INCREASING evidence has demonstrated that the locally controlled proteolytic activity generatedby coordinated expression of tPA and PAI-1 in different tissues may play an important role inmany reproductive events. The...INCREASING evidence has demonstrated that the locally controlled proteolytic activity generatedby coordinated expression of tPA and PAI-1 in different tissues may play an important role inmany reproductive events. These are largely related to fibrinolytic activity. They include folli-cle rupture, luteolysis, spermatogenesis and trophoblast implantation. Parturition, whichis a complex process, may also be associated with tissue destruction. Detachment of placentaldecidua and partial breakdown of fetal membranes are possible examples. It has been展开更多
EPIDIDYMIS is the site where spermatozoa released from testis undergo maturation and become capable of fertilizing ova.The epididymal secretions including enzymes,nutrients and hor-mones are believed to be essential f...EPIDIDYMIS is the site where spermatozoa released from testis undergo maturation and become capable of fertilizing ova.The epididymal secretions including enzymes,nutrients and hor-mones are believed to be essential for sperm maturation.Limited proteolysis contributes toloss or modification of surface molecules of spermatozoa,which is an important aspect of展开更多
THE 8-chloroadenosine (8CA) is a novel analog of adenosine synthesized in the National Research Laboratories of Natural and Biomimetic Drugs. Fang et al. reported that 8CA is capable of inhibiting the cell growth in v...THE 8-chloroadenosine (8CA) is a novel analog of adenosine synthesized in the National Research Laboratories of Natural and Biomimetic Drugs. Fang et al. reported that 8CA is capable of inhibiting the cell growth in vitro of mouse liver cancer cells and human展开更多
This minireview summarized our recent studies on the role of plasminogen activator (PA) and inhibitor type-1 (PAI-1) in luteolysis. We have demonstrated that (1) both tissue type and urokinase type plasminogen activat...This minireview summarized our recent studies on the role of plasminogen activator (PA) and inhibitor type-1 (PAI-1) in luteolysis. We have demonstrated that (1) both tissue type and urokinase type plasminogen activators (tPA and uPA) and a plasminogen activator inhibitor type-1 (PAI-1) were present in the corpus luteum of rat and rhesus monkey; (2) decrease in progesterone production in corpus luteum was well correlated with a sharp increase in tPA (but not uPA) and PAI-1 secretion; (3) exogenous tPA decreased luteal progesterone synthesis while monoclonal antibodies increased progesterone production; (4) interferon y inhibited luteal progesterone synthesis and stimulated tPA production while LH plus pro-lactin increased progesterone production and decreased tPA (but not uPA) activity in cultured luteal cells; (5) increase in proteolysis in the corpus luteum was also correlated with decrease in progesterone production in mouse. These data suggest that local degradation of extracellular matrix展开更多
THE physiological function of tPA and PAI-1 in rat and monkey ovulation has been previously documented. In order to elucidate the function of tPA and PAI-1 in spermatogenesis, we have studied expression of tPA and PAI...THE physiological function of tPA and PAI-1 in rat and monkey ovulation has been previously documented. In order to elucidate the function of tPA and PAI-1 in spermatogenesis, we have studied expression of tPA and PAI-1mRNA in rat testis by in situ hybridization,展开更多
文摘INCREASING evidence has demonstrated that the locally controlled proteolytic activity generatedby coordinated expression of tPA and PAI-1 in different tissues may play an important role inmany reproductive events. These are largely related to fibrinolytic activity. They include folli-cle rupture, luteolysis, spermatogenesis and trophoblast implantation. Parturition, whichis a complex process, may also be associated with tissue destruction. Detachment of placentaldecidua and partial breakdown of fetal membranes are possible examples. It has been
文摘EPIDIDYMIS is the site where spermatozoa released from testis undergo maturation and become capable of fertilizing ova.The epididymal secretions including enzymes,nutrients and hor-mones are believed to be essential for sperm maturation.Limited proteolysis contributes toloss or modification of surface molecules of spermatozoa,which is an important aspect of
文摘THE 8-chloroadenosine (8CA) is a novel analog of adenosine synthesized in the National Research Laboratories of Natural and Biomimetic Drugs. Fang et al. reported that 8CA is capable of inhibiting the cell growth in vitro of mouse liver cancer cells and human
文摘This minireview summarized our recent studies on the role of plasminogen activator (PA) and inhibitor type-1 (PAI-1) in luteolysis. We have demonstrated that (1) both tissue type and urokinase type plasminogen activators (tPA and uPA) and a plasminogen activator inhibitor type-1 (PAI-1) were present in the corpus luteum of rat and rhesus monkey; (2) decrease in progesterone production in corpus luteum was well correlated with a sharp increase in tPA (but not uPA) and PAI-1 secretion; (3) exogenous tPA decreased luteal progesterone synthesis while monoclonal antibodies increased progesterone production; (4) interferon y inhibited luteal progesterone synthesis and stimulated tPA production while LH plus pro-lactin increased progesterone production and decreased tPA (but not uPA) activity in cultured luteal cells; (5) increase in proteolysis in the corpus luteum was also correlated with decrease in progesterone production in mouse. These data suggest that local degradation of extracellular matrix
文摘THE physiological function of tPA and PAI-1 in rat and monkey ovulation has been previously documented. In order to elucidate the function of tPA and PAI-1 in spermatogenesis, we have studied expression of tPA and PAI-1mRNA in rat testis by in situ hybridization,
