization may be important in the prognosis of COVID-19.展开更多
文摘Cardiogenic shock(CS)is a common cause of mortality and treatment remains challenging despite advances in therapeutic options.CS is caused by severe impairment of myocardial performance that results in decreased cardiac output,hypoperfusion of the end organ,and hypoxia.Clinically this presents as hypotension refractory to volume resuscitation with features of end-organ hypoperfusion requiring pharmacological or mechanical intervention.Acute myocardial infarction(AMI)accounts for 81%of patients with CS.Heat shock protein family B member 1(HSPB1)is a multifunctional protein induced by various stress factors and has a protective effect on cells.A large number of studies have demonstrated that HSPB1 plays an important role in regulating apoptosis.Recently,some studies have suggested that HSPB1 also participates in the autophagic process.HSPB1 are expressed in many cells of the cardiovascular system such as endothelial cells,cardiac muscle cells,monocytes,and platelets.They are up-regulated in response to inflammation,oxidative stress,or ischemia and protect cells against extracellular stress factors.Here,we explore the involvement of HSPB1 in apoptosis,autophagy,and CS.We speculate that HSPB1 may exert its anti-myocardial injury role via the regulation of apoptosis and autophagy;this may provide the basis for the development of new approaches for the prevention and treatment of CS.
基金China Hunan provincial science&technology department foundation(Grant No.2020SK3011)COVID-19 special program of Changsha science and technology(Grant No.kq2001020)。
文摘Lymphopenia has been implicated in patients infected with Severe Acute Respiratory Syndrome Coronavirus-2,while the association of Lymphocyte count and changes with subsequent the progression of COVID-19 remains unclear.The clinical and laboratory data of 228 patients with the definite outcome by February 19,2020 in the First Hospital of Changsha were reviewed.The characteristics of COVID-19 with lymphopenia patients in age distribution,underlying diseases,hospitalization,treatment and hospitalization time were analyzed.Meanwhile,we analyzed the difference between the change of lymphocyte count and the progress of the disease within15 days.Among the 228 patients,226(99.1%)were discharged and survived,and 2(0.8%)were died.The hospitalization days(≥15)of patients with lymphopenia(77.2%)of almost three times as high as that for nonlymphopenia(23.6%)(P<0.05).Compared with the non-lymphopenia,COVID-19 with lymphopenia had a higher proportion of severe patients(32.4%vs.67.6%)(P<0.05).Dynamic changes of lymphocyte were also closely related to the progress of COVID-19 during hospitalization.Baseline lymphocyte levels and changes were associated with subsequent progression.Monitoring lymphocyte during hospitalization may be important in the prognosis of COVID-19.
